gchfr
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  • Official Full Name
  • GTP cyclohydrolase I feedback regulator
  • Background
  • GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
  • Synonyms
  • GCHFR; GTP cyclohydrolase I feedback regulator; GTP cyclohydrolase I feedback regulatory protein; GTP cyclohydrolase 1 feedback regulatory protein; GFRP; HsT16933; GFRP_HUMAN; MGC138467; MGC138469; p35; OTTHUMP00000160546
Cat.#:GCHFR-4796HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GCHFR Protein, GST-tagged
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Cat.#:GCHFR-245HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GCHFR, His-tagged
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Cat.#:GCHFR-6264MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GCHFR Protein
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Cat.#:GCHFR-2490RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GCHFR Protein
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Cat.#:GCHFR-1821RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GCHFR Protein, His-tagged
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Cat.#:GCHFR-4361CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GCHFR
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Cat.#:GCHFR-11025ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GCHFR
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Cat.#:GCHFR-692HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GCHFR cell lysate
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Involved Pathway

GCHFR involved in several pathways and played different roles in them. We selected most pathways GCHFR participated on our site, such as Metabolism, Metabolism of nitric oxide, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCHFR were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism
SUMF2; VAPB; INSIG1; CRYM; CIAPIN1; APOF; PPM1L; PDP1; NDUFAF3; SLC25A32
Metabolism of nitric oxide
DDAH2; NOSTRIN; NOSIP; LYPLA1; GCHFR; CYGB2; CYGB1; ZDHHC21; CYGB; SPRB
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
GCHFR; SPRB
eNOS activation and regulation
CYGB; SPRB; LYPLA1; DDAH1; NOSTRIN; ZDHHC21; NOSIP; CYGB1; GCHFR; CYGB2

Protein Function

GCHFR has several biochemical functions, for example, GTP cyclohydrolase binding, GTP-dependent protein binding, amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCHFR itself. We selected most functions GCHFR had, and list some proteins which have the same functions with GCHFR. You can find most of the proteins on our site.
Function
Related Protein
Function GTP cyclohydrolase binding
Related Protein GCHFR
Function GTP-dependent protein binding
Related Protein CDC42; PPIAL4A; RAPGEF5; RAPGEF6; GCH1; MRAS; RAB5B; ARFIP2; EEA1; AP1G1
Function amino acid binding
Related Protein TAT; AGXT; AARS2; GOT2; DDAH1; TH; TPH2; TPH1; TPH1A; DDAH2
Function enzyme inhibitor activity
Related Protein OAZ2A; CALU; ANGPTL4; FRY; PRPSAP1; CD46; PPP1R12A; PDE6G; APOV1; CSN2
Function protein binding
Related Protein HCST; GRIN3A; BRCC3; KLF6; NR2F1; MYH7B; C1orf105; INHBA; ARF6; PPP2R5E

Interacting Protein

GCHFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCHFR here. Most of them are supplied by our site. Hope this information will be useful for your research of GCHFR.
GCH1