Recombinant Human HDAC6 Protein, GST-tagged HDAC6-41H

Recombinant Human HDAC6 Protein, GST-tagged

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Recombinant Human HDAC6 Protein, GST-tagged

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Cat.No. : HDAC6-41H
Product Overview : Recombinant human HDAC6 protein with a N-terminal GST-tag was expressed in Sf21 cells.
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Source : Insect cells
Species : Human
Tag : GST
Molecular Mass : 159 kDa
Purity : ≥65% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/mL BSA, and 20 μM fluorogenic HDAC substrate 3.
Stability : ≥ 6 months
Storage : Store it at -80 centigrade
Storage Buffer : 40 mM Tris-HCl pH8.0, 110mM sodium chloride, with 2.2 mM potassium chloride, 0.04% Tween20, 3mM DTT, and 20% glycerol
SDS-PAGE Analysis of HDAC6 :

Lane 1: MW Markers; Lane 2: HDAC6. Representative gel image shown; actual purity may vary between each batch.

HDAC6 Deacetylase Activity :

Gene Name : HDAC6 histone deacetylase 6 [ Homo sapiens (human) ]
Official Symbol : HDAC6
Synonyms : HDAC6; histone deacetylase 6; HD6; JM21; CPBHM; PPP1R90; histone deacetylase 6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6
Gene ID : 10013
mRNA Refseq : NM_001321226
Protein Refseq : NP_001308155
MIM : 300272
UniProt ID : Q9UBN7

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