hdac6
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  • Official Full Name
  • histone deacetylase 6
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC6; histone deacetylase 6; HD6; JM21; CPBHM;
Cat.#:HDAC6-313HTag:N/A
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HDAC6 Protein
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Cat.#:HDAC6-4648HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
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Cat.#:HDAC6-398HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
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Cat.#:HDAC6-399HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-400HTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, FLAG-tagged
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Cat.#:HDAC6-401HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, His-tagged
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Cat.#:HDAC6-402HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-131HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
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Cat.#:HDAC6-132HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC6 protein, His-tagged
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Cat.#:HDAC6-28922THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HDAC6
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Cat.#:HDAC6-397HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 6, GST-tagged
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Cat.#:HDAC6-405HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6, GST-tagged
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Cat.#:HDAC6-97HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC6 Protein, GST-tagged
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Cat.#:Hdac6-1370MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hdac6 protein, His & T7-tagged
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Cat.#:HDAC6-7533MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC6 Protein
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Cat.#:Hdac6-1371RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hdac6 protein, His & T7-tagged
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Cat.#:HDAC6-2056RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC6 Protein, His-tagged
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Cat.#:HDAC6-1359HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC6 (Active), GST-tagged
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Cat.#:HDAC6-5603HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HDAC6 293 Cell Lysate
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Cat.#:Kit-1028Tag:N/A
Source (Host):Species:
Product nameHDAC6 Activity Assay Kit (Fluorometric)
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Cat.#:Kit-1742Tag:N/A
Source (Host):Species:
Product nameHDAC6 Fluorogenic Assay Kit
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Involved Pathway

HDAC6 involved in several pathways and played different roles in them. We selected most pathways HDAC6 participated on our site, such as Alcoholism, Assembly of the primary cilium, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST1H4M; HDAC6; CALM3; DRD1; GRIN3A; ADORA2A; GNG13; FOSB; GNGT2; HIST1H2BF
Assembly of the primary cilium
BBS1; DCTN2; RABL5; BBS5; IFT20; CLUAP1; IFT43; CCT5; FBF1; PROL1
Cell cycle
NUDC; NEK6; BARD1; CTDNEP1A; NUP50; HUS1; RANGAP1B; KIF2C; CLIP1; MSH5
Cellular response to heat stress
DNAJB6; KIAA1967; HSPH1; EEF1A1; NUPL2; NUP35; HSPA13; NUP50; HSPA12B; BAG3
Cellular responses to stress
TXN2; KAT5; POT1A; ST13; AMBRA1; MINK1; HSBP1B; NUP35; RRAGA; DYNLL2
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
ADAM10; HDAC5; CDK8; JAG1; HEYL; HEY2; MIB1; JAG2; CCNC; HDAC6
Constitutive Signaling by NOTCH1 PEST Domain Mutants
CCNC; HDAC6; HEYL; ADAM10; HEY1; HDAC5; JAG1; JAG2; CDK8; HEY2
Disease
TLR6; CPSF6; gag; MYO18A; AP1B1; VPS37A; CCR5; CPSF4; SFTPB; OPN1MW

Protein Function

HDAC6 has several biochemical functions, for example, Hsp90 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC6 itself. We selected most functions HDAC6 had, and list some proteins which have the same functions with HDAC6. You can find most of the proteins on our site.
Function
Related Protein
Function Hsp90 protein binding
Related Protein CSNK2A1; ERBB2; RPS3; FKBP6; EIF2AK3; UNC45A; UNC45B; AHR; GBP1; NASP
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC7; HDAC10; HDAC5; HDAC7A; HDAC9; HDAC3; HDAC2; HDAC9B; HDAC8; HDAC1
Function actin binding
Related Protein MYO1F; HOMER2; WASH; EZRB; SHROOM3; DIAP3; MYH10; PARVG; MPRIP; CALD1
Function alpha-tubulin binding
Related Protein ARL4C; HDAC6; NDEL1; WASH; PROL1; FNTA; SLC6A2; SERPINB1A; INO80; OFD1
Function beta-catenin binding
Related Protein TRPC4; TBL1X; CD2AP; AXIN1; SHROOM2; HDAC6; PTPRK; CDH2; LZTS2A; APC
Function beta-tubulin binding
Related Protein SNCA; VAPB; PACRG; LRPPRC; EMD; ADNP; SERPINB1A; TBCD; OST4; CASC1
Function core promoter binding
Related Protein NKX3; HDAC6; E2F1; HDAC1; GATA1; SPI1; EP300; GTF2B; IFI16; IRF9
Function dynein complex binding
Related Protein CCDC155; TPR; HDAC6
Function enzyme binding
Related Protein ESR2; MTA1; CD40; CREB1; ESR1; USF1; LYN; ECM1; ANK1; MAT2B
Function histone deacetylase activity
Related Protein SIRT1; HDAC9; HDAC2; HDAC6; HDAC3; SIRT2; HDAC7; HDAC4; HDAC11; HDAC9B
Function histone deacetylase binding
Related Protein HDAC1; SOD3; HDAC5; PKN1; HIF1A; HEY2; BCOR; HIST1H1B; SRF; BRMS1
Function microtubule binding
Related Protein CEP350; ARHGEF2; NEIL2; S100A9; REEP1; CASC1; DNM2; REEP4; KIF2B; DPYSL5A
Function misfolded protein binding
Related Protein CLU; DNAJC3; EDEM1; HDAC6; BAG6; SDF2L1; DNAJB9; F12; HSPD1; STUB1
Function polyubiquitin binding
Related Protein FAM175B; EPS15; DZIP3; SHARPIN; UBQLN1; THRSP; PSMD4; FAM175A; PSMD4A; RAD18
Function protein binding
Related Protein GAD1; HTR1A; ZNF230; BAAT; PCGF2; APOBEC3F; UBQLN2; P2RY6; GRIFIN; MICA
Function tau protein binding
Related Protein HDAC6; PPP2R2A; SNCA; SERPINB1A; DYRK1A; S100B; BIN1; APOE; FKBP4; AATF
Function tubulin deacetylase activity
Related Protein SIRT2; HDAC6
Function ubiquitin protein ligase binding
Related Protein CASP8; ANAPC2; TRAF4; GRIK2; TMEM189; UBE2KB; HSPA1L; UBE2J1; PRKAR2A; PER1
Function zinc ion binding
Related Protein MKRN1; ZSWIM7; LHX8A; NEIL1; SNAI1A; SEC24C; TRIM33; ZNF75D; ZNRF2B; MMP14A

Interacting Protein

HDAC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC6.
EGFR; UBC; CYLD; ADRBK1

HDAC6 Related Articles

Bobrowicz, M; Dwojak, M; et al. HDAC6 INHIBITION AUGMENTS THE EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES BY UP-REGULATING CD20 LEVEL IN MALIGNANT B-CELLS. HAEMATOLOGICA 99:437-437(2014).
Noack, M; Leyk, J; et al. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. GLIA 62:535-547(2014).