grb10
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  • Official Full Name
  • growth factor receptor-bound protein 10
  • Background
  • Growth factor receptor-bound protein 10 and the insulin-like growth factor and the extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways in HEK 293T cells,In vivo. However, many aspects of the Grb10 adapter function remain unclear. Further research is still required to elucidate and validate the interactions and effects of GRB10 with various cellular targets.
  • Synonyms
  • GRB10; growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR; RSS; IRBP; MEG1; GRB-IR; Grb-10; KIAA0207
Cat.#:GRB10-2233HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GRB10 Protein, MYC/DDK-tagged
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Cat.#:GRB10-246HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB10 Protein, His-tagged
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Cat.#:GRB10-5035HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB10 Protein, GST-tagged
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Cat.#:GRB10-13518HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB10, GST-tagged
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Cat.#:GRB10-1856HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB10, GST-tagged
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Cat.#:GRB10-7245MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRB10 Protein
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Cat.#:GRB10-1970RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GRB10 Protein, His-tagged
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Cat.#:GRB10-3345CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRB10
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Cat.#:GRB10-751HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB10 cell lysate
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Involved Pathway

GRB10 involved in several pathways and played different roles in them. We selected most pathways GRB10 participated on our site, such as EGFR1 Signaling Pathway, IGF1 pathway, IRS activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB10 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
EGFR1 Signaling Pathway
TNIP1; KRT8; RALBB; SH3BGRL; CEBPA; SH2D3C; RALBP1; ZFP259; DOK2; CEACAM1
IGF1 pathway
GNB2L1; GRB10
IRS activation
GRB10; GRB10A
Insulin Pathway
EXOC5; DOK1; EXOC3; GRB14; GRB10; EXOC1; EXOC6
Insulin Signaling
EHD1; RRAD; STXBP3; MYO1C; STXBP4; GRB10; SGK2; SNAP25A; MAP3K2; STXBP1A
Insulin receptor signalling cascade
GRB10A; C7orf59; RRAGB; GRB10; LAMTOR1; RRAGA
Kit Receptor Signaling Pathway
PTPRUB; SPRED2B; DOK1B; SOCS4; DOK1; PTPRU; GRB10; GRB7; GRAPA; STAP1
PDGFR-beta signaling pathway
SLA; GRB10; DOK1; SNX15; SLC9A3R1

Protein Function

GRB10 has several biochemical functions, for example, SH3/SH2 adaptor activity, insulin receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB10 itself. We selected most functions GRB10 had, and list some proteins which have the same functions with GRB10. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein CRKL; SH2D1A; NCK2; GRB14; EPS8; BLNK; SRC; SH2B2; ARHGAP1; LASP1
Function insulin receptor binding
Related Protein ENPP1; INS1; DOK4; DOK1; INS; DOK5; GRB10; IGF2; IGF1R; PTPN11
Function protein binding
Related Protein SEC23IP; RASSF3; TMEM8B; APBA3; ROS1; PACSIN3; VAPB; LDHD; ERN1; EIF3E

Interacting Protein

GRB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB10.
EGFR; INSR; RCAN3; IGF1R; EPHB1; BAIAP2; ABI1; GRB2; ZDHHC17; NOA1

GRB10 Related Articles

Gorlova, O; Martin, JE; et al. Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLOS GENETICS 7:-(2011).
Higashi, S; Iseki, E; et al. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. JOURNAL OF NEUROCHEMISTRY 115:423-437(2010).