gfra2
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  • Official Full Name
  • GDNF family receptor alpha 2
  • Background
  • Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • GFRA2; GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNFRB; NTNRA; RETL2; TRNR2; GDNFR-beta; NTNR-alpha; GFR-alpha 2; RET ligand 2; GDNFR-alpha-2; GDNF receptor beta; neurturin receptor alpha; TRN receptor, GPI-anchored; PI-linked cell-surf
Cat.#:GFRA2-359HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GFRA2 Protein, His-tagged
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Cat.#:GFRA2-713HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GFRA2 Protein, His-tagged
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Cat.#:Gfra2-360MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gfra2 Protein, His-tagged
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Cat.#:GFRA2-1619HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human GDNF Family Receptor Alpha 2
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Cat.#:GFRA2-3162HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GFRA2, His tagged
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Cat.#:GFRA2-893HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human GFRA2 Protein, Fc Chimera
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Cat.#:Gfra2-1742MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Gfra2
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Cat.#:Gfra2-3278MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Gfra2, His tagged
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Cat.#:GFRA2-6658CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GFRA2
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Cat.#:GFRA2-2425HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human GFRA2 cell lysate
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Cat.#:GFRA2-2408MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse GFRA2 cell lysate
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Involved Pathway

GFRA2 involved in several pathways and played different roles in them. We selected most pathways GFRA2 participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
EFNB2A; FRS2B; NTN1; EPHA3; ABLIM3; RND1L; PAK3; EPHA7; DNM2; LIMK1
Developmental Biology
FRS3; FRS2B; PAQR3A; EFNA5; MED16; CHL1; DPYSL5A; MYL12B; CDON; MED21
NCAM signaling for neurite out-growth
GFRA4; PSPN; COL9A1B; GFRA2; GDNF; NRTN; COL9A1A; ST8SIA2; GFRA1
NCAM1 interactions
COL9A1A; GFRA4; GFRA2; NRTN; PSPN; COL9A1B; GFRA1; GDNF

Protein Function

GFRA2 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA2 itself. We selected most functions GFRA2 had, and list some proteins which have the same functions with GFRA2. You can find most of the proteins on our site.
Function
Related Protein
Function glial cell-derived neurotrophic factor receptor activity
Related Protein GFRA1; GFRA2; GFRA4

GFRA2 Related Gene Family

TGF