hdac7
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  • Official Full Name
  • histone deacetylase 7
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC7; histone deacetylase 7; HD7A; HDAC7A; HD7; histone deacetylase 7A;
Cat.#:HDAC7-4649HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC7 Protein, GST-tagged
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Cat.#:HDAC7-1594HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Distone Deacetylase 7, GST-tagged
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Cat.#:HDAC7-11HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HDAC7 protein, MYC/DDK-tagged
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Cat.#:HDAC7-13710HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC7, His-tagged
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Cat.#:HDAC7-29191THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC7
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Cat.#:HDAC7-398HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 7, GST-tagged
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Cat.#:HDAC7-98HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC7 Protein, GST-tagged
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Cat.#:HDAC7-7534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC7 Protein
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Cat.#:HDAC7-3053CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDAC7
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Cat.#:Kit-1743Tag:
Source (Host):Species:
Product nameHDAC7 Fluorogenic Assay Kit
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Involved Pathway

HDAC7 involved in several pathways and played different roles in them. We selected most pathways HDAC7 participated on our site, such as Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
PPP1CB; FOSB; HIST1H4N; HDAC3; HIST1H2BG; CAMK4; DDC; PPP1CA; HAT1; GM14483
Viral carcinogenesis
STAT5B; PIK3R3; DLG1; HIST1H4J; BAD; TBP; TRAF1; LYN; HIST1H4D; UBE3A

Protein Function

HDAC7 has several biochemical functions, for example, 14-3-3 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC7 itself. We selected most functions HDAC7 had, and list some proteins which have the same functions with HDAC7. You can find most of the proteins on our site.
Function
Related Protein
Function 14-3-3 protein binding
Related Protein RPTOR; ZFP36; PRKCZ; ARRB2; HDAC7A; KIF13B; DDIT4; HDAC7; AANAT; TSC2
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC7A; HDAC6; HDAC3; HDAC9; HDAC8; HDAC7; HDAC10; HDAC1; HDAC4; HDAC2
Function activating transcription factor binding
Related Protein TAF9; RELA; PRDM16; HDAC7; EP300; ATOH8; HDAC1; ZFP516; GATA4; PPARG
Function chromatin binding
Related Protein EZH2; UPF1; WHSC1; HDGF2; CHAF1A; Ar; ASCL1; POU2F1; HMG20B; ZMYND11
Function histone deacetylase activity
Related Protein HDAC6; HDAC10; MTA2; HDAC1; HDAC5; SIRT1; HDAC3; HDAC7; HDAC2; HDAC11
Function hydrolase activity
Related Protein F2RL1.2; Acr; PPM1E; PPP1CAB; TRY; SERHL2; TMPRSS4B; URAH; THSD4; GNPDA1
Function metal ion binding
Related Protein ZBED1; SPATA21; LMX1BB; KLF11B; ZFP828; PRDM10; PRDM13; HDAC7; CLIP1; ZBTB46
Function protein binding
Related Protein HSD17B8; NAV2; WDR77; NCF1; PRKAR2A; SHFM1; TMEM74; CPEB4; TCTEX1D1; ZBTB16
Function protein kinase C binding
Related Protein HDAC5; ADAM9; GRK5; SQSTM1; TWF2; PKP2; ADD3; PARD6A; PLEK; AKT2
Function protein kinase binding
Related Protein BCAR1; LIMS1; CAMK2N1A; CCNL1; CDC42; CD36; GOLGA2; PPP1R12B; CDK5RAP2; MAP3K1
Function repressing transcription factor binding
Related Protein MAGEA2B; PRDM5; HDAC5; HDAC9; HHEX; HDAC1; SKI; PARK7; RUNX2; CTNNB1
Function transcription corepressor activity
Related Protein YAF2; SRSF2; NR0B1; GMNN; TBL1Y; BCOR; SETD8; JUB; SMARCA4; ZMYND11
Function transcription factor binding
Related Protein NKX3; TBP; CEBPG; TRERF1; TCF12; LMO4; HES4; PURA; EPN1; CTBP1

Interacting Protein

HDAC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC7.
Ywhae; Ncor2; Mef2a; Mef2c

HDAC7 Related Articles

Jin, ZX; Wei, W; et al. HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered beta-Catenin Switch. MOLECULAR ENDOCRINOLOGY 27:325-335(2013).
Hu, N; Long, H; et al. Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:464-471(2009).