hdac6
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  • Official Full Name
  • histone deacetylase 6
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;
Cat.#:HDAC6-313HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HDAC6 Protein
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Cat.#:HDAC6-4648HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
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Cat.#:HDAC6-398HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
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Cat.#:HDAC6-399HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-400HTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
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Cat.#:HDAC6-401HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, His-tagged
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Cat.#:HDAC6-402HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-131HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
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Cat.#:HDAC6-132HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
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Cat.#:HDAC6-28922THTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC6
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Cat.#:HDAC6-397HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-405HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6, GST-tagged
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Cat.#:HDAC6-97HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
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Cat.#:Hdac6-1370MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hdac6 protein, His & T7-tagged
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Cat.#:HDAC6-7533MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC6 Protein
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Cat.#:Hdac6-1371RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hdac6 protein, His & T7-tagged
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Cat.#:HDAC6-2056RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC6 Protein, His-tagged
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Cat.#:HDAC6-1359HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6 (Active), GST-tagged
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Cat.#:HDAC6-5603HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC6 293 Cell Lysate
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Cat.#:Kit-1028Tag:
Source (Host):Species:
Product nameHDAC6 Activity Assay Kit (Fluorometric)
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Cat.#:Kit-1742Tag:
Source (Host):Species:
Product nameHDAC6 Fluorogenic Assay Kit
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Involved Pathway

HDAC6 involved in several pathways and played different roles in them. We selected most pathways HDAC6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST1H4M; HIST2H2BB; CREB3L1; GNB4; CAMKK2; SHC2; HIST1H2AN; HIST2H4A; GRIN2C; HDAC8
Assembly of the primary cilium
IFT80; ARF4; CETN2; MAPRE1A; KIF3CB; MKS1; B9D2; KIFAP3; MAPRE1B; CEP76
Cell cycle
TCTN2; MYCA; ZBTB17; ITGB3BP; RAD9; PLK4; KAT5; RAD21A; CLSPN; MCM3L
Cellular response to heat stress
NUP35; DPF1; C11orf73; BAG5; EEF1A1; HSBP1; PTGES3; HSPH1; HSPA12B; KIAA1967
Cellular responses to stress
DYNLL2; EHMT2; CBX8A; CABIN1; DNAJB6; HMGA1B; DNAJC2; RPS19BP1; HIST1H1B; CBX6A
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
ADAM10; HEYL; HEY2; HDAC6; CDK8; JAG1; HDAC5; JAG2; HEY1; CCNC
Constitutive Signaling by NOTCH1 PEST Domain Mutants
MIB1; JAG2; HDAC5; HEY1; ADAM10; CDK8; HEY2; JAG1; CCNC; HEYL
Disease
ARF1; KPNA4; OPN1LW; TLR10; CFTR; CTBP1; MMADHC; SFTPB; ANTXR1; RCC1

Protein Function

HDAC6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.
Function
Related Protein
Function Hsp90 protein binding
Related Protein ARNTL; AHR; STUB1; UNC45B; EIF2AK3; CHORDC1; TELO2; HDAC6; NASP; HIF1A
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC7; HDAC4; HDAC8; HDAC10; HDAC1; HDAC2; HDAC11; HDAC9B; HDAC3; HDAC7A
Function actin binding
Related Protein ITGB1; EVL; CAPGB; FMNL2; WASF2; CNN1; MACF1; WASH; NF2B; SHROOM4
Function alpha-tubulin binding
Related Protein PPARGC1A; ARL4C; ARL8B; SPAST; FNTA; SERPINB1A; FAM110C; OFD1; PROL1; HDAC6
Function beta-catenin binding
Related Protein ESR1; PTPRK; CTNNA3; PSEN1; PXN; TCF7; SLC9A3R2; LEF1; CDH2; APC2
Function beta-tubulin binding
Related Protein PROL1; SERPINB1A; IFT74; BBS4; ARL8B; PDCD5; SNCA; GABARAPL2; UXT; PIFO
Function core promoter binding
Related Protein KLF4; SFPQ; HDAC6; E2F1; EP300; SAFB; IFI16; IRF9; FOXP3; RELB
Function dynein complex binding
Related Protein HDAC6; TPR; CCDC155
Function enzyme binding
Related Protein ARRB2; PPP3CB; CBX1; Alb; CREB1; TAF10; RPS3; YWHAH; MDM2; POLB
Function histone deacetylase activity
Related Protein NACC2; HDAC7; HDAC5; SIRT1; HDAC8; HDAC2; HDAC9; HDAC6; ATXN3L; MTA2
Function histone deacetylase binding
Related Protein ANKRA2; MEF2B; SP2; CEBPA; CBX5; HOXA10; NKX3; MAGEA2; YY1; RAD9
Function microtubule binding
Related Protein PRNP; SERPINB1A; JAKMIP2; FMR1; MTAP7D3; SGIP1; EML1; KIF5A; MAP1LC3C; MAPRE3B
Function misfolded protein binding
Related Protein CLU; DNAJB9; HSPA5; HSPD1; TOR1A; SDF2L1; F12; EDEM1; DNAJC3; HDAC6
Function polyubiquitin binding
Related Protein DNAJB2; PSMD4B; UBXN1; TNIP3; TNIP2; BAG6; DZIP3; THRSP; FAM175A; UBQLN4
Function protein binding
Related Protein SEMA7A; FBXO27; EVL; RAD17; RBM12B; CDKN1A; BET1; ARPC4; MVP; MDM2
Function tau protein binding
Related Protein SNCA; S100B; SERPINB1A; APOE; PPP2R2A; AATF; HDAC6; DYRK1A; BIN1; FKBP4
Function tubulin deacetylase activity
Related Protein HDAC6; SIRT2
Function ubiquitin protein ligase binding
Related Protein MOAP1; UQCRC1; NPLOC4; HSPA5; ANKRD32; CXCR4; DERL1; FAF1; ABI2; VCP
Function zinc ion binding
Related Protein ZCCHC16; LMX1A; ZNF146; RP9; P2RX1; SIAH1; TRIM8A; RNF213; TRAF3; SLU7

Interacting Protein

HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.
EGFR; UBC; CYLD; ADRBK1

HDAC6 Related Articles

Bobrowicz, M; Dwojak, M; et al. HDAC6 INHIBITION AUGMENTS THE EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES BY UP-REGULATING CD20 LEVEL IN MALIGNANT B-CELLS. HAEMATOLOGICA 99:437-437(2014).
Noack, M; Leyk, J; et al. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. GLIA 62:535-547(2014).