gli2
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  • Official Full Name
  • GLI family zinc finger 2
  • Background
  • This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GLI2; GLI family zinc finger 2; HPE9; THP1; THP2; zinc finger protein GLI2; oncogene GLI2; tax helper protein 1; tax helper protein 2; GLI-Kruppel family member GLI2; tax-responsive element-2 holding protein; glioma-associated oncogene family zinc finger 2; tax-responsive element-25-bp sequence binding protein;
Cat.#:GLI2-2038HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GLI2 Protein (412-641 aa), His-tagged
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Cat.#:GLI2-133HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLI2 protein, His/sumo-tagged
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Cat.#:GLI2-526HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLI2 protein, His-tagged
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Cat.#:GLI2-6402MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GLI2 Protein
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Cat.#:GLI2-4673CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GLI2
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Cat.#:GLI2-4674CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GLI2
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Involved Pathway

GLI2 involved in several pathways and played different roles in them. We selected most pathways GLI2 participated on our site, such as Hedgehog signaling pathway, Hippo signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hedgehog signaling pathway
Shh; CSNK1G2; HHIP; BMP2; DYRK1A; DHH; PRKACAA; GSK3B; PRKACBB; WNT7A
Hippo signaling pathway
TEAD1; LIMD1; DVL3; WWC1; CTGF; TGFB3; AREG; FZD8; ACTG1; SNAI2
Pathways in cancer
PRKACG; RUNX1; WNT5A; WNT5B; APC; NKX3-1; EP300; SUFU; NTRK1; TCEB1
Basal cell carcinoma
WNT7B; APC2; GLI3; WNT8B; DVL1; FZD7; TCF7L2; FZD1; WNT2B; TP53

Protein Function

GLI2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI2 itself. We selected most functions GLI2 had, and list some proteins which have the same functions with GLI2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein EBF2; NKX6; RBPJL; PRDM5; HHEX; CTCF; GMEB1; TFAP2A; POU2F3; NKX3-2
Function chromatin binding
Related Protein KLF6A; NCOA5; POU4F2; NUPR1; HMGB1A; HHEX; NCAPD2; TWIST2; HDAC2; EP300
Function protein binding
Related Protein FIP1L1; DLL4; PLK1S1; RNMT; NPY2R; NEK11; BASP1; SFRP1; SH2B2; SNX20
Function sequence-specific DNA binding
Related Protein INSM1A; RXRGA; DBX2; ZSCAN10; NFYB; HOXC12; FOXA; EOMES; RARAB; MAFBA
Function transcription factor activity, sequence-specific DNA binding
Related Protein JUN; ZNF454; POU5F3; ZEB1; FOXB1B; RXRGA; PURBB; PROX1; LEF1; NFE2L1A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein STK16; OTX2; HOXC13; NR6A1; TRP53; NRF1; MEF2B; POU1F1; TP53; PATZ1
Function zinc ion binding
Related Protein ZRANB3; MLL1; PHF8; BAZ1B; CA3; MMP9; ZCWPW2; DZIP3; OTUD7B; LIG3

Interacting Protein

GLI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI2.
BTRC; SMAD3; SMAD2; YWHAZ; SMAD4

GLI2 Related Articles

Paulo, SS; Fernandes-Rosa, FL; et al. Sonic Hedgehog mutations are not a common cause of congenital hypopituitarism in the absence of complex midline cerebral defects. CLINICAL ENDOCRINOLOGY 82:562-569(2015).
Memmi, EM; Sanarico, AG; et al. p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3499-3504(2015).