|Official Full Name||glutamate receptor, ionotropic, kainate 1|
|Background||Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.|
|Synonyms||GRIK1; glutamate receptor, ionotropic, kainate 1; GLUR5; glutamate receptor, ionotropic kainate 1; GluK1; gluR-5; glutamate receptor 5; excitatory amino acid receptor 3; EAA3; EEA3; GLR5|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
GRIK1 involved in several pathways and played different roles in them. We selected most pathways GRIK1 participated on our site, such as Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Neuroactive ligand-receptor interaction||P2RX3; SSTR2; MC5R; LPAR6A; TAAR7F; LHCGR; NPY7R; F2RL2; P2RX2; CHRNA4|
|Glutamatergic synapse||GNG8; GLS; GNB2; SLC1A1; GRM7; ITPR1; PPP3CA; PRKCA; SLC17A7; GRIK4|
GRIK1 has several biochemical functions, for example, drug binding, extracellular-glutamate-gated ion channel activity, glutamate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK1 itself. We selected most functions GRIK1 had, and list some proteins which have the same functions with GRIK1. You can find most of the proteins on our site.
|drug binding||P2RX4; CHRNB4; HTR2B; ABP1; HTR2A; ATP5O; TYMS; P2RX2; TLR7; FNTB|
|extracellular-glutamate-gated ion channel activity||GRIN2B; GRIA2; GRIN3A; GRIA3; GRIA4; GRIN2A; GRIN1; GRIN2D; GRIA2B; GRID2|
|glutamate binding||GRIN1; GRM7; GLUL; SLC1A3; GAD2; CPS1; GRIK1; GRIN2A; GCLC; SLC1A1|
|kainate selective glutamate receptor activity||GRIK3; GRIK2; GRIK5; GRIK4; GRIK1|
|protein homodimerization activity||BCL2A1; CTBP2A; CD8A; ACTN2; GJC3; NR0B2; PAH; HMGCR; PON3; RNF40|
|voltage-gated cation channel activity||PKD2; GRIN2A; GRIN1; GRIK1; HVCN1|
GRIK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK1.