HDAC6

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HDAC6

Official Full Name histone deacetylase 6
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Synonyms HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC6-313H Recombinant Human HDAC6 Protein HEK293 cells N/A
    Mouse Hdac6-1104M Recombinant Mouse Hdac6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HDAC6-111H Recombinant Human HDAC6 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human HDAC6-41H Recombinant Human HDAC6 Protein, GST-tagged Insect Cell GST
    Human HDAC6-131H Recombinant Human HDAC6 protein, His-tagged E.coli His
    Human HDAC6-132H Recombinant Human HDAC6 protein, His-tagged E.coli His
    Human HDAC6-1359H Recombinant Human HDAC6 (Active), GST-tagged Sf9 Insect Cell GST
    Human HDAC6-28922TH Recombinant Human HDAC6 N/A
    Human HDAC6-397H Recombinant Human Histone Deacetylase 6, GST-tagged Insect Cell GST
    Human HDAC6-398H Recombinant Human Histone Deacetylase 6, FLAG-tagged E.coli Flag
    Human HDAC6-399H Recombinant Human Histone Deacetylase 6, GST-tagged Wheat Germ GST
    Human HDAC6-400H Recombinant Human Histone Deacetylase 6, FLAG-tagged Insect Cell Flag
    Human HDAC6-401H Recombinant Human Histone Deacetylase 6, His-tagged Insect Cell His
    Human HDAC6-402H Recombinant Human Histone Deacetylase 6, GST-tagged E.coli GST
    Human HDAC6-405H Recombinant Human HDAC6, GST-tagged Sf9 Insect Cell GST
    Human HDAC6-4648H Recombinant Human HDAC6 Protein, GST-tagged Wheat Germ GST
    Human HDAC6-5603HCL Recombinant Human HDAC6 293 Cell Lysate HEK293 N/A
    Human HDAC6-97H Recombinant Human HDAC6 Protein, GST-tagged Insect Cell GST
    Mouse Hdac6-1370M Recombinant Mouse Hdac6 protein, His & T7-tagged E.coli His/T7
    Mouse HDAC6-7533M Recombinant Mouse HDAC6 Protein Mammalian Cell His
    Rat Hdac6-1371R Recombinant Rat Hdac6 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque HDAC6-2056R Recombinant Rhesus monkey HDAC6 Protein, His-tagged Mammalian Cell His
    Kit-1028 HDAC6 Activity Assay Kit (Fluorometric) N/A
    Kit-1742 HDAC6 Fluorogenic Assay Kit N/A

    HDAC6 involved in several pathways and played different roles in them. We selected most pathways HDAC6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alcoholism HIST1H2AG; HDAC2; SLC29A1; GNB5; HIST1H3H; HIST1H2AB; HIST1H4D; PRKACA; CREB3L1; HIST3H2BB
    Assembly of the primary cilium CC2D2A; NEDD1; TCTEX1D2; BBS1; CEP290; DCTN1; CP110; OFD1; PKD2; B9D1
    Cell cycle OFD1; GADD45G; SMC1B; CEP290; RAD17; CDKN2B; ANAPC11; NEK9; SSNA1; NEK2
    Cellular response to heat stress DNAJC2; DNAJC7; RPS19BP1; HSPA14; BAG3; MAPKAPK2B; EEF1A1; DNAJB6; HSPA12B; PTGES3
    Cellular responses to stress ERF; WDR45; TXNRD2; BMI1A; HIRA; HIF1AL; SUZ12; TXN; TERF2; CHMP4B
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HEY1; MIB1; ADAM10; HEY2; JAG1; HEYL; CDK8; JAG2; HDAC6; CCNC
    Constitutive Signaling by NOTCH1 PEST Domain Mutants CDK8; ADAM10; JAG2; HEY1; HEYL; HDAC6; MIB1; JAG1; HDAC5; CCNC
    Disease CCNC; APOBEC3G; CYP11A1; gag; RPL35; FDXR; RLBP1; FMOD; TTR; HDAC6

    HDAC6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.

    Function Related Protein
    Hsp90 protein binding AHR; NPAS2; ERN1; EIF2AK3; GBP1; TELO2; UNC45B; CDC37; PACRG; STUB1
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC8; HDAC6; HDAC10; HDAC4; HDAC2; HDAC9; HDAC7; HDAC3; HDAC5; HDAC7A
    actin binding WASL; C19orf21; TNNT2A; PLEC; LMOD2; DMTN; ARPC5L; HIP1RB; PARK2; IPP
    alpha-tubulin binding CAV3; PROL1; FNTA; SPAST; RACGAP1; SLC6A2; HDAC6; BBS4; SERPINB1A; ARL4C
    beta-catenin binding RORA; GRIP1; NF2; PXN; AXIN1; PSEN1; TRPC4; CTNNA1; LZTS2A; CDH24
    beta-tubulin binding TBCD; HDAC6; SPAST; GABARAP; CASC1; VAPB; RACGAP1; ADNP; EMD; IFT74
    core promoter binding MTF1; PSPC1; IFI16; NPAS2; NKX3; XBP1; RB1; NONO; CCAR1; SPI1
    dynein complex binding CCDC155; TPR; HDAC6
    enzyme binding SCNM1; KPNB1; CASP2; Ar; PRKCE; MSH3; HIST1H2AD; UGT1A1; MARCH6; GNB2L1
    histone deacetylase activity NACC2; ATXN3L; HDAC8; HDAC9B; HDAC3; HDAC1; HDAC5; HDAC2; MTA2; HDAC11
    histone deacetylase binding XBP1; YWHAB; ZNF703; BRMS1LA; NR2E1; RELA; KPNA2; WDTC1; SIX3; SOD3
    microtubule binding MAP6D1; CHD4; NDE1; CLIP3; KIF9; MID2; WDR43; S100A9; KIF5B; FMN1
    misfolded protein binding BAG6; DNAJC3; HSPA5; STUB1; HDAC6; DNAJC10; F12; HSPD1; DNAJB9; EDEM1
    polyubiquitin binding TNIP2; RAD23A; AGL; BAG6; BRE; HDAC6; RAD18; PSMD4A; EPS15; RAD23B
    protein binding GCC2; RAD51C; WRAP53; C1orf116; LRCH4; GRIA2; MARCH5; CRBN; HEMGN; ATPAF2
    tau protein binding BIN1; AATF; DYRK1A; PPP2R2A; HDAC6; SERPINB1A; SNCA; FKBP4; APOE; S100B
    tubulin deacetylase activity HDAC6; SIRT2
    ubiquitin protein ligase binding NEDD8; SNCAIP; FLJ11011L; TMBIM6; TRAF6; GLMN; PINK1; UBE2J1; OTUB1; BLZF1
    zinc ion binding DDX58; ZDHHC20; ZFAND6; DDX41; SCEL; SEC24D; MICALL2; AGTPBP1; ZFHX3; CSRP1A

    HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.

    EGFR; UBC; CYLD; ADRBK1

    Bobrowicz, M; Dwojak, M; et al. HDAC6 INHIBITION AUGMENTS THE EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES BY UP-REGULATING CD20 LEVEL IN MALIGNANT B-CELLS. HAEMATOLOGICA 99:437-437(2014).
    Noack, M; Leyk, J; et al. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. GLIA 62:535-547(2014).

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