gcnt1
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  • Official Full Name
  • glucosaminyl (N-acetyl) transferase 1, core 2
  • Background
  • This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms
  • GCNT1; glucosaminyl (N-acetyl) transferase 1, core 2; glucosaminyl (N acetyl) transferase 1, core 2 (beta 1,6 N acetylglucosaminyltransferase) , NACGT2; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; beta 1; 3 galact
Cat.#:GCNT1-4804HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GCNT1 Protein, GST-tagged
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Cat.#:GCNT1-617HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human Glucosaminyl (N-acetyl) Transferase 1, Core 2, His-tagged
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Cat.#:GCNT1-13198HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GCNT1, GST-tagged
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Cat.#:GCNT1-27452THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GCNT1
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Cat.#:GCNT1-714HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human GCNT1, His-tagged
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Cat.#:GCNT1-5980HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GCNT1 293 Cell Lysate
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Involved Pathway

GCNT1 involved in several pathways and played different roles in them. We selected most pathways GCNT1 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mucin type O-Glycan biosynthesis
GCNT1; ST3GAL2; GCNT4A; GALNTL2; GALNTL6; ST6GALNAC1; GALNTL4; GALNT1; B4GALT5; GALNT6
Metabolic pathways
MGAT4A; ST3GAL5; B3GALT5; PLA2G2E; DPYD; ALDH1A1; DCT; LPCAT1; MBOAT2; NDUFC1

Protein Function

GCNT1 has several biochemical functions, for example, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT1 itself. We selected most functions GCNT1 had, and list some proteins which have the same functions with GCNT1. You can find most of the proteins on our site.
Function
Related Protein
Function beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
Related Protein GCNT4; GCNT4A; GCNT1; GCNT3
Function protein binding
Related Protein CNOT7; PLXNB2; ALKBH6; RAB5B; C1GALT1C1; HHIPL2; BBS4; ALPI; UBQLN4; CITED1

Interacting Protein

GCNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCNT1.
GOLPH3; SEC24D; LAP3; CLTC; HSPA14; RSU1; CCDC80; VPS36; STMN2; CCT7; OSBPL1A; PARVA

GCNT1 Related Articles

Petrosyan, A; Holzapfel, MS; et al. Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-Induced Apoptosis by Modifying Mucin O-Glycan Synthesis. MOLECULAR CANCER RESEARCH 12:1704-1716(2014).
Chen, ZX; Gulzar, ZG; et al. Increased Expression of GCNT1 is Associated With Altered O-glycosylation of PSA, PAP, and MUC1 in Human Prostate Cancers. PROSTATE 74:1059-1067(2014).