glb1
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  • Official Full Name
  • galactosidase, beta 1
  • Background
  • This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • GLB1; galactosidase, beta 1; elastin receptor 1 (67kD) , elastin receptor 1, 67kDa , ELNR1; beta-galactosidase; EBP; Acid beta galactosidase; Acid beta-galactosidase; Beta galactosidase; BGAL_HUMAN; Elastin receptor 1 (67kD); Elastin receptor 1 67kDa; Elastin receptor 1; ELNR1; Galactosidase beta 1; GLB 1; Lactase; OTTHUMP00000208610; OTTHUMP00000208611; OTTHUMP00000208612; elastin receptor 1, 67kDa; MPS4B
Cat.#:GLB1-4945HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GLB1 Protein, GST-tagged
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Cat.#:GLB1-13292HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLB1, His-tagged
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Cat.#:GLB1-174HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GLB1 protein, His-tagged
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Cat.#:GLB1-180HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLB1 Protein, His-tagged
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Cat.#:GLB1-7758HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GLB1 protein, His-tagged
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Cat.#:GLB1-7790HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GLB1, His-tagged
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Cat.#:Glb1-181MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Glb1 Protein, His-tagged
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Cat.#:GLB1-6392MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GLB1 Protein
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Cat.#:Glb1-182RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Glb1 Protein, His-tagged
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Cat.#:Gp9-183RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gp9 Protein, His/GST-tagged
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Cat.#:Gp9-184RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gp9 Protein, His-tagged
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Cat.#:GLB1-5396CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GLB1
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Cat.#:GLB1-2329ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GLB1
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Cat.#:GLB1-5909HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GLB1 293 Cell Lysate
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Cat.#:GLB1-5910HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GLB1 293 Cell Lysate
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Involved Pathway

GLB1 involved in several pathways and played different roles in them. We selected most pathways GLB1 participated on our site, such as Galactose metabolism, Other glycan degradation, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Galactose metabolism
AKR1B1L; LALBA; GLA; B4GALT1; GAA; B4GALT2; G6PCA.2; G6PC3; G6PCA.1; UGP2B
Other glycan degradation
GBA2; NEU3.1; MAN2B2; NEU3.2; FUCA1; NEU4; NEU1; FUCA1.2; HEXDC; FUCA1.1
Glycosaminoglycan degradation
GNSB; GALNS; GNS; HGSNAT; SPAM1; HYAL1; IDUA; HYAL4; HEXB; HYAL2
Sphingolipid metabolism
ARSA; NEU3.2; FA2H; ENPP7; B4GALT6; PPAP2CB; CERS4A; GLB1; PPAP2C; SPTLC2
Glycosphingolipid biosynthesis - ganglio series
ST3GAL1; ST6GALNAC5; ST6GALNAC3; ST6GALNAC6; ST6GALNAC4; B4GALNT1; GLB1; HEXA; ST3GAL2; ST8SIA5
Metabolic pathways
PLB1; ATP6V1E1B; PIK3C2A; MT-ND1; IMPDH1B; PLA2G3; PYCR1B; SGMS1; FPGS; GFPT2
Lysosome
CTSW; SORT1B; ATP6V0D1; NAPSA; PLA2G15; CTSA; ATP6V0D2; M6PR; NPC1; AP1M3

Protein Function

GLB1 has several biochemical functions, for example, beta-galactosidase activity, galactoside binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLB1 itself. We selected most functions GLB1 had, and list some proteins which have the same functions with GLB1. You can find most of the proteins on our site.
Function
Related Protein
Function beta-galactosidase activity
Related Protein GLB1L3; GBA3; GLB1; GLB1L2; GLB1L
Function galactoside binding
Related Protein LGALS2; LGALS2A; GLA; LGALS9L1; LGALS1L1; GLB1; LGALS2B; LGALS3L
Function protein binding
Related Protein COA6; CTDNEP1; ITK; SUGT1; DENR; NSL1; EFHA1; H2AFY; ARFGAP3; TBCEL

Interacting Protein

GLB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLB1.
CTNNBIP1; FOS; TK1; PLK1; CSNK2B; NEU1; A2M; cona_canen; ELN; H2AFX