gba3
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  • Official Full Name
  • glucosidase, beta, acid 3 (cytosolic)
  • Background
  • GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes;beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be;involved in detoxification of plant glycosides (de Graaf et al., 2001 (PubMed 11389701)). GBA3 also has significant;neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic;pathway of glucosylceramide metabolism (Hayashi et al., 2007 (PubMed 17595169)).
  • Synonyms
  • GBA3; glucosidase, beta, acid 3 (cytosolic); cytosolic beta-glucosidase; GLUC; klotho related protein; KLrP; CBG; CBGL1; Cytosolic beta glucosidase; Cytosolic beta glucosidase like protein 1; Cytosolic beta-glucosidase-like protein 1; GBA3_HUMAN; Glucosidase beta acid 3; klotho-related protein
Cat.#:GBA3-1327HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA3 Protein, MYC/DDK-tagged
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Cat.#:GBA3-4768HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GBA3 Protein, GST-tagged
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Cat.#:GBA3-13175HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GBA3, His-tagged
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Cat.#:GBA3-174HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GBA3 protein, His-tagged
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Cat.#:GBA3-626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human glucosidase, beta, acid 3, His-tagged
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Cat.#:GBA3-856HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GBA3, His tagged
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Cat.#:GBA3-2855ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GBA3
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Cat.#:GBA3-661HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GBA3 cell lysate
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Involved Pathway

GBA3 involved in several pathways and played different roles in them. We selected most pathways GBA3 participated on our site, such as Cyanoamino acid metabolism, Starch and sucrose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cyanoamino acid metabolism
GGT6; GGT5A; GBA3; GGT1A; GGT5; SHMT2; GGT7; SHMT1; GGT1
Starch and sucrose metabolism
UGP2B; UGT1A2; UGT1A6A; G6PCA.1; GYS2; PYGB; UGT2A3; HK2; ENPP3; HKDC1
Metabolic pathways
CNDP1; EXT1; EXT1B; B3GNT3; PIGH; AMY2A3; NDUFV3; SUCLA2; CNDP2; LASS5

Protein Function

GBA3 has several biochemical functions, for example, beta-galactosidase activity, beta-glucosidase activity, glycosylceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GBA3 itself. We selected most functions GBA3 had, and list some proteins which have the same functions with GBA3. You can find most of the proteins on our site.
Function
Related Protein
Function beta-galactosidase activity
Related Protein GLB1; GBA3; GLB1L3; GLB1L2; GLB1L
Function beta-glucosidase activity
Related Protein GBA3; GBA2
Function glycosylceramidase activity
Related Protein GBA3

Interacting Protein

GBA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBA3.
PRKCSH

GBA3 Related Articles

Wang, SY; Fu, LL; et al. In silico analysis and experimental validation of active compounds from fructus Schisandrae chinensis in protection from hepatic injury. CELL PROLIFERATION 48:86-94(2015).
Kallemeijn, WW; Witte, MD; et al. A Sensitive Gel-based Method Combining Distinct Cyclophellitol-based Probes for the Identification of Acid/Base Residues in Human Retaining beta-Glucosidases. JOURNAL OF BIOLOGICAL CHEMISTRY 289:35351-35362(2014).