hdac3
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  • Official Full Name
  • histone deacetylase 3
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone Deacetylase 3 (HDAC3) belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene that also plays critical roles in S phase progression and DNA damage control.
  • Synonyms
  • HDAC3; histone deacetylase 3; HD3; RPD3; RPD3 2; SMAP45; RPD3-2
Cat.#:HDAC3-550HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC3 Protein (1-428 aa), His-SUMO-tagged
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Cat.#:HDAC3-1054HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HDAC3 Protein, MYC/DDK-tagged
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Cat.#:HDAC3-4643HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC3 Protein, GST-tagged
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Cat.#:HDAC3-1591HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 3, GST-tagged
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Cat.#:HDAC3-13707HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC3, GST-tagged
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Cat.#:HDAC3-3908HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC3, His & GST tagged
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Cat.#:HDAC3-390HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC3, His-tagged
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Cat.#:HDAC3-394HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 3, His GST-tagged
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Cat.#:HDAC3-56HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human HDAC3 protein, His-tagged
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Cat.#:HDAC3-743HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human HDAC3
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Cat.#:HDAC3-758HTag:N/A
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Histone Deacetylase 3
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Cat.#:HDAC3-8482HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC3, His-tagged
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Cat.#:HDAC3-854HTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC3, FLAG-tagged
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Cat.#:HDAC3-94HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC3 Protein, GST-tagged
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Cat.#:NCOR1-86HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human NCOR1, GST-tagged
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Cat.#:HDAC3-2816RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HDAC3 Protein
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Cat.#:HDAC3-2054RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC3 Protein, His-tagged
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Cat.#:HDAC3-6312CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDAC3
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Cat.#:HDAC3-11224ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HDAC3
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Cat.#:HDAC3-1356HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC3 (Active), GST-tagged
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Cat.#:HDAC3-572HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC3 cell lysate
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Cat.#:Kit-1739Tag:
Source (Host):Species:
Product nameHDAC3 Kinetic Assay Kit
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Cat.#:Kit-2254Tag:
Source (Host):Species:
Product nameHDAC3 Activity Fluorometric Assay Kit
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Cat.#:Kit-2282Tag:
Source (Host):Species:
Product nameHDAC3 Immunoprecipitation (IP) & Activity Assay Kit
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Involved Pathway

HDAC3 involved in several pathways and played different roles in them. We selected most pathways HDAC3 participated on our site, such as Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway
PLCB4; STAT1; PIK3R5; RXRA; ITGAV; RXRB; NRAS; PDPK1; PLN; HIF1A
Alcoholism
HIST3H3; PDYN; ARAF; HIST1H2AG; GM14479; ADORA2A; SLC6A3; GNAI2; GM14477; CREB5
Viral carcinogenesis
EIF2AK2; BAD; ATF4; TBPL2; GTF2E1; HIST1H2BN; ACTN3; GTF2A1L; GTF2H2C_2; HIST1H2BE

Protein Function

HDAC3 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC3 itself. We selected most functions HDAC3 had, and list some proteins which have the same functions with HDAC3. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC9; HDAC1; HDAC8; HDAC3; HDAC10; HDAC7; HDAC7A; HDAC5; HDAC2; HDAC4
Function NF-kappaB binding
Related Protein HDAC3; TAF4B; ANXA4; CDKN2A; HDAC1; SNAI1A; HDAC2; RELA; MTDH; CPNE1
Function chromatin DNA binding
Related Protein THRB; ACTN4; EZH2; PRDM14; AASS; GATA1; THRA; HIST1H1D; RXRA; PER1
Function chromatin binding
Related Protein RAN; SMAD2; BRD3; DNAJC2; CRTC2; SNAI2; GATA5; SKIL; NONO; MEF2A
Function cyclin binding
Related Protein FBXW7; PFTK1; CDK13; CDKN1A; CDK12; CDK4; CDK6; USP2; PTCH1; CDK14
Function enzyme binding
Related Protein THRB; DAXX; EHHADH; KDM1A; ZFP36; CASP2; KALRN; BACE1; HIST1H2AL; CUTA
Function histone deacetylase activity
Related Protein HDAC9; NACC2; HDAC10; HDAC6; ATXN3L; HDAC4; SIRT1; HDAC2; HDAC7; MTA2
Function histone deacetylase binding
Related Protein HDAC6; NACC2; KPNA2; USF1; ZFP932; RFXANK; SIRT2; HOXA10; MAGEA1; BRMS1LA
Function protein binding
Related Protein RGS6; PAGE5; SP140; USP37; C2orf51; HEMGN; LINGO1; LRP1; PAAF1; MAGEA8
Function protein deacetylase activity
Related Protein SIRT2; HDAC5; SIN3A; HDAC2; HDAC3; SIRT1; HDAC1; HDAC4; HDAC9; HDAC10
Function transcription corepressor activity
Related Protein CCND1; FEV; ID4; ALX1; ZHX3; MYBBP1A; RLIM; AEBP2; NSD1; RCOR2
Function transcription factor binding
Related Protein RPS3; CCND1; TRP53; FOXC1; PSMC5; Ar; LCOR; NLK; TAF1; TBX5

Interacting Protein

HDAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC3.
NCOR2; NCOR1; KDM1A; L3MBTL2; MAGEA2

HDAC3 Related Articles

Svegliati, S; Marrone, G; et al. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. SCIENCE SIGNALING 7:-(2014).
Hoeksema, MA; Gijbels, MJJ; et al. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO MOLECULAR MEDICINE 6:1124-1132(2014).