gtf2a2
Share
  • Official Full Name
  • general transcription factor IIA, 2, 12kDa
  • Background
  • Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II;(POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM;189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA;element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both;TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3;subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded;by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2;(DeJong et al., 1995 (PubMed 7724559)).
  • Synonyms
  • GTF2A2; general transcription factor IIA, 2, 12kDa; general transcription factor IIA, 2 (12kD subunit); transcription initiation factor IIA subunit 2; HsT18745; TFIIA; TFIIAS; TFIIA-12; TFIIA-gamma; TFIIA p12 subunit; general transcription factor IIA subu
Cat.#:GTF2A2-4439HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GTF2A2 Protein, GST-tagged
+Inquiry
Cat.#:GTF2A2-27775THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GTF2A2
+Inquiry
Cat.#:GTF2A2-29171THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GTF2A2, His-tagged
+Inquiry
Cat.#:GTF2A2-3000HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human General Transcription Factor IIA, 2, 12kDa, T7-tagged
+Inquiry
Cat.#:GTF2A2-419HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GTF2A2 Protein, His-tagged
+Inquiry
Cat.#:GTF2A2-2740RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GTF2A2 Protein
+Inquiry
Cat.#:GTF2A2-2001RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GTF2A2 Protein, His-tagged
+Inquiry
Cat.#:GTF2A2-3670CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GTF2A2
+Inquiry
Cat.#:GTF2A2-2785ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GTF2A2
+Inquiry
Cat.#:GTF2A2-5704HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GTF2A2 293 Cell Lysate
+Inquiry

Involved Pathway

GTF2A2 involved in several pathways and played different roles in them. We selected most pathways GTF2A2 participated on our site, such as Basal transcription factors, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Basal transcription factors
GTF2B; GTF2E2; TAF5; TAF8; TAF6; GTF2H5; TAF9; TAF3; TAF4B; ERCC3
Viral carcinogenesis
CREB3L1; DNAJA3; SRC; HDAC7; CASP8; HIST1H2BD; MRPS18B; HIST1H2BA; GSN; HDAC7A

Protein Function

GTF2A2 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, TBP-class protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2A2 itself. We selected most functions GTF2A2 had, and list some proteins which have the same functions with GTF2A2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II repressing transcription factor binding
Related Protein RBPJ; SP1; CHD4; DMAP1; MKKS; MIXL1; TBX5A; TTC8; PPARA; GTF2A2
Function TBP-class protein binding
Related Protein DR1; BRF1; EFCAB11; PSMC1A; PSMC6; PSMC4; TAF1; GTF2A1; PSMC5; HHEX
Function protein binding
Related Protein FBL; IL15RA; SSSCA1; SGCG; MAP3K5; MBNL3; FIGNL1; HIST3H3; GABBR2; PFDN4
Function protein heterodimerization activity
Related Protein ADRA1B; TLX1; ATF3; CYBB; MAP3K7; SDCBP2; TAL1; OSTB; HIST1H4B; TCF3A
Function protein homodimerization activity
Related Protein DRD2; SMAGP; PRPS1; AADAT; MID2; GALE; TENM1; GDF6; JUP; DARS2
Function transcription coactivator activity
Related Protein FUS; MAGED1; CEBPA; MTA1; FHL5; TADA2A; SUB1; PIAS1; SETD3; UTF1
Function transcription factor binding
Related Protein RBFOX2; KEAP1; PIAS2; CEBPA; KEAP1B; NR0B2; NAAA; NKX2-1; RBPJ; HTT

Interacting Protein

GTF2A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2A2.
GTF2A1; TBP; GTF2A1; TBPL1