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MGEA5

  • Official Full Name

    meningioma expressed antigen 5 (hyaluronidase)

  • Overview

    The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and;removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a;glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 (PubMed 11148210)).
  • Synonyms

    MGEA5; meningioma expressed antigen 5 (hyaluronidase); bifunctional protein NCOAT; MEA5; NCOAT; nuclear cytoplasmic O GlcNAcase and acetyltransferase; OGA; Glycoside hydrolase O-GlcNAcase; HAT; HEXC; Hexosaminidase C; Histone acetyltransferase; KIAA0679; Meningioma expressed antigen 5; Meningioma-expressed antigen 5; MGEA 5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; NCOAT_HUMAN; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; O-GlcNAcase; hyaluronidase in meningioma;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MGEA5-864H Recombinant Human MGEA5, His-tagged E.coli His 1-350aa
Human MGEA5-612H Recombinant Human MGEA5 protein, His-tagged E.coli His Ser6~Lys240
Human MGEA5-86H Recombinant Human MGEA5, MYC/DDK-tagged HEK293 Myc/DDK
Human MGEA5-1108HCL Recombinant Human MGEA5 cell lysate N/A
Human MGEA5-2438H Recombinant Human MGEA5 Protein, His-tagged E.coli N-His Ser6-Thr450
Human MGEA5-8207HFL Recombinant Full Length Human MGEA5, Flag-tagged Mamanlian cells Flag
Human MGEA5-5301H Recombinant Human MGEA5 Protein, GST-tagged Wheat Germ GST
Human MGEA5-6514HF Recombinant Full Length Human MGEA5 Protein, GST-tagged In Vitro Cell Free System GST 916 amino acids
Mouse MGEA5-9814M Recombinant Mouse MGEA5 Protein Mammalian Cell His
Mouse Mgea5-614M Recombinant Mouse Mgea5 protein, His-tagged E.coli His Arg83~Thr222 (Accession # Q9EQQ9)
Mouse MGEA5-5538M Recombinant Mouse MGEA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MGEA5-5538M-B Recombinant Mouse MGEA5 Protein Pre-coupled Magnetic Beads HEK293
Rat MGEA5-3672R Recombinant Rat MGEA5 Protein Mammalian Cell His
Rat Mgea5-617R Recombinant Rat Mgea5 protein, His-tagged E.coli His Ala19~Thr222 (Accession # Q8VIJ5)
Rat MGEA5-3328R-B Recombinant Rat MGEA5 Protein Pre-coupled Magnetic Beads HEK293
Rat MGEA5-3328R Recombinant Rat MGEA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken MGEA5-3365C Recombinant Chicken MGEA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MGEA5 involved in several pathways and played different roles in them. We selected most pathways MGEA5 participated on our site, such as Insulin resistance, protein O-[N-acetyl]-glucosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGEA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Insulin resistanceRPS6KAL;SOCS3;G6PCA.2;INSRA;GYS1;INS1;AKT1;PRKCDA;G6PCA.1
protein O-[N-acetyl]-glucosylation

MGEA5 has several biochemical functions, for example, beta-N-acetylglucosaminidase activity, histone acetyltransferase activity, hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGEA5 itself. We selected most functions MGEA5 had, and list some proteins which have the same functions with MGEA5. You can find most of the proteins on our site.

Function Related Protein
beta-N-acetylglucosaminidase activity
histone acetyltransferase activityKAT7;NCOA1;KAT2B;METTL8;CLOCK;CSRP2BP;KAT8;EP300;MED24
hyalurononglucosaminidase activityKIAA1199;SPAM1;HYAL1;HYAL4;HYAL2;HYAL6;HYAL3;CD44;MGEA5

MGEA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGEA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGEA5.

MDM2; FKBP5; NUDCD3; q96be0_human; CYLD; A2M; GSK3B; HAP1; CSNK2B; CDC37; q5nhh0_fratt; phhA; dAK1_1; SPAG5; RNF32; MAST1; CBX8

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