ggct
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  • Official Full Name
  • gamma-glutamylcyclotransferase
  • Background
  • The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms
  • GGCT; gamma-glutamylcyclotransferase; C7orf24, chromosome 7 open reading frame 24 , GCTG; CRF21; Ggc; MGC3077; cytochrome c-releasing factor 21; gamma -glutamyl cyclotransferase; GCTG; C7orf24; FLJ11717
Cat.#:GGCT-4869HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GGCT Protein, GST-tagged
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Cat.#:GGCT-1030HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GGCT
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Cat.#:GGCT-13239HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GGCT, His-tagged
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Cat.#:GGCT-28745THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GGCT, His-tagged
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Cat.#:GGCT-307HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GGCT Protein, His-tagged
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Cat.#:GGCT-538HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GGCT, His tagged
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Cat.#:GGCT-956HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GGCT, His-tagged
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Cat.#:GGCT-1837RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GGCT Protein, His-tagged
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Involved Pathway

GGCT involved in several pathways and played different roles in them. We selected most pathways GGCT participated on our site, such as Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGCT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
GGT1; GSTM1; GSTT1B; MGST1; GSTA5; G6PDX; RRM2; SMS; GPX6; GSTA4

Protein Function

GGCT has several biochemical functions, for example, gamma-glutamylcyclotransferase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGCT itself. We selected most functions GGCT had, and list some proteins which have the same functions with GGCT. You can find most of the proteins on our site.
Function
Related Protein
Function gamma-glutamylcyclotransferase activity
Related Protein GGCTA; GGACT.1; GGACT.3; GGACT.2; GGCT; GGCTB; GGACT
Function protein homodimerization activity
Related Protein TYR; ADRA2C; EEA1; GPD1A; GDF6; ADSSL1; SLC14A2; GSTM2; NETO2; ATIC

Interacting Protein

GGCT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGCT here. Most of them are supplied by our site. Hope this information will be useful for your research of GGCT.
RASSF10; RASSF9; EGFR; RASSF7; STK4; TSNAX

GGCT Related Articles

Ran, R; Liu, YY; et al. PEGylated Hyaluronic Acid-Modified Liposomal Delivery System with Anti-gamma-Glutamylcyclotransferase siRNA for Drug-Resistant MCF-7 Breast Cancer Therapy. JOURNAL OF PHARMACEUTICAL SCIENCES 104:476-484(2015).
Yoshiya, T; Ii, H; et al. A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells. ORGANIC & BIOMOLECULAR CHEMISTRY 13:3182-3185(2015).