| Description : |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
131.2 kDa |
| AA Sequence : |
MTSTGQDSTTTRQRRSRQNPQSPPQ DSSVTSKRNIKKGAVPRSIPNLAEV KKKGKMKKLGQAMEEDLIVGLQGMD LNLEAEALAGTGLVLDEQLNEFHCL WDDSFPEGPERLHAIKEQLIQEGLL DRCVSFQARFAEKEELMLVHSLEYI DLMETTQYMNEGELRVLADTYDSVY LHPNSYSCACLASGSVLRLVDAVLG AEIRNGMAIIRPPGHHAQHSLMDGY CMFNHVAVAARYAQQKHRIRRVLIV DWDVHHGQGTQFTFDQDPSVLYFSI HRYEQGRFWPHLKASNWSTTGFGQG QGYTINVPWNQVGMRDADYIAAFLH VLLPVALEFQPQLVLVAAGFDALQG DPKGEMAATPAGFAQLTHLLMGLAG GKLILSLEGGYNLRALAEGVSASLH TLLGDPCPMLESPGAPCRSAQASVS CALEALEPFWEVLVRSTETVERDNM EEDNVEESEEEGPWEPPVLPILTWP VLQSRTGLVYDQNMMNHCNLWDSHH PEVPQRILRIMCRLEELGLAGRCLT LTPRPATEAELLTCHSAEYVGHLRA TEKMKTRELHRESSNFDSIYICPST FACAQLATGAACRLVEAVLSGEVLN GAAVVRPPGHHAEQDAACGFCFFNS VAVAARHAQTISGHALRILIVDWDV HHGNGTQHMFEDDPSVLYVSLHRYD HGTFFPMGDEGASSQIGRAAGTGFT VNVAWNGPRMGDADYLAAWHRLVLP IAYEFNPELVLVSAGFDAARGDPLG GCQVSPEGYAHLTHLLMGLASGRII LILEGGYNLTSISESMAACTRSLLG DPPPLLTLPRPPLSGALASITETIQ VHRRYWRSLRVMKVEDREGPSSSKL VTKKAPQPAKPRLAERMTTREKKVL EAGMGKVTSASFGEESTPGQTNSET AVVALTQDQPSEAATGGATLAQTIS EAAIGGAMLGQTTSEEAVGGATPDQ TTSEETVGGAILDQTTSEDAVGGAT LGQTTSEEAVGGATLAQTTSEAAME GATLDQTTSEEAPGGTELIQTPLAS STDHQTPPTSPVQGTTPQISPSTLI GSLRTLELGSESQGASESQAPGEEN LLGEAAGGQDMADSMLMQGSRGLTD QAIFYAVTPLPWCPHLVAVCPIPAA GLDVTQPCGDCGTIQENWVCLSCYQ VYCGRYINGHMLQHHGNSGHPLVLS YIDLSAWCYYCQAYVHHQALLDVKD IAHQNKFGEDMPHPHTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
