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HDAC3

  • Official Full Name

    histone deacetylase 3

  • Overview

    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone Deacetylase 3 (HDAC3) belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene that also plays critical roles in S phase progression and DNA damage control.
  • Synonyms

    HDAC3; histone deacetylase 3; HD3; RPD3; RPD3 2; SMAP45; RPD3-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • S.frugiperda
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HDAC3-854H Active Recombinant Human HDAC3, FLAG-tagged Insect Cell Flag
Human HDAC3-394H Active Recombinant Human Histone Deacetylase 3, His GST-tagged Insect Cell His/GST
Human HDAC3-1356H Active Recombinant Human HDAC3, GST-tagged Sf9 Insect Cell GST Full length
Human NCOR1-86H Active Recombinant Human NCOR1, GST-tagged Insect Cell GST
Human HDAC3-743H Recombinant Human HDAC3 Mammalian Cell His
Human HDAC3-8482H Recombinant Human HDAC3, His-tagged Sf21 Insect Cell His
Human HDAC3-758H Recombinant Human Histone Deacetylase 3 S.frugiperda N/A
Human HDAC3-13707H Recombinant Human HDAC3, GST-tagged E.coli GST 187-395a.a.
Human HDAC3-390H Recombinant Human HDAC3, His-tagged Insect Cell His 428 amino acids
Human HDAC3-4643H Recombinant Human HDAC3 Protein, GST-tagged Wheat Germ GST
Human HDAC3-1591H Recombinant Human Histone Deacetylase 3, GST-tagged Sf9 Insect Cell GST
Human HDAC3-3908H Recombinant Human HDAC3, His & GST tagged Insect Cell His/GST
Human HDAC3-94H Recombinant Human HDAC3 Protein, GST-tagged Insect Cell GST
Human HDAC3-56H Recombinant Human HDAC3 protein, His-tagged E.coli His 443aa(including fusion tag)
Human HDAC3-572HCL Recombinant Human HDAC3 cell lysate Insect Cell N/A
Human HDAC3-2235H Recombinant Human HDAC3 Protein, His-tagged E.coli N-His Met1-Ile428
Human HDAC3-550H Recombinant Human HDAC3 Protein (1-428 aa), His-SUMO-tagged E.coli His/SUMO 1-428 aa
Human HDAC3-1054H Recombinant Human HDAC3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HDAC3-46H Recombinant Human HDAC3 Protein, His-tagged Insect Cell His
Human HDAC3-3099H-B Recombinant Human HDAC3 Protein Pre-coupled Magnetic Beads HEK293
Human HDAC3-162H Recombinant Human HDAC3 and NCOR2 Protein, His/GST-tagged Insect cell His/GST
Human HDAC3-6182H Recombinant Human HDAC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HDAC3-3612HF Recombinant Full Length Human HDAC3 Protein, GST-tagged In Vitro Cell Free System GST 428 amino acids
Human HDAC3-3099H Recombinant Human HDAC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HDAC3-3229H Recombinant Human HDAC3 Protein (Met1-Gln376), N-His tagged E.coli N-His Met1-Gln376
Mouse Hdac3-1103M Recombinant Mouse Hdac3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HDAC3-2816R Recombinant Rat HDAC3 Protein Mammalian Cell His
Rat HDAC3-2471R-B Recombinant Rat HDAC3 Protein Pre-coupled Magnetic Beads HEK293
Rat HDAC3-3370R Recombinant Rat HDAC3 protein, His-tagged E.coli His Met1~Ile428
Rat HDAC3-2471R Recombinant Rat HDAC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HDAC3-2054R Recombinant Rhesus monkey HDAC3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HDAC3-1875R Recombinant Rhesus Macaque HDAC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HDAC3-1875R-B Recombinant Rhesus Macaque HDAC3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HDAC3-11224Z Recombinant Zebrafish HDAC3 Mammalian Cell His
Chicken HDAC3-6312C Recombinant Chicken HDAC3 Mammalian Cell His
Kit-2254 HDAC3 Activity Fluorometric Assay Kit N/A
Kit-1739 HDAC3 Kinetic Assay Kit N/A
Kit-2282 HDAC3 Immunoprecipitation (IP) & Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HDAC3 Related Articles
  • HDAC3 Related Research Area
  • HDAC3 Related Signal Pathway

HDAC3 involved in several pathways and played different roles in them. We selected most pathways HDAC3 participated on our site, such as Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Thyroid hormone signaling pathwayPRKCA;RXRA;PIK3R2;ACTG1;PIK3CD;PLN;MED17;PIK3R3;SIN3A
AlcoholismSLC29A1;HIST1H2AK;GM6026;BDNF;HIST1H2AO;HIST1H3G;HRAS;GNG7;H3F3C
Viral carcinogenesisCCND2;IL6ST;TRAF3;SNW1;GTF2A1L;HLA-C;TRAF5;HIST1H2BI;NRAS

HDAC3 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC3 itself. We selected most functions HDAC3 had, and list some proteins which have the same functions with HDAC3. You can find most of the proteins on our site.

Function Related Protein
NAD-dependent histone deacetylase activity (H3-K14 specific)HDAC6;HDAC4;HDAC8;HDAC11;HDAC7;HDAC2;HDAC1;HDAC10;HDAC9
NF-kappaB bindingHSPA6;COMMD6;FOXP3;BRMS1;ANXA4;RELA;HDAC3;NPM1;BCL10
chromatin DNA bindingACTN4;MYOG;GRHL1;EZH2;AASS;PPARGC1A;H2AFY2;VAX2;APEX1
chromatin bindingSTAG2;YAP1;CNBPA;MECP2;CBX1;KAT2B;SATB1;GPR30;RNF168
cyclin bindingCDK6;PFTK1;CDKN1A;CDK2;CDK4;INCA1;CDK14;USP2;CDK12
enzyme bindingPEBP1;CD4;TSPAN10;CASP2;GBP1;CSF3;PTEN;PRKCE;CREB1
histone deacetylase activityMTA2;NACC2;HDAC1;HDAC8;HDAC3;HDAC9B;HDAC11;HDAC2;HDAC10
histone deacetylase bindingHIST1H1B;CRY1;SUDS3;NR2E1;CAMTA2;CEBPA;SKOR2;TFAP4;SRF
protein bindingS100B;ARHGAP4;HMGN4;MYH7;FARS2;HIRIP3;DHX36;MED23;TUBGCP2
protein deacetylase activityHDAC9;SIRT2;HDAC2;HDAC10;SIRT1;HDAC1;HDAC4;HDAC3;HDAC5
transcription corepressor activityPPP1R13L;RLIM;CBFA2T2;MSC;ZHX2;ANKRD1;ZFPM1;SIRT6;NSD1
transcription factor bindingKAT2B;PBX1;HEY1;SUMO1;SORBS3;FOSB;MDFIC;TLE1;CAMTA2

HDAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC3.

NCOR2; NCOR1; KDM1A; L3MBTL2; MAGEA2

Svegliati, S; Marrone, G; et al. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. SCIENCE SIGNALING 7:-(2014).
Hoeksema, MA; Gijbels, MJJ; et al. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO MOLECULAR MEDICINE 6:1124-1132(2014).
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