|Official Full Name||histone deacetylase 7|
|Background||Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]|
|Synonyms||HDAC7; histone deacetylase 7; HD7A; HDAC7A; HD7; histone deacetylase 7A;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
HDAC7 involved in several pathways and played different roles in them. We selected most pathways HDAC7 participated on our site, such as Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Alcoholism||CRH; GRB2; GM14477; CAMKK1; CALM3; HIST3H3; NRAS; HIST1H2BJ; MAOB; HIST1H2BD|
|Viral carcinogenesis||HIST1H2BI; HIST1H4E; YWHAG; PIK3R3; HIST2H4A; PRKACA; PRKACG; GTF2A1L; HIST1H4G; CCND1|
HDAC7 has several biochemical functions, for example, 14-3-3 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC7 itself. We selected most functions HDAC7 had, and list some proteins which have the same functions with HDAC7. You can find most of the proteins on our site.
|14-3-3 protein binding||HDAC7; AANAT; DDIT4; IRS2; PPP1R12A; SRPK2; TSC2; KCNH1; YWHAQ; ZFP36|
|NAD-dependent histone deacetylase activity (H3-K14 specific)||HDAC9; HDAC8; HDAC3; HDAC2; HDAC1; HDAC11; HDAC7A; HDAC7; HDAC4; HDAC9B|
|activating transcription factor binding||GATA4; ZFP516; MEF2D; EP300; PPARG; TAF9; DGKQ; MEF2A; PSIP1; EEF1D|
|chromatin binding||UXT; SMC3; PCGF2; BARX2; LEF1; CDC45; SVEP1; HCFC1; SSRP1; SIN3B|
|histone deacetylase activity||MTA2; HDAC1; HDAC9; HDAC5; SIRT1; HDAC8; HDAC7; HDAC2; HDAC11; SIRT2|
|hydrolase activity||CTSL1B; PPAP2C; Reln; USP43; PPP1CBL; CES1C; MMP1A; TMPRSS11G; RHOT1A; GDPD4|
|metal ion binding||SUCLA2; ADH8B; DPYDB; CTDSPL; ZSWIM7; ZDHHC18; RBAK; ATP2B3A; ZFYVE21; PPM1BA|
|protein binding||CNOT8; UBA1; CTBP1; GDI2; GHR; C4orf19; ACTB; BRCA1; GATA1A; SPATA24|
|protein kinase C binding||PRKCSH; LDB3; AKT2; HDAC7A; TOP2A; GLRX3; SDPRA; SDPR; DACT1; AVPR1A|
|protein kinase binding||PXN; TP73; STK11IP; PPP1R12B; ELP2; CCNE2; ZBTB4; VDAC1; CDC42; DNAJA3|
|repressing transcription factor binding||DDX20; EIF4E; HDAC9; MYC; PRDM5; PARK7; SKI; HDAC4; HMGB1; HDAC1|
|transcription corepressor activity||DRAP1; GMNN; SSX2; TFAP2B; PFDN5; KCTD1; TFCP2L1; HDAC5; KLF12; POU1F1|
|transcription factor binding||APBB3; MED1; ID1; FOXC1; DOT1L; PPP1R13L; TAF7; MYOCD; GCM1; ATG7|
HDAC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC7.
Ywhae; Ncor2; Mef2a; Mef2c