gpc6
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  • Official Full Name
  • glypican 6
  • Background
  • The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.
  • Synonyms
  • GPC6; glypican 6; glypican-6; glypican proteoglycan 6; OMIMD1; MGC126288
Cat.#:GPC6-13417HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPC6, His-tagged
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Cat.#:GPC6-5629HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human Glypican 6, His-tagged
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Cat.#:GPC6-5811HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GPC6 293 Cell Lysate
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Involved Pathway

GPC6 involved in several pathways and played different roles in them. We selected most pathways GPC6 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, Chondroitin sulfate/dermatan sulfate metabolism, Defective B3GALT6 causes EDSP2 and SEMDJL1, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
A tetrasaccharide linker sequence is required for GAG synthesis
GPC1B; DCN; GPC5; NCAN; BGN; CSPG5B; CSPG4; VCAN; GPC1A; BCAN
Chondroitin sulfate/dermatan sulfate metabolism
VCANB; NCAN; GPC1B; CSPG5; CHST9; CHST14; AGRN; B4GALT7; BGN; GPC6
Defective B3GALT6 causes EDSP2 and SEMDJL1
NCAN; GPC5; VCAN; CSPG4; AGRN; GPC6; BGN; BCAN; DCN; CSPG5
Defective B3GAT3 causes JDSSDHD
BCAN; GPC6; GPC5; AGRN; DCN; CSPG5; BGN; NCAN; VCAN; CSPG4
Defective B4GALT7 causes EDS, progeroid type
GPC5; BGN; VCAN; AGRN; NCAN; CSPG5; CSPG4; BCAN; DCN; GPC6
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
GPC6; AGRN; GPC5
Defective EXT2 causes exostoses 2
GPC6; AGRN; GPC5
Disease
IPO5; gag; OPN1MW2; FMOD; TH1L; KPNA4; FDX1L; CPSF4; CFTR; MTRR

Protein Function

GPC6 has several biochemical functions, for example, heparan sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPC6 itself. We selected most functions GPC6 had, and list some proteins which have the same functions with GPC6. You can find most of the proteins on our site.
Function
Related Protein
Function heparan sulfate proteoglycan binding
Related Protein AZU1; Gpc2; ITGAM; GPC4; GPC6; SLIT2; HPSE2; AGRN; Itgam&Itgb2; GPC5A

Interacting Protein

GPC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPC6.
GABARAP; GABARAPL2; GABARAPL1

GPC6 Related Articles

Gromova, P; Ralea, S; et al. Kit K641E oncogene up-regulates Sprouty homolog 4 and Trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13:1536-1548(2009).