GTF2A2 Protein, general transcription factor IIA, 2, 12kDa


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Official Full Name general transcription factor IIA, 2, 12kDa
Background Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II;(POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM;189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA;element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both;TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3;subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded;by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2;(DeJong et al., 1995 (PubMed 7724559)).
Synonyms GTF2A2; general transcription factor IIA, 2, 12kDa; general transcription factor IIA, 2 (12kD subunit); transcription initiation factor IIA subunit 2; HsT18745; TFIIA; TFIIAS; TFIIA-12; TFIIA-gamma; TFIIA p12 subunit; general transcription factor IIA subu
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GTF2A2-27775TH Recombinant Human GTF2A2 E.coli N/A
    Human GTF2A2-29171TH Recombinant Human GTF2A2, His-tagged E.coli His
    Human GTF2A2-3000H Recombinant Human General Transcription Factor IIA, 2, 12kDa, T7-tagged E.coli T7
    Human GTF2A2-419H Recombinant Human GTF2A2 Protein, His-tagged E.coli His
    Human GTF2A2-4439H Recombinant Human GTF2A2 Protein, GST-tagged Wheat Germ GST
    Human GTF2A2-5704HCL Recombinant Human GTF2A2 293 Cell Lysate HEK293 N/A
    Rat GTF2A2-2740R Recombinant Rat GTF2A2 Protein Mammalian Cell His
    Rhesus Macaque GTF2A2-2001R Recombinant Rhesus monkey GTF2A2 Protein, His-tagged Mammalian Cell His
    Chicken GTF2A2-3670C Recombinant Chicken GTF2A2 Mammalian Cell His
    Zebrafish GTF2A2-2785Z Recombinant Zebrafish GTF2A2 Mammalian Cell His

    GTF2A2 involved in several pathways and played different roles in them. We selected most pathways GTF2A2 participated on our site, such as Basal transcription factors, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal transcription factors TAF13; CCNH; GTF2H1; TBP; TAF9; ERCC3; TBPL1; TAF2; GTF2F2; TAF5L
    Viral carcinogenesis GTF2B; H2BFWT; SND1; LTBR; HLA-E; CREB3L2; GRB2; BAX; HIST1H4E; HIST1H4K

    GTF2A2 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, TBP-class protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2A2 itself. We selected most functions GTF2A2 had, and list some proteins which have the same functions with GTF2A2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II repressing transcription factor binding BBS5; SIN3A; TTC8; TCF7L2; BBS2; GTF2A2; BBS10; CHD4; STAT3; BBS4
    TBP-class protein binding DR1; CAND2; PSMC3; PSMC5; PSMC1; EFCAB11; BRF1A; TAF1B; TAF1L; GTF2A1
    protein binding BCL2L11; NUP50; DDX39B; CTNNB2; SMURF2; ZNHIT1; POMGNT1; RELA; MBL2; NEDD9
    protein heterodimerization activity HIST1H2A9; PANX2; KATNB1; Pdgfa&Pdgfb; SAE1; ENO3; VAPB; HIST1H4E; ABCG1; HIST1H4K
    protein homodimerization activity SLC6A4; PDXK; FIGF; TSG101; PRPS1; AADAT; NR4A3; SMAD3; C1QB; CAMK2B
    transcription coactivator activity AIP; TGFB1I1; SUPT7L; RXRA; PSMD9; NFKBIB; IL31RA; CALCOCO1; ENY2; MED27
    transcription factor binding SOX8; LEF1; CEBPG; PPID; PPP1R13BA; SP1; GATA6; HES2; WWP2; KAT2B

    GTF2A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2A2.

    GTF2A1; TBP; GTF2A1; TBPL1

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