|Official Full Name||histone deacetylase 3|
|Background||Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone Deacetylase 3 (HDAC3) belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene that also plays critical roles in S phase progression and DNA damage control.|
|Synonyms||HDAC3; histone deacetylase 3; HD3; RPD3; RPD3 2; SMAP45; RPD3-2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
HDAC3 involved in several pathways and played different roles in them. We selected most pathways HDAC3 participated on our site, such as Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Thyroid hormone signaling pathway||RCAN1; ACTB; STAT1; ATP1B4; PRKCA; NCOA1; SIN3A; ATP1B3; PIK3CD; ATP1A1|
|Alcoholism||GNG7; CREB3L3; TH; GNGT1; CALML5; HIST1H3G; GRIN1; GNB1; ATF4; HIST1H3F|
|Viral carcinogenesis||PIK3CA; TRAF5; ACTN1; HIST1H2BD; HIST2H4; HDAC4; HIST2H2BE; HIST1H4J; GRB2; YWHAZ|
HDAC3 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC3 itself. We selected most functions HDAC3 had, and list some proteins which have the same functions with HDAC3. You can find most of the proteins on our site.
|NAD-dependent histone deacetylase activity (H3-K14 specific)||HDAC4; HDAC5; HDAC8; HDAC7A; HDAC2; HDAC1; HDAC7; HDAC3; HDAC6; HDAC9|
|NF-kappaB binding||HIF1AN; SNAI1A; NFKBID; HSPA6; ANKRD42; BRMS1; ANXA4; PSMA6; FOXP3; TAF4B|
|chromatin DNA binding||BCL6; HIST1H1C; VAX2; MYOG; APEX1; SRF; HIST1H1D; HIST1H1A; NKAP; ATOH1|
|chromatin binding||KIAA0101; SIRT6; EZH2; POLG; BRD4; KDM6B; SMC1A; URI1; JMJD5; SHMT2|
|cyclin binding||FBXW7; CDK4; HDAC3; CDK12; CUL3; PFTK1; MDFIC; USP2; INCA1; CDK6|
|enzyme binding||HAND2; EGFR; SELS; POLB; ABCD1; LDB1; PTPN1; PLSCR4; TMBIM6; PARP1|
|histone deacetylase activity||HDAC10; NACC2; HDAC9; HDAC1; MTA2; SIRT2; ATXN3L; HDAC6; HDAC5; HDAC9B|
|histone deacetylase binding||HDAC5; SFPQ; NKX3-1; D7ERTD443E; SUDS3; DHX36; CAMTA2; CDC20; ANKRA2; SIRT2|
|protein binding||IRX1; FGF10; CRTAC1; SKP1; USH1C; RIPK1; BCL2L13; GLI2; SERPINF1; WASL|
|protein deacetylase activity||HDAC2; HDAC9; SIN3A; HDAC3; HDAC5; SIRT2; HDAC10; HDAC4; HDAC1; SIRT1|
|transcription corepressor activity||E2F6; AEBP1; CBFA2T2; HDAC7; ZMYND11; HSBP1; E2F8; TLE4; E4F1; FOXP3|
|transcription factor binding||APBB3; UBA2; GATA6; NFYC; SUFU; FOXO1; MDFI; STK4; HIF1A; PBX1|
HDAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC3.
NCOR2; NCOR1; KDM1A; L3MBTL2; MAGEA2