HDAC3 Protein, histone deacetylase 3


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Official Full Name histone deacetylase 3
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone Deacetylase 3 (HDAC3) belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene that also plays critical roles in S phase progression and DNA damage control.
Synonyms HDAC3; histone deacetylase 3; HD3; RPD3; RPD3 2; SMAP45; RPD3-2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • SUMO
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Hdac3-1103M Recombinant Mouse Hdac3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HDAC3-46H Recombinant Human HDAC3 Protein, His-tagged Insect Cell His
    Human HDAC3-550H Recombinant Human HDAC3 Protein (1-428 aa), His-SUMO-tagged E.coli His/SUMO
    Human HDAC3-1054H Recombinant Human HDAC3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HDAC3-1356H Recombinant Human HDAC3 (Active), GST-tagged Sf9 Insect Cell GST
    Human HDAC3-13707H Recombinant Human HDAC3, GST-tagged E.coli GST
    Human HDAC3-1591H Recombinant Human Histone Deacetylase 3, GST-tagged Sf9 Insect Cell GST
    Human HDAC3-3908H Recombinant Human HDAC3, His & GST tagged Insect Cell His/GST
    Human HDAC3-390H Recombinant Human HDAC3, His-tagged Insect Cell His
    Human HDAC3-394H Recombinant Human Histone Deacetylase 3, His GST-tagged Insect Cell His/GST
    Human HDAC3-4643H Recombinant Human HDAC3 Protein, GST-tagged Wheat Germ GST
    Human HDAC3-56H Recombinant Human HDAC3 protein, His-tagged E.coli His
    Human HDAC3-572HCL Recombinant Human HDAC3 cell lysate Insect Cell N/A
    Human HDAC3-743H Recombinant Human HDAC3 Mammalian Cell His
    Human HDAC3-758H Recombinant Human Histone Deacetylase 3 S.frugiperda N/A
    Human HDAC3-8482H Recombinant Human HDAC3, His-tagged Sf21 Insect Cell His
    Human HDAC3-854H Recombinant Human HDAC3, FLAG-tagged Insect Cell Flag
    Human HDAC3-94H Recombinant Human HDAC3 Protein, GST-tagged Insect Cell GST
    Human NCOR1-86H Recombinant Human NCOR1, GST-tagged Insect Cell GST
    Rat HDAC3-2816R Recombinant Rat HDAC3 Protein Mammalian Cell His
    Rhesus Macaque HDAC3-2054R Recombinant Rhesus monkey HDAC3 Protein, His-tagged Mammalian Cell His
    Chicken HDAC3-6312C Recombinant Chicken HDAC3 Mammalian Cell His
    Zebrafish HDAC3-11224Z Recombinant Zebrafish HDAC3 Mammalian Cell His
    Kit-1739 HDAC3 Kinetic Assay Kit N/A
    Kit-2254 HDAC3 Activity Fluorometric Assay Kit N/A
    Kit-2282 HDAC3 Immunoprecipitation (IP) & Activity Assay Kit N/A

    HDAC3 involved in several pathways and played different roles in them. We selected most pathways HDAC3 participated on our site, such as Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway RCAN1; ACTB; STAT1; ATP1B4; PRKCA; NCOA1; SIN3A; ATP1B3; PIK3CD; ATP1A1
    Alcoholism GNG7; CREB3L3; TH; GNGT1; CALML5; HIST1H3G; GRIN1; GNB1; ATF4; HIST1H3F
    Viral carcinogenesis PIK3CA; TRAF5; ACTN1; HIST1H2BD; HIST2H4; HDAC4; HIST2H2BE; HIST1H4J; GRB2; YWHAZ

    HDAC3 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC3 itself. We selected most functions HDAC3 had, and list some proteins which have the same functions with HDAC3. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC4; HDAC5; HDAC8; HDAC7A; HDAC2; HDAC1; HDAC7; HDAC3; HDAC6; HDAC9
    chromatin DNA binding BCL6; HIST1H1C; VAX2; MYOG; APEX1; SRF; HIST1H1D; HIST1H1A; NKAP; ATOH1
    chromatin binding KIAA0101; SIRT6; EZH2; POLG; BRD4; KDM6B; SMC1A; URI1; JMJD5; SHMT2
    cyclin binding FBXW7; CDK4; HDAC3; CDK12; CUL3; PFTK1; MDFIC; USP2; INCA1; CDK6
    enzyme binding HAND2; EGFR; SELS; POLB; ABCD1; LDB1; PTPN1; PLSCR4; TMBIM6; PARP1
    histone deacetylase activity HDAC10; NACC2; HDAC9; HDAC1; MTA2; SIRT2; ATXN3L; HDAC6; HDAC5; HDAC9B
    histone deacetylase binding HDAC5; SFPQ; NKX3-1; D7ERTD443E; SUDS3; DHX36; CAMTA2; CDC20; ANKRA2; SIRT2
    protein binding IRX1; FGF10; CRTAC1; SKP1; USH1C; RIPK1; BCL2L13; GLI2; SERPINF1; WASL
    protein deacetylase activity HDAC2; HDAC9; SIN3A; HDAC3; HDAC5; SIRT2; HDAC10; HDAC4; HDAC1; SIRT1
    transcription corepressor activity E2F6; AEBP1; CBFA2T2; HDAC7; ZMYND11; HSBP1; E2F8; TLE4; E4F1; FOXP3
    transcription factor binding APBB3; UBA2; GATA6; NFYC; SUFU; FOXO1; MDFI; STK4; HIF1A; PBX1

    HDAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC3.


    Svegliati, S; Marrone, G; et al. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. SCIENCE SIGNALING 7:-(2014).
    Hoeksema, MA; Gijbels, MJJ; et al. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO MOLECULAR MEDICINE 6:1124-1132(2014).

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