hdac6
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  • Official Full Name
  • histone deacetylase 6
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;
Cat.#:HDAC6-313HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HDAC6 Protein
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Cat.#:HDAC6-4648HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
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Cat.#:HDAC6-398HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
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Cat.#:HDAC6-399HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-400HTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
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Cat.#:HDAC6-401HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, His-tagged
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Cat.#:HDAC6-402HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-131HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
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Cat.#:HDAC6-132HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
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Cat.#:HDAC6-28922THTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC6
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Cat.#:HDAC6-397HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-405HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6, GST-tagged
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Cat.#:HDAC6-97HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
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Cat.#:Hdac6-1370MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hdac6 protein, His & T7-tagged
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Cat.#:HDAC6-7533MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC6 Protein
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Cat.#:Hdac6-1371RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hdac6 protein, His & T7-tagged
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Cat.#:HDAC6-2056RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC6 Protein, His-tagged
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Cat.#:HDAC6-1359HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6 (Active), GST-tagged
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Cat.#:HDAC6-5603HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC6 293 Cell Lysate
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Cat.#:Kit-1028Tag:
Source (Host):Species:
Product nameHDAC6 Activity Assay Kit (Fluorometric)
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Cat.#:Kit-1742Tag:
Source (Host):Species:
Product nameHDAC6 Fluorogenic Assay Kit
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Involved Pathway

HDAC6 involved in several pathways and played different roles in them. We selected most pathways HDAC6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST1H2BE; GRIN3A; GNB1; GRIN2D; SLC18A1; GNG5; HIST2H2BB; HAT1; KRAS; GM14479
Assembly of the primary cilium
CLASP1A; BBS13; TCTN3; WDR19; TTBK2; CCP110; CLUAP1; PROL1; EXOC3; BBS10
Cell cycle
CDC45; FKBP6; CDC14A; CUL1A; CENPO; KIF20A; HDAC6; CLASP1A; ORC5; CDC20
Cellular response to heat stress
NUP50; DNAJB6; DNAJC2; HSPH1; HSBP1A; HSPA13; HSPA12B; RPS19BP1; NUPL2; NUP35
Cellular responses to stress
HTATIP; CDKN2C; POT1A; MAP1LC3B; NUP35; DNAJB6; PTGES3; ATG101; TERF2; EPAS1B
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HEY1; CCNC; HEYL; HDAC6; CDK8; HEY2; JAG2; JAG1; HDAC5; ADAM10
Constitutive Signaling by NOTCH1 PEST Domain Mutants
HEY2; CDK8; HDAC5; HEYL; JAG1; HEY1; JAG2; ADAM10; MIB1; CCNC
Disease
ARF1; RPL35; KPNA4; ANTXR2; ACAN; EPM2A; GYG1; AP2M1; MIB1; GYG2

Protein Function

HDAC6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.
Function
Related Protein
Function Hsp90 protein binding
Related Protein GBP1; NPAS2; AHR; USP19; RPS3; CDC37; NASP; EIF2AK3; TELO2; HIF1A
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC2; HDAC8; HDAC3; HDAC11; HDAC9B; HDAC1; HDAC4; HDAC7A; HDAC5; HDAC9
Function actin binding
Related Protein CFL2L; PHACTR4B; LCP1; MTSS1L; NRAP; MYH9A; TAGLN; ABRA; TNS1; PLEC
Function alpha-tubulin binding
Related Protein PACRG; RACGAP1; WASH; NDEL1; SNCA; B4GALT1; WASH1; SERPINB1A; ARL4C; INO80
Function beta-catenin binding
Related Protein BCL9L; RORA; CDH24; SMAD3; TBL1X; SHROOM2; SALL1; APC2; TCF7L1B; CDH2
Function beta-tubulin binding
Related Protein RANBP10; GABARAPL2; GABARAPL1; NDEL1; MAP1S; RACGAP1; SPAST; TRPV4; RGS2; SLC6A2
Function core promoter binding
Related Protein E2F8; NPAS2; E2F7; MYBBP1A; E2F2; EZH2; SFPI1; NKX3; DHX36; HNRNPU
Function dynein complex binding
Related Protein CCDC155; HDAC6; TPR
Function enzyme binding
Related Protein PCBP2; ATG3; EGLN1; HMGA1-RS1; P4HB; LDB1; HAND2; POR; PHKG2; PLCE1
Function histone deacetylase activity
Related Protein ATXN3L; SIRT2; HDAC2; NACC2; HDAC8; HDAC5; HDAC1; HDAC3; HDAC10; MTA2
Function histone deacetylase binding
Related Protein HIST1H1B; HDAC10; KPNA2; GMNN; SP1; RELA; XBP1; MAPK8; CCND1; CEBPA
Function microtubule binding
Related Protein MARK4; KIF4A; FAM154A; PPP5C; NME8; MAST2; TPPP; GABARAPA; MAPRE1B; KIF23
Function misfolded protein binding
Related Protein HSPD1; DNAJC3; BAG6; EDEM1; F12; CLU; TOR1A; SDF2L1; HSPA5; DNAJB9
Function polyubiquitin binding
Related Protein PSMD4B; VCP; FAM175A; EPS15; BAG6; AGL; TNIP2; HDAC6; ZFAND6; BRE
Function protein binding
Related Protein WDR74; SLMAP; RABAC1; NIPBL; MALL; EMILIN1; RFX4; LIN9; EIF3M; FIS1
Function tau protein binding
Related Protein PPP2R2A; HDAC6; SERPINB1A; FKBP4; SNCA; S100B; BIN1; AATF; DYRK1A; APOE
Function tubulin deacetylase activity
Related Protein HDAC6; SIRT2
Function ubiquitin protein ligase binding
Related Protein XBP1; CALR; TSG101; MAGEA2; BAG5; VCP; FZD6; CUL9; RNF20; CUL1
Function zinc ion binding
Related Protein ARHGEF2; RBM4.1; ZZEF1; LIMS3; KDM4A; TRAF4A; HNF4G; ZSWIM3; SAMHD1; ESR2

Interacting Protein

HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.
EGFR; UBC; CYLD; ADRBK1

HDAC6 Related Articles

Bobrowicz, M; Dwojak, M; et al. HDAC6 INHIBITION AUGMENTS THE EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES BY UP-REGULATING CD20 LEVEL IN MALIGNANT B-CELLS. HAEMATOLOGICA 99:437-437(2014).
Noack, M; Leyk, J; et al. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. GLIA 62:535-547(2014).