hes1
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  • Official Full Name
  • hairy and enhancer of split 1, (Drosophila)
  • Background
  • This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor;of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that;contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
  • Synonyms
  • HES1; hairy and enhancer of split 1, (Drosophila); hairy homolog (Drosophila) , HRY; transcription factor HES-1; bHLHb39; FLJ20408; HES 1; hairy homolog; hairy-like protein; class B basic helix-loop-helix protein 39; HHL; HRY; HES-1
Cat.#:HES1-4699HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HES1 Protein, GST-tagged
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Cat.#:HES1-141HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HES1 Protein, His-tagged
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Cat.#:HES1-26539THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HES1
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Cat.#:HES1-27078THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HES1
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Cat.#:HES1-289HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HES1, His-tagged
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Cat.#:HES1-7586MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HES1 Protein
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Cat.#:HES1-2829RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HES1 Protein
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Cat.#:HES1-5582HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HES1 293 Cell Lysate
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Involved Pathway

HES1 involved in several pathways and played different roles in them. We selected most pathways HES1 participated on our site, such as Fanconi anemia pathway, Notch signaling pathway, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fanconi anemia pathway
FUZ; DCLRE1A; STRA13; USP1; POLN; PALB2; EME1; PMS2; FANCF; BRCA2
Notch signaling pathway
LFNG; DTX2; DVL3A; TLE3A; DTX3L; HER6; RBPJA; NOTCH1A; NUMBL; DLC
Maturity onset diabetes of the young
HNF1A; IAPP; HES1; NEUROG3; FOXA2; MNX1; PAX4; HHEX; INS; PDX1

Protein Function

HES1 has several biochemical functions, for example, DNA binding, N-box binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HES1 itself. We selected most functions HES1 had, and list some proteins which have the same functions with HES1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SOX1A; MLLT10; ZFP335; DHX36; PUF60; NPAS2; OTX1A; ZNF501; RNF6; ZFP512
Function N-box binding
Related Protein HES1
Function chaperone binding
Related Protein TIMM44; GET4; SLC25A17; DNAJB2; SERPINA7; DNAJA4; ATP1A2; TBCE; TFRC; HES1
Function histone deacetylase binding
Related Protein NIPBL; CRY1; ANKRA2; DDX20; BRMS1; ZNHIT1; MAPK8; TAL1; YWHAE; GMNN
Function protein binding
Related Protein MYL12B; TCHP; DSC2; PLEKHG2; RHOG; FAM189B; LHX9; CCDC103; SMG9; CD22
Function protein homodimerization activity
Related Protein TCF4; CDSN; PEX11A; DNM1L; KCNE2; CBS; TSG101; DMRTC1B; RPE; MAP3K13
Function sequence-specific DNA binding
Related Protein HOXD4A; GATAD2AB; USF2; FOXP1B; HOXD3; HOXA4A; MSXB; GLI2A; HOXB5A; ISL2B
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXO1A; SMAD6A; RBPJL; TBX5A; CITED2; WT1A; ARNT2; EVX1; KLF17; ZNF792
Function transcription factor binding
Related Protein NCOA2; RNF222; CCND1; APBB3; PPID; IFT172; ENPP2; PARP1; JUNBB; SMARCD3
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein POU4F2; DACH1; HINFP; RCOR1; REST; ZFPM2; NFIL3-2; ESRRA; NR2C1; NFATC4

Interacting Protein

HES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HES1.
SIRT1; NUDT3; APCS; GAPDH; ASGR2; NR4A1; YWHAB; HMGCL; LTBR; CSNK1E; PTK2; FHL1; q7cl30_yerpe; moeA2; APH1A; HDAC6

HES1 Related Articles

Otti, GR; Saleh, L; et al. Notch2 Controls Prolactin and Insulin-Like Growth Factor Binding Protein-1 Expression in Decidualizing Human Stromal Cells of Early Pregnancy. PLOS ONE 9:-(2014).
Yan, B; Liu, L; et al. Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells. WORLD JOURNAL OF GASTROENTEROLOGY 20:13105-13118(2014).