gpx4
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  • Official Full Name
  • glutathione peroxidase 4
  • Background
  • This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Synonyms
  • GPX4; glutathione peroxidase 4; MCSP; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxidase; sperm nucleus glutathione peroxidase;
Cat.#:GPX4-29080THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX4 Protein
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Cat.#:GPX4-1903PTag:His-SUMO
Source (Host):E. coliSpecies:Pongo Pygmaeus
Product nameRecombinant Pongo Pygmaeus GPX4 Protein (1-170 aa), His-SUMO-tagged
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Cat.#:GPX4-5311HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX4 Protein
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Cat.#:GPX4-13510HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX4, GST-tagged
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Cat.#:GPX4-29076THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX4, His-tagged
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Cat.#:GPX4-8203HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GPX4 protein, His & GST-tagged
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Cat.#:Gpx4-8204MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gpx4 protein, His & T7-tagged
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Cat.#:GPX4-2679RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GPX4 Protein
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Cat.#:GPX4-308HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human GPX4 lysate
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Involved Pathway

GPX4 involved in several pathways and played different roles in them. We selected most pathways GPX4 participated on our site, such as Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
GSTA; GCLM; GSTA4; IDH1; ODC1; GPX2; SMS; GPX1; IDH2; GGCTA

Protein Function

GPX4 has several biochemical functions, for example, glutathione peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX4 itself. We selected most functions GPX4 had, and list some proteins which have the same functions with GPX4. You can find most of the proteins on our site.
Function
Related Protein
Function glutathione peroxidase activity
Related Protein MGST3; GPX8; PRDX6; GPX1; GRX2; GPX6; GPX3; GPX7; GPX1A; GPX1B
Function phospholipid-hydroperoxide glutathione peroxidase activity
Related Protein GPX4; GPX1

Interacting Protein

GPX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX4.
OTUD5; MAPK13; PRDX6