HDAC6
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Official Full Name
histone deacetylase 6
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Overview
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008] -
Synonyms
HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- Insect cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- Myc
- DDK
- Flag
- FLAG
- GST
- His (Fc)
- Avi
- His|T7
- SUMO
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- HDAC6 Related Articles
- HDAC6 Related Signal Pathway
HDAC6 involved in several pathways and played different roles in them. We selected most pathways HDAC6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alcoholism | HIST1H3D;ADORA2A;HIST1H3F;HIST2H2BE;KRAS;HRAS;HIST1H2BM;HIST1H2AP;HDAC4 |
Assembly of the primary cilium | B9D2;CEP63;OST4;TTC21B;CKAP5;CEP78;NDE1;CSNK1E;PCM1 |
Cell cycle | TGFB3;TBC1D8;GMNN;DYRK1A;NUPL2;CEP164;CENPJ;CDKN2A;MCM6L |
Cellular response to heat stress | MAPKAPK2B;HSPA7;BAG3;HSPA14;DNAJB6;HSBP1B;PTGES3;RPS19BP1;DNAJC2 |
Cellular responses to stress | DNAJC7;UBN1;EED;CDK6;HIST1H1E;RBBP4;RPS19BP1;TERF2IP;EGLN1B |
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | CDK8;HEY1;ADAM10;HEYL;JAG1;CCNC;JAG2;HEY2;MIB1 |
Constitutive Signaling by NOTCH1 PEST Domain Mutants | CDK8;HDAC5;ADAM10;HDAC6;MIB1;JAG2;CCNC;HEY2;HEYL |
Disease | KPNA5;HMGA1;SUPT5H;WHSC2;ANTXR2;OGN;CUX1;MYO18A;HDAC5 |
HDAC6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.
Function | Related Protein |
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Hsp90 protein binding | HIF1A;ARNTL;HDAC6;FKBP6;GBP1;PACRG;NPAS2;STUB1;PPID |
NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC1;HDAC2;HDAC3;HDAC7A;HDAC11;HDAC5;HDAC10;HDAC8;HDAC6 |
actin binding | RP2;CAMK2B;MYO1C;SPTAN1;ARPC1A;MYBPC1;MYHZ1.2;PFN1;TNS1 |
alpha-tubulin binding | SPAST;B4GALT1;PPARGC1A;TRPV4;SERPINB1A;BBS4;C9orf24;OFD1;SLC6A2 |
beta-catenin binding | CHD8;TCF7;AXIN1;PTPRU;SHROOM2;MED12L;AXIN2;BCL9L;SMAD7 |
beta-tubulin binding | BBS4;CCT5;SLC6A2;VAPB;AKAP1;B4GALT1;SERPINB1A;PIFO;ADNP |
core promoter binding | ELK4;RBMX;NOTCH1;HDAC2;HDAC4;NONO;MTA1;KDM3A;MYOD1 |
dynein complex binding | HDAC6;CCDC155;TPR |
enzyme binding | TH;PLCE1;PLAUR;HDAC1;KIAA1967;PAWR;KDM1A;PCCA;PICK1 |
histone deacetylase activity | HDAC5;HDAC7;HDAC6;SIRT1;MTA2;HDAC2;HDAC11;HDAC9B;HDAC4 |
histone deacetylase binding | CEBPB;MAGEA1;TFAP4;KAT2A;FOXP3;SIRT2;RFXANK;HDAC1;SOD3 |
microtubule binding | KCNH2A;MAP1LC3C;KIF20A;KIF5AA;CAMSAP1A;DYNC1I1;TRIM54;KIF25;KLC3 |
misfolded protein binding | EDEM1;DNAJC3;SDF2L1;STUB1;DNAJB9;F12;DNAJC10;TOR1A;HSPD1 |
polyubiquitin binding | HDAC6;DZIP3;BAG6;BRCC3;SHARPIN;BRE;TNIP3;TNIP2;PSMD4B |
protein binding | MS4A12;GPR37L1;SSNA1;SPRR2A;CHRM3;PDE6H;RSU1;POT1;MON2 |
tau protein binding | SERPINB1A;HDAC6;S100B;SNCA;FKBP4;AATF;BIN1;DYRK1A;PPP2R2A |
tubulin deacetylase activity | HDAC6;SIRT2 |
ubiquitin protein ligase binding | CDKN1A;IKBKE;TMBIM6;XRCC5;SCN5A;UBXN1;OTUB1;RNF40;LRPPRC |
zinc ion binding | EP300;CTCF;ZBBX;RC3H2;SOLH;PML;CAR1;RNF125;LHX4 |
HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.
EGFR; UBC; CYLD; ADRBK1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, HDAC6 inhibitors can be combined with other therapies for enhanced efficacy. Synergistic effects may include improved anti-cancer activity or neuroprotection.
Yes, there are clinical trials exploring HDAC6 inhibitors as potential treatments. Positive outcomes could lead to new therapeutic options for patients.
HDAC6 is implicated in neurodegenerative diseases and inflammatory disorders. Understanding its role could lead to novel therapeutic approaches for these conditions.
HDAC6 regulates cell motility, protein trafficking, and other processes. Understanding these mechanisms is crucial for developing targeted therapies in various diseases.
Genetic variations in HDAC6 may influence individual responses to treatments. Personalized medicine approaches could consider these variations for better outcomes.
Customer Reviews (3)
Write a reviewTheir expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.
The bands of proteins in Western Blotting experiments were very clear.
Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.
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