Recombinant Human GGCT Protein, His-tagged

• Cat.No.: GGCT-307H
• Product Overview: Recombinant Human GGCT(Met1-Leu188) fused with His tag at C-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by tHis gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of tHis gene is a potential marker for cancer. Pseudogenes of tHis gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for tHis gene.
• Source: E. coli
• Tag: His
• Form: 20mM Tris-HCl, pH 8.0. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 23.2 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GGCT gamma-glutamylcyclotransferase [ Homo sapiens ]
• Official Symbol: GGCT
• Synonyms: GGCT; gamma-glutamylcyclotransferase; C7orf24, chromosome 7 open reading frame 24 , GCTG; CRF21; Ggc; MGC3077; cytochrome c-releasing factor 21; gamma -glutamyl cyclotransferase; GGC; GCTG; C7orf24; FLJ11717
• Gene ID: 79017
• mRNA Refseq: NM_001199815
• Protein Refseq: NP_001186744
• MIM: 137170
• UniProt ID: O75223