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GRM8

Official Full Name

glutamate receptor, metabotropic 8
Overview

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms

GRM8; glutamate receptor, metabotropic 8; metabotropic glutamate receptor 8; GLUR8; GPRC1H; mGlu8; MGLUR8; FLJ41058; Glutamate receptor metabotropic 8; GRM8_HUMAN; MGC126724; MGR8; OTTHUMP00000024506; OTTHUMP00000069010; OTTHUMP00000199504; OTTHUMP00000212423;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRM8-28274TH	Recombinant Human GRM8	Wheat Germ	N/A	90 amino acids	Inquiry
Human	GRM8-13546H	Recombinant Human GRM8, His-tagged	E.coli	His	31-400a.a.	$319 / 25ug
Human	GRM8-5731HCL	Recombinant Human GRM8 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GRM8-5374H	Recombinant Human GRM8 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Rat	GRM8-2719R	Recombinant Rat GRM8 Protein	Mammalian Cell	His		Inquiry
Rat	GRM8-2373R-B	Recombinant Rat GRM8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	GRM8-2373R	Recombinant Rat GRM8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GRM8-1978R	Recombinant Rhesus monkey GRM8 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	GRM8-1799R-B	Recombinant Rhesus Macaque GRM8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	GRM8-1799R	Recombinant Rhesus Macaque GRM8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GRM8 Related Articles

GRM8 involved in several pathways and played different roles in them. We selected most pathways GRM8 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phospholipase D signaling pathway	AVP;DGKD;PTPN11;GRM4;INSR;RAF1;GRM2;GNAS;AVPR1A
Neuroactive ligand-receptor interaction	GABRA2;GRIK4;TAAR15;TAAR14J;CHRM5A;GPR156;EDNRAA;THRB;CHRND
Glutamatergic synapse	GRIA2;PLD1;GRM6;PLA2G4A;PPP3CB;GLUL;GLS;GRIK2;Adcy4

GRM8 has several biochemical functions, for example, G-protein coupled receptor activity, glutamate receptor activity, group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM8 itself. We selected most functions GRM8 had, and list some proteins which have the same functions with GRM8. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor activity	OR51D1;OLFR495;PRLHR;GPR186;OPN1SW;OPN1LW1;OPNP;PTH1RA;F2RL1
glutamate receptor activity	GRIA1;GRM8;GRM1;GRM4;GRM6;GRIK3;GRIK5;GRM5;GRM7
group III metabotropic glutamate receptor activity	GRM6;GRM7;GRM6A;GRM8;GRM4;GRM6B

GRM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM8.

Raab, M; Boeckers, TM; et al. PROLINE-RICH SYNAPSE-ASSOCIATED PROTEIN-1 AND 2 (ProSAP1/Shank2 AND ProSAP2/Shank3)-SCAFFOLDING PROTEINS ARE ALSO PRESENT IN POSTSYNAPTIC SPECIALIZATIONS OF THE PERIPHERAL NERVOUS SYSTEM. NEUROSCIENCE 171:421-433(2010).

Yang, XR; Zhang, Y; et al. Involvement of group III metabotropic glutamate receptors in the modulation of spinal nociceptive signals. NEURAL REGENERATION RESEARCH 4:443-448(2009).