gpd1
Share
  • Official Full Name
  • glycerol-3-phosphate dehydrogenase 1 (soluble)
  • Background
  • This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
  • Synonyms
  • GPD1; glycerol-3-phosphate dehydrogenase 1 (soluble); GPD-C; HTGTI; GPDH-C; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerophosphate dehydrogenase; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic;
Cat.#:GPD1-5151HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GPD1 Protein, GST-tagged
+Inquiry
Cat.#:GPD1-16HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPD1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:GPD1-17HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPD1 protein, His-tagged
+Inquiry
Cat.#:GPD1-1942HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycerol-3-phosphate dehydrogenase 1 (soluble)
+Inquiry
Cat.#:GPD1-221HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GPD1
+Inquiry
Cat.#:GPD1-26093THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPD1
+Inquiry
Cat.#:GPD1-281HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPD1, His tagged
+Inquiry
Cat.#:GPD1-7106MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GPD1 Protein
+Inquiry
Cat.#:GPD1-2635RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GPD1 Protein
+Inquiry
Cat.#:GPD1-5809HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GPD1 293 Cell Lysate
+Inquiry
Cat.#:CBCRY30Tag:N/A
Source (Host):E. coliSpecies:
Product nameGlycerol-3-phosphate Dehydrogenase [NAD+], Cytoplasmic
+Inquiry

Involved Pathway

GPD1 involved in several pathways and played different roles in them. We selected most pathways GPD1 participated on our site, such as Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
AGPAT5; LCAT; TAE1; DGKG; CRLS1; CHKA; AGPAT3; DGKD; GPD2; PTDSS1A

Protein Function

GPD1 has several biochemical functions, for example, NAD binding, glycerol-3-phosphate dehydrogenase [NAD+] activity, glycerol-3-phosphate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPD1 itself. We selected most functions GPD1 had, and list some proteins which have the same functions with GPD1. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein IDH2; PARP1; AOX3; UGDH; HIBADHA; BDH2; HSD11B2; GPD1L; TESCA; AOX4
Function glycerol-3-phosphate dehydrogenase [NAD+] activity
Related Protein GPD1B; GPD1C; TESCA; GPD1; GPD1L; GPD1A
Function glycerol-3-phosphate dehydrogenase activity
Related Protein GPD1; GPD2
Function oxidoreductase activity
Related Protein H2-KE6; OXR1; CYP2AA3; ALOX12E; GLUD1A; FOXRED1; CYP8B2; CYP2K6; HADHAB; ALDH9A1B
Function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Related Protein CTBP2; GRHPRA; HMGCRB; UEVLD; CTBP2L; MDH1AA; TESCA; FAM213B; CTBP1; LDHBB
Function protein homodimerization activity
Related Protein ZNF174; QDPR; BHLHE40; E2F8; RCHY1; SPATA24; TGFB2; CHUK; GDNFA; ZFP365

Interacting Protein

GPD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPD1.
Ywhae; Ywhaz; Kcnma1; Hsd3b4; Dlg4; Pgls; Hsd3b7

GPD1 Related Articles

Kilfoil, PJ; Tipparaju, SM; et al. Regulation of Ion Channels by Pyridine Nucleotides. CIRCULATION RESEARCH 112:721-741(2013).
Ho, JN; Choi, JW; et al. Kefir inhibits 3T3-L1 adipocyte differentiation through down-regulation of adipogenic transcription factor expression. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 93:485-490(2013).