GSTM2

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GSTM2

Official Full Name glutathione S-transferase mu 2 (muscle)
Background Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
Synonyms GSTM2; glutathione S-transferase mu 2 (muscle); glutathione S transferase M2 (muscle); glutathione S-transferase Mu 2; GST4; GST, muscle; GST class-mu 2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-aryltransferase M2; glutathi
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GSTM2-1939H Recombinant Human GSTM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GSTM2-1691H Recombinant Human Glutathione S-Transferase Mu 2 (Muscle), His-tagged Human His
    Human GSTM2-2522H Recombinant Human GSTM2 protein, His-tagged E.coli His
    Human GSTM2-4418H Recombinant Human GSTM2 Protein, GST-tagged Wheat Germ GST
    Human GSTM2-5712HCL Recombinant Human GSTM2 293 Cell Lysate HEK293 N/A
    Human GSTM2-794H Recombinant Human Glutathione S-transferase Mu 2 (Muscle), His-tagged E.coli His
    Mouse GSTM2-7331M Recombinant Mouse GSTM2 Protein Mammalian Cell His
    Mouse Gstm2-735M Recombinant Mouse Gstm2 protein, His & T7-tagged E.coli His/T7
    Rat Gstm2-736R Recombinant Rat Gstm2 protein, His-tagged E.coli His
    Cynomolgus Monkey GSTM2-575C Recombinant Cynomolgus GSTM2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque GSTM2-1992R Recombinant Rhesus monkey GSTM2 Protein, His-tagged Mammalian Cell His
    Chicken GSTM2-6647C Recombinant Chicken GSTM2 Mammalian Cell His
    Chicken GSTM2-737C Recombinant Chicken GSTM2 protein, His-tagged E.coli His

    GSTM2 involved in several pathways and played different roles in them. We selected most pathways GSTM2 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glutathione metabolism GSTP2; G6PD; IDH2; GSTT1; GGT1; GGT5A; MGST1.1; GSTA1; GGT7; GSTM6
    Metabolism of xenobiotics by cytochrome P UGT1A2; HSD11B1; UGT2A3; GSTM; ADH1; UGT2A2; EPHX1; CYP1A; ALDH1A3; DHDH
    Drug metabolism - cytochrome P ALDH3B1; GSTM4; AOX4; GSTT2; ADH1; GSTP1; UGT2B15; GSTM6; UGT2A1; UGT1A9
    Chemical carcinogenesis UGT1A6; GSTA3; CYP2C18; GSTM4; SULT1A2; UGT1A7; ADH1B; CCBL1; UGT1A2; CYP2B19

    GSTM2 has several biochemical functions, for example, enzyme binding, glutathione binding, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM2 itself. We selected most functions GSTM2 had, and list some proteins which have the same functions with GSTM2. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding UGT1A6A; CYP2A4; SPDL1; APBA3; ATF7; ECM1; TSPAN33; UGT1A3; TMBIM6; PPP1R3B
    glutathione binding LANCL1; GSTM7; GSTM4; GSS; GSTM2; PTGESL; MGST1; PTGES; LTC4S; GSTP2
    glutathione transferase activity GSTT1; GSTM6; GSTA4; GSTK1; MGST1; GSTO2; GSTM3; GSTP2; EEF1E1; GSTA1
    protein homodimerization activity TREX1; TOP2A; UGT1A9; PON3; RIPK2; TARS; HES1; TSG101; TESC; LRP6
    receptor binding GIPC1; PVRL2L; NUDT7; WNT4A; GDNF; NRG2B; TENC1; CAT; CDH5; PLAUR

    GSTM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM2.

    Li, YJ; Yan, M; et al. Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation. STEM CELL RESEARCH & THERAPY 5:-(2014).
    Lim, J; Luderer, U; et al. Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary. BIOLOGY OF REPRODUCTION 84:775-782(2011).

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