Recombinant Human HDAC6

• Cat.No.: HDAC6-28922TH
• Product Overview: Recombinant full length protein (Human), N-Terminal Tag.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
• Biological activity: Activity: 50 U/ug. One U =1 pmol/min, Assay condition: 25 mM Tris/Cl,pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 uM Biomol substrate (Catalog number KI177), and 5 ng/ul HDAC6. Incubation condition: 60 min at 30oC.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 50mM Tris HCl, 20mM Glutathione, 138mM Sodium chloride, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.Contains 1 UBP-type zinc finger.

Gene Information

• Gene Name: HDAC6 histone deacetylase 6 [ Homo sapiens ]
• Official Symbol: HDAC6
• Synonyms: HDAC6; histone deacetylase 6; FLJ16239; HD6; JM21; KIAA0901
• Gene ID: 10013
• mRNA Refseq: NM_006044
• Protein Refseq: NP_006035
• MIM: 300272
• Uniprot ID: Q9UBN7
• Chromosome Location: Xp11.23
• Pathway: Cell cycle, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
• Function: Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); actin binding