GRIK1 Protein, glutamate receptor, ionotropic, kainate 1


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Official Full Name glutamate receptor, ionotropic, kainate 1
Background Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Synonyms GRIK1; glutamate receptor, ionotropic, kainate 1; GLUR5; glutamate receptor, ionotropic kainate 1; GluK1; gluR-5; glutamate receptor 5; excitatory amino acid receptor 3; EAA3; EEA3; GLR5
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rat
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRIK1-28537TH Recombinant Human GRIK1 Wheat Germ N/A
    Human GRIK1-5336H Recombinant Human GRIK1 Protein, GST-tagged Wheat Germ GST
    Rat GRIK1-2695R Recombinant Rat GRIK1 Protein Mammalian Cell His
    Cynomolgus Monkey GRIK1-566C Recombinant Cynomolgus GRIK1 Protein, His-tagged Mammalian Cell His

    GRIK1 involved in several pathways and played different roles in them. We selected most pathways GRIK1 participated on our site, such as Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction P2RX3; SSTR2; MC5R; LPAR6A; TAAR7F; LHCGR; NPY7R; F2RL2; P2RX2; CHRNA4
    Glutamatergic synapse GNG8; GLS; GNB2; SLC1A1; GRM7; ITPR1; PPP3CA; PRKCA; SLC17A7; GRIK4

    GRIK1 has several biochemical functions, for example, drug binding, extracellular-glutamate-gated ion channel activity, glutamate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK1 itself. We selected most functions GRIK1 had, and list some proteins which have the same functions with GRIK1. You can find most of the proteins on our site.

    Function Related Protein
    drug binding P2RX4; CHRNB4; HTR2B; ABP1; HTR2A; ATP5O; TYMS; P2RX2; TLR7; FNTB
    extracellular-glutamate-gated ion channel activity GRIN2B; GRIA2; GRIN3A; GRIA3; GRIA4; GRIN2A; GRIN1; GRIN2D; GRIA2B; GRID2
    glutamate binding GRIN1; GRM7; GLUL; SLC1A3; GAD2; CPS1; GRIK1; GRIN2A; GCLC; SLC1A1
    kainate selective glutamate receptor activity GRIK3; GRIK2; GRIK5; GRIK4; GRIK1
    protein homodimerization activity BCL2A1; CTBP2A; CD8A; ACTN2; GJC3; NR0B2; PAH; HMGCR; PON3; RNF40
    voltage-gated cation channel activity PKD2; GRIN2A; GRIN1; GRIK1; HVCN1

    GRIK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK1.

    Kranzler, HR; Armeli, S; et al. GRIK1 Genotype and Daily Expectations of Alcohol's Positive Effects Moderate the Reduction of Heavy Drinking by Topiramate. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY 22:494-501(2014).
    Kranzler, HR; Wetherill, R; et al. Posttreatment Effects of Topiramate Treatment for Heavy Drinking. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:3017-3023(2014).

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