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Official Full Name histone deacetylase 7
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms HDAC7; histone deacetylase 7; HD7A; HDAC7A; HD7; histone deacetylase 7A;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Hdac7-3370M Recombinant Mouse Hdac7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HDAC7-4016H Recombinant Human HDAC7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HDAC7-11H Recombinant Human HDAC7 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HDAC7-13710H Recombinant Human HDAC7, His-tagged E.coli His
    Human HDAC7-1594H Recombinant Human Distone Deacetylase 7, GST-tagged Sf9 Insect Cell GST
    Human HDAC7-29191TH Recombinant Human HDAC7 Insect Cell N/A
    Human HDAC7-398H Recombinant Human Histone Deacetylase 7, GST-tagged Insect Cell GST
    Human HDAC7-4649H Recombinant Human HDAC7 Protein, GST-tagged Wheat Germ GST
    Human HDAC7-98H Recombinant Human HDAC7 Protein, GST-tagged Insect Cell GST
    Mouse HDAC7-7534M Recombinant Mouse HDAC7 Protein Mammalian Cell His
    Chicken HDAC7-3053C Recombinant Chicken HDAC7 Mammalian Cell His
    Kit-1743 HDAC7 Fluorogenic Assay Kit N/A

    HDAC7 involved in several pathways and played different roles in them. We selected most pathways HDAC7 participated on our site, such as Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alcoholism CRH; GRB2; GM14477; CAMKK1; CALM3; HIST3H3; NRAS; HIST1H2BJ; MAOB; HIST1H2BD

    HDAC7 has several biochemical functions, for example, 14-3-3 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC7 itself. We selected most functions HDAC7 had, and list some proteins which have the same functions with HDAC7. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding HDAC7; AANAT; DDIT4; IRS2; PPP1R12A; SRPK2; TSC2; KCNH1; YWHAQ; ZFP36
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC9; HDAC8; HDAC3; HDAC2; HDAC1; HDAC11; HDAC7A; HDAC7; HDAC4; HDAC9B
    activating transcription factor binding GATA4; ZFP516; MEF2D; EP300; PPARG; TAF9; DGKQ; MEF2A; PSIP1; EEF1D
    chromatin binding UXT; SMC3; PCGF2; BARX2; LEF1; CDC45; SVEP1; HCFC1; SSRP1; SIN3B
    histone deacetylase activity MTA2; HDAC1; HDAC9; HDAC5; SIRT1; HDAC8; HDAC7; HDAC2; HDAC11; SIRT2
    hydrolase activity CTSL1B; PPAP2C; Reln; USP43; PPP1CBL; CES1C; MMP1A; TMPRSS11G; RHOT1A; GDPD4
    metal ion binding SUCLA2; ADH8B; DPYDB; CTDSPL; ZSWIM7; ZDHHC18; RBAK; ATP2B3A; ZFYVE21; PPM1BA
    protein binding CNOT8; UBA1; CTBP1; GDI2; GHR; C4orf19; ACTB; BRCA1; GATA1A; SPATA24
    protein kinase C binding PRKCSH; LDB3; AKT2; HDAC7A; TOP2A; GLRX3; SDPRA; SDPR; DACT1; AVPR1A
    protein kinase binding PXN; TP73; STK11IP; PPP1R12B; ELP2; CCNE2; ZBTB4; VDAC1; CDC42; DNAJA3
    repressing transcription factor binding DDX20; EIF4E; HDAC9; MYC; PRDM5; PARK7; SKI; HDAC4; HMGB1; HDAC1
    transcription corepressor activity DRAP1; GMNN; SSX2; TFAP2B; PFDN5; KCTD1; TFCP2L1; HDAC5; KLF12; POU1F1
    transcription factor binding APBB3; MED1; ID1; FOXC1; DOT1L; PPP1R13L; TAF7; MYOCD; GCM1; ATG7

    HDAC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC7.

    Ywhae; Ncor2; Mef2a; Mef2c

    Jin, ZX; Wei, W; et al. HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered beta-Catenin Switch. MOLECULAR ENDOCRINOLOGY 27:325-335(2013).
    Hu, N; Long, H; et al. Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:464-471(2009).

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