Recombinant Full Length Human HDAC7 Protein, C-Flag-tagged

• Cat.No.: HDAC7-1522HFL
• Product Overview: Recombinant Full Length Human HDAC7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 106.6 kDa
• AA Sequence: MHSPGADGTQVSPGAHYCSPTGAGC PRPCADTPGPQPQPMDLRVGQRPPV EPPPEPTLLALQRPQRLHHH LFLAGLQQQRSVEPMRLSMDTPMPE LQVGPQEQELRQLLHKDKSKRSAVA SSVVKQKLAEVILKKQQAAL ERTVHPNSPGIPYRTLEPLETEGAT RSMLSSFLPPVPSLPSDPPEHFPLR KTVSEPNLKLRYKPKKSLER RKNPLLRKESAPPSLRRRPAETLGD SSPSSSSTPASGCSSPNDSEHGPNP ILGSEALLGQRLRLQETSVA PFALPTVSLLPAITLGLPAPARADS DRRTHPTLGPRGPILGSPHTPLFLP HGLEPEAGGTLPSRLQPILL LDPSGSHAPLLTVPGLGPLPFHFAQ SLMTTERLSGSGLHWPLSRTRSEPL PPSATAPPPPGPMQPRLEQL KTHVQVIKRSAKPSEKPRLRQIPSA EDLETDGGGPGQVVDDGLEHRELGH GQPEARGPAPLQQHPQVLLW EQQRLAGRLPRGSTGDTVLLPLAQG GHRPLSRAQSSPAAPASLSAPEPAS QARVLSSSETPARTLPFTTG LIYDSVMLKHQCSCGDNSRHPEHAG RIQSIWSRLQERGLRSQCECLRGRK ASLEELQSVHSERHVLLYGT NPLSRLKLDNGKLAGLLAQRMFVML PCGGVGVDTDTIWNELHSSNAARWA AGSVTDLAFKVASRELKNGF AVVRPPGHHADHSTAMGFCFFNSVA IACRQLQQQSKASKILIVDWDVHHG NGTQQTFYQDPSVLYISLHR HDDGNFFPGSGAVDEVGAGSGEGFN VNVAWAGGLDPPMGDPEYLAAFRIV VMPIAREFSPDLVLVSAGFD AAEGHPAPLGGYHVSAKCFGYMTQQ LMNLAGGAVVLALEGGHDLTAICDA SEACVAALLGNRVDPLSEEG WKQKPNLNAIRSLEAVIRVHSKYWG CMQRLASCPDSWVPRVPGADKEEVE AVTALASLSVGILAEDRPSE
  QLVEEEEPMNLTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: HDAC7 histone deacetylase 7 [ Homo sapiens (human) ]
• Official Symbol: HDAC7
• Synonyms: HD7; HD7A; HDAC7A
• Gene ID: 51564
• mRNA Refseq: NM_015401.5
• Protein Refseq: NP_056216.2
• MIM: 606542
• UniProt ID: Q8WUI4