Active Recombinant Human Histone Deacetylase 6, GST-tagged

• Cat.No.: HDAC6-397H
• Product Overview: Full Length Human HDAC6–Class IIb, 160kD with GST tag.

Specification

• Cat. No.: HDAC6-397H
• Description: Histone deacetylase 6, also known as HDAC6, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
• Source: HDAC6 was cloned from human heart cDNA and expressed in insect cells using a baculoviral expression system.
• Purity: Purified, active enzyme.
• Purification Procedure: Glutathione Column
• Activity: 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
• Stability/Shelf-life: >6 months from date of shipment
• Buffer Composition: 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
• Storage: –80°C

Gene Information

• Gene Name: HDAC6 histone deacetylase 6 [ Homo sapiens ]
• Synonyms: HDAC6; FLJ16239; HD6; JM21; histone deacetylase 6; OTTHUMP00000032398; EC 3.5.1.98; KIAA0901.
• Gene ID: 10013
• mRNA Refseq: NM_006044
• Protein Refseq: NP_006035
• MIM: 300272
• UniProt ID: Q9UBN7
• Chromosome Location: Xp11.23
• Pathway: Gene Expression
• Function: actin binding; histone deacetylase activity; histone deacetylase binding; hydrolase activity; metal ion binding; specific transcriptional repressor activity; tubulin deacetylase activity; zinc ion binding

Reviews

06/23/2019

Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

12/07/2018

The bands of proteins in Western Blotting experiments were very clear.

09/16/2018

Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

Q&As

Can HDAC6 inhibitors be used in combination with other therapies, and if so, what synergistic effects are expected?

Yes, HDAC6 inhibitors can be combined with other therapies for enhanced efficacy. Synergistic effects may include improved anti-cancer activity or neuroprotection.

Are there any ongoing clinical trials targeting HDAC6, and if so, what are the potential outcomes for patients?

Yes, there are clinical trials exploring HDAC6 inhibitors as potential treatments. Positive outcomes could lead to new therapeutic options for patients.

In what other diseases has HDAC6 been implicated, and how might this knowledge be applied clinically?

HDAC6 is implicated in neurodegenerative diseases and inflammatory disorders. Understanding its role could lead to novel therapeutic approaches for these conditions.

How does HDAC6 influence cellular processes, and why is this relevant in a clinical setting?

HDAC6 regulates cell motility, protein trafficking, and other processes. Understanding these mechanisms is crucial for developing targeted therapies in various diseases.

Are there any known genetic variations in HDAC6, and how might these impact individual responses to treatments in a clinical setting?

Genetic variations in HDAC6 may influence individual responses to treatments. Personalized medicine approaches could consider these variations for better outcomes.