grm8
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  • Official Full Name
  • glutamate receptor, metabotropic 8
  • Background
  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms
  • GRM8; glutamate receptor, metabotropic 8; metabotropic glutamate receptor 8; GLUR8; GPRC1H; mGlu8; MGLUR8; FLJ41058; Glutamate receptor metabotropic 8; GRM8_HUMAN; MGC126724; MGR8; OTTHUMP00000024506; OTTHUMP00000069010; OTTHUMP00000199504; OTTHUMP00000212423
Cat.#:GRM8-5374HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRM8 Protein, GST-tagged
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Cat.#:GRM8-13546HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRM8, His-tagged
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Cat.#:GRM8-28274THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GRM8
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Cat.#:GRM8-2719RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRM8 Protein
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Cat.#:GRM8-1978RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GRM8 Protein, His-tagged
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Cat.#:GRM8-5731HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRM8 293 Cell Lysate
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Involved Pathway

GRM8 involved in several pathways and played different roles in them. We selected most pathways GRM8 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phospholipase D signaling pathway
CYTH4; CYTH1; GRM1; GRM3; AGTR1B; LPAR3; CXCR1; FYN; RHEB; AKT1
Neuroactive ligand-receptor interaction
GRM6B; GRIA4B; MCHR1; EDNRAA; ADRA2DA; ADCYAP1R1A; ADRB2B; P2RX8; NPFFR2.1; CHRNE
Glutamatergic synapse
PRKCA; GRIA3; GRIN2B; GRIK2; GNG13; PLD2; ITPR3; SHANK3; GRM1; GNB3

Protein Function

GRM8 has several biochemical functions, for example, G-protein coupled receptor activity, glutamate receptor activity, group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM8 itself. We selected most functions GRM8 had, and list some proteins which have the same functions with GRM8. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein OR4D6; OPN1SW; GPR158; OR11A1; GHSRA; OLFR5; MRGPRF; GPR21; CALCRLA; OR10W1
Function glutamate receptor activity
Related Protein GRM8; GRM6; GRIA1; GRM2; GRM5; GRM1; GRM4; GRIK3; GRM3; GRID2
Function group III metabotropic glutamate receptor activity
Related Protein GRM6A; GRM6B; GRM6; GRM7; GRM4; GRM8

GRM8 Related Articles

Raab, M; Boeckers, TM; et al. PROLINE-RICH SYNAPSE-ASSOCIATED PROTEIN-1 AND 2 (ProSAP1/Shank2 AND ProSAP2/Shank3)-SCAFFOLDING PROTEINS ARE ALSO PRESENT IN POSTSYNAPTIC SPECIALIZATIONS OF THE PERIPHERAL NERVOUS SYSTEM. NEUROSCIENCE 171:421-433(2010).
Yang, XR; Zhang, Y; et al. Involvement of group III metabotropic glutamate receptors in the modulation of spinal nociceptive signals. NEURAL REGENERATION RESEARCH 4:443-448(2009).