Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

HDAC6

  • Official Full Name

    histone deacetylase 6

  • Overview

    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
  • Synonyms

    HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • FLAG
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HDAC6-401H Active Recombinant Human Histone Deacetylase 6, His-tagged Insect Cell His
Human HDAC6-1359H Active Recombinant Human HDAC6, GST-tagged Sf9 Insect Cell GST Full length
Human HDAC6-397H Active Recombinant Human Histone Deacetylase 6, GST-tagged Insect Cell GST
Human HDAC6-405H Active Recombinant Human HDAC6, GST-tagged Sf9 Insect Cell GST
Human HDAC6-28922TH Recombinant Human HDAC6 N/A
Human HDAC6-4648H Recombinant Human HDAC6 Protein, GST-tagged Wheat Germ GST
Human HDAC6-399H Recombinant Human Histone Deacetylase 6, GST-tagged Wheat Germ GST
Human HDAC6-398H Recombinant Human Histone Deacetylase 6, FLAG-tagged E.coli Flag
Human HDAC6-400H Recombinant Human HDAC6 protein, FLAG-tagged Insect Cell FLAG
Human HDAC6-402H Recombinant Human Histone Deacetylase 6, GST-tagged E.coli GST
Human HDAC6-97H Recombinant Human HDAC6 Protein, GST-tagged Insect Cell GST 1-1215
Human HDAC6-131H Recombinant Human HDAC6 protein, His-tagged E.coli His Val166~Leu348
Human HDAC6-132H Recombinant Human HDAC6 protein, His-tagged E.coli His Gln1038~Gln1204
Human HDAC6-5603HCL Recombinant Human HDAC6 293 Cell Lysate HEK293 N/A
Human HDAC6-313H Active Recombinant Human HDAC6 Protein HEK293 cells N/A amino acids 2–1215
Human HDAC6-41H Recombinant Human HDAC6 Protein, GST-tagged Insect Cell GST
Human HDAC6-255HFL Recombinant Full Length Human HDAC6 Protein, C-Flag-tagged Mammalian cells Flag
Human HDAC6-096H Recombinant Human HDAC6 Protein, GST-tagged Insect cell GST
Human HDAC6-111H Recombinant Human HDAC6 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human HDAC6422Z Recombinant Human HDAC6 (zebrafish) (440-798) Protein
Human HDAC6-1055H Recombinant Human HDAC6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HDAC6-3025H Recombinant Human HDAC6 protein, His-SUMO-tagged E.coli His-SUMO 1-488aa
Human HDAC6-2236H Recombinant Human HDAC6 Protein, His-tagged E.coli N-His Ser479-Arg835
Human HDAC6-3026H Recombinant Human HDAC6 protein, His-tagged E.coli His 489-840aa
Human HDAC6-1055H-B Recombinant Human HDAC6 Protein Pre-coupled Magnetic Beads HEK293
Human HDAC6-3408H Recombinant Human HDAC6 Protein (Met1-His1215), C-His tagged Mammalian cells C-His Met1-His1215
Human HDAC6-3409H Recombinant Human HDAC6 Protein (Full Length), C-His tagged E.coli C-His Full Length
Human HDAC6-3410H Recombinant Human HDAC6 Protein (Ser479-Arg835), His tagged E.coli His Ser479-Arg835
Mouse Hdac6-1370M Recombinant Mouse Hdac6 protein, His & T7-tagged E.coli His/T7 Arg560~Pro811 (Accession # Q9Z2V5)
Mouse HDAC6-7533M Recombinant Mouse HDAC6 Protein Mammalian Cell His
Mouse Hdac6-1104M Recombinant Mouse Hdac6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HDAC6-4092M-B Recombinant Mouse HDAC6 Protein Pre-coupled Magnetic Beads HEK293
Mouse HDAC6-4092M Recombinant Mouse HDAC6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hdac6-1371R Recombinant Rat Hdac6 protein, His & T7-tagged E.coli His/T7 Gly565~Pro813 (Accession # F1LSE3)
Rhesus Macaque HDAC6-2056R Recombinant Rhesus monkey HDAC6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HDAC6-1877R-B Recombinant Rhesus Macaque HDAC6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HDAC6-1877R Recombinant Rhesus Macaque HDAC6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig HDAC6-958P Recombinant Pig HDAC6 Protein, His-tagged E.coli N-His Asp751-Arg1130
Kit-1742 HDAC6 Fluorogenic Assay Kit N/A
Kit-1028 HDAC6 Activity Assay Kit (Fluorometric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HDAC6 Related Articles
  • HDAC6 Related Signal Pathway

HDAC6 involved in several pathways and played different roles in them. We selected most pathways HDAC6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismHIST1H3D;ADORA2A;HIST1H3F;HIST2H2BE;KRAS;HRAS;HIST1H2BM;HIST1H2AP;HDAC4
Assembly of the primary ciliumB9D2;CEP63;OST4;TTC21B;CKAP5;CEP78;NDE1;CSNK1E;PCM1
Cell cycleTGFB3;TBC1D8;GMNN;DYRK1A;NUPL2;CEP164;CENPJ;CDKN2A;MCM6L
Cellular response to heat stressMAPKAPK2B;HSPA7;BAG3;HSPA14;DNAJB6;HSBP1B;PTGES3;RPS19BP1;DNAJC2
Cellular responses to stressDNAJC7;UBN1;EED;CDK6;HIST1H1E;RBBP4;RPS19BP1;TERF2IP;EGLN1B
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsCDK8;HEY1;ADAM10;HEYL;JAG1;CCNC;JAG2;HEY2;MIB1
Constitutive Signaling by NOTCH1 PEST Domain MutantsCDK8;HDAC5;ADAM10;HDAC6;MIB1;JAG2;CCNC;HEY2;HEYL
DiseaseKPNA5;HMGA1;SUPT5H;WHSC2;ANTXR2;OGN;CUX1;MYO18A;HDAC5

HDAC6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.

Function Related Protein
Hsp90 protein bindingHIF1A;ARNTL;HDAC6;FKBP6;GBP1;PACRG;NPAS2;STUB1;PPID
NAD-dependent histone deacetylase activity (H3-K14 specific)HDAC1;HDAC2;HDAC3;HDAC7A;HDAC11;HDAC5;HDAC10;HDAC8;HDAC6
actin bindingRP2;CAMK2B;MYO1C;SPTAN1;ARPC1A;MYBPC1;MYHZ1.2;PFN1;TNS1
alpha-tubulin bindingSPAST;B4GALT1;PPARGC1A;TRPV4;SERPINB1A;BBS4;C9orf24;OFD1;SLC6A2
beta-catenin bindingCHD8;TCF7;AXIN1;PTPRU;SHROOM2;MED12L;AXIN2;BCL9L;SMAD7
beta-tubulin bindingBBS4;CCT5;SLC6A2;VAPB;AKAP1;B4GALT1;SERPINB1A;PIFO;ADNP
core promoter bindingELK4;RBMX;NOTCH1;HDAC2;HDAC4;NONO;MTA1;KDM3A;MYOD1
dynein complex bindingHDAC6;CCDC155;TPR
enzyme bindingTH;PLCE1;PLAUR;HDAC1;KIAA1967;PAWR;KDM1A;PCCA;PICK1
histone deacetylase activityHDAC5;HDAC7;HDAC6;SIRT1;MTA2;HDAC2;HDAC11;HDAC9B;HDAC4
histone deacetylase bindingCEBPB;MAGEA1;TFAP4;KAT2A;FOXP3;SIRT2;RFXANK;HDAC1;SOD3
microtubule bindingKCNH2A;MAP1LC3C;KIF20A;KIF5AA;CAMSAP1A;DYNC1I1;TRIM54;KIF25;KLC3
misfolded protein bindingEDEM1;DNAJC3;SDF2L1;STUB1;DNAJB9;F12;DNAJC10;TOR1A;HSPD1
polyubiquitin bindingHDAC6;DZIP3;BAG6;BRCC3;SHARPIN;BRE;TNIP3;TNIP2;PSMD4B
protein bindingMS4A12;GPR37L1;SSNA1;SPRR2A;CHRM3;PDE6H;RSU1;POT1;MON2
tau protein bindingSERPINB1A;HDAC6;S100B;SNCA;FKBP4;AATF;BIN1;DYRK1A;PPP2R2A
tubulin deacetylase activityHDAC6;SIRT2
ubiquitin protein ligase bindingCDKN1A;IKBKE;TMBIM6;XRCC5;SCN5A;UBXN1;OTUB1;RNF40;LRPPRC
zinc ion bindingEP300;CTCF;ZBBX;RC3H2;SOLH;PML;CAR1;RNF125;LHX4

HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.

EGFR; UBC; CYLD; ADRBK1

Bobrowicz, M; Dwojak, M; et al. HDAC6 INHIBITION AUGMENTS THE EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES BY UP-REGULATING CD20 LEVEL IN MALIGNANT B-CELLS. HAEMATOLOGICA 99:437-437(2014).
Noack, M; Leyk, J; et al. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. GLIA 62:535-547(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can HDAC6 inhibitors be used in combination with other therapies, and if so, what synergistic effects are expected? 06/19/2022

Yes, HDAC6 inhibitors can be combined with other therapies for enhanced efficacy. Synergistic effects may include improved anti-cancer activity or neuroprotection.

Are there any ongoing clinical trials targeting HDAC6, and if so, what are the potential outcomes for patients? 05/29/2020

Yes, there are clinical trials exploring HDAC6 inhibitors as potential treatments. Positive outcomes could lead to new therapeutic options for patients.

In what other diseases has HDAC6 been implicated, and how might this knowledge be applied clinically? 12/24/2018

HDAC6 is implicated in neurodegenerative diseases and inflammatory disorders. Understanding its role could lead to novel therapeutic approaches for these conditions.

How does HDAC6 influence cellular processes, and why is this relevant in a clinical setting? 12/13/2017

HDAC6 regulates cell motility, protein trafficking, and other processes. Understanding these mechanisms is crucial for developing targeted therapies in various diseases.

Are there any known genetic variations in HDAC6, and how might these impact individual responses to treatments in a clinical setting? 08/22/2016

Genetic variations in HDAC6 may influence individual responses to treatments. Personalized medicine approaches could consider these variations for better outcomes.

Customer Reviews (3)

Write a review
Reviews
06/23/2019

    Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

    12/07/2018

      The bands of proteins in Western Blotting experiments were very clear.

      09/16/2018

        Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

        Ask a Question for All HDAC6 Products

        Required fields are marked with *

        My Review for All HDAC6 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends