gstm2
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  • Official Full Name
  • glutathione S-transferase mu 2 (muscle)
  • Background
  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
  • Synonyms
  • GSTM2; glutathione S-transferase mu 2 (muscle); glutathione S transferase M2 (muscle); glutathione S-transferase Mu 2; GST4; GST, muscle; GST class-mu 2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-aryltransferase M2; glutathi
Cat.#:GSTM2-4418HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSTM2 Protein, GST-tagged
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Cat.#:GSTM2-1691HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutathione S-Transferase Mu 2 (Muscle), His-tagged
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Cat.#:GSTM2-2522HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTM2 protein, His-tagged
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Cat.#:GSTM2-27773THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTM2, His-tagged
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Cat.#:GSTM2-7331MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GSTM2 Protein
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Cat.#:Gstm2-735MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gstm2 protein, His & T7-tagged
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Cat.#:Gstm2-736RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gstm2 protein, His-tagged
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Cat.#:GSTM2-575CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GSTM2 Protein, His-tagged
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Cat.#:GSTM2-1992RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GSTM2 Protein, His-tagged
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Cat.#:GSTM2-6647CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GSTM2
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Cat.#:GSTM2-737CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken GSTM2 protein, His-tagged
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Cat.#:GSTM2-794HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutathione S-transferase Mu 2 (Muscle), His-tagged
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Cat.#:GSTM2-5712HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GSTM2 293 Cell Lysate
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Involved Pathway

GSTM2 involved in several pathways and played different roles in them. We selected most pathways GSTM2 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
GGCTA; GPX4; RRM1; GSTM; GPX1; ANPEP; G6PDX; GSTM1; GPX2; G6PD
Metabolism of xenobiotics by cytochrome P
UGT1A1; UGT1A6A; UGT2B7; DHDH; UGT2A1; GSTM7; DHDHL; UGT1A3; CBR2; GSTM6
Drug metabolism - cytochrome P
MGST1; GSTA2; GSTO1; MGST2; MGST1.2; FMO3; UGT1A6; AOX3L1; GSTP1; UGT1A3
Chemical carcinogenesis
SULT1A4; CYP3A5; CYP2C55; CBR1; UGT2B7; GSTA3; CYP3A41B; CYP2E1; UGT2A3; CCBL2

Protein Function

GSTM2 has several biochemical functions, for example, enzyme binding, glutathione binding, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM2 itself. We selected most functions GSTM2 had, and list some proteins which have the same functions with GSTM2. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein H2AFX; PHKG2; TUT1; TARBP2; PRKCE; IQCB1; PICK1; EGLN1; THRB; UBE4B
Function glutathione binding
Related Protein PTGESL; LANCL1; GSTM7; GPX1; GSS; GSTP2; LTC4S; PTGES; PTGES2; GSTM1
Function glutathione transferase activity
Related Protein GSTO1; GDAP1L1; GSTO2; EEF1G; GRX2; GSTT4; GSTK1; GSTA3; GSTM7; HPGDS
Function protein homodimerization activity
Related Protein ACOT7; HSP90AA1; LRP6; SUMF1; ENO3; CAMK2D; Trl; GOT2; NPM1; CRYAB
Function receptor binding
Related Protein TNFSF12; MIF; IL1RAPL1; NPPB; C3; PLAUR; Ren1; Itga10&Itgb1; CD86; NTF7

GSTM2 Related Articles

Li, YJ; Yan, M; et al. Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation. STEM CELL RESEARCH & THERAPY 5:-(2014).
Lim, J; Luderer, U; et al. Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary. BIOLOGY OF REPRODUCTION 84:775-782(2011).