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HES1

  • Official Full Name

    hairy and enhancer of split 1, (Drosophila)

  • Overview

    This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor;of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that;contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
  • Synonyms

    HES1; hairy and enhancer of split 1, (Drosophila); hairy homolog (Drosophila) , HRY; transcription factor HES-1; bHLHb39; FLJ20408; HES 1; hairy homolog; hairy-like protein; class B basic helix-loop-helix protein 39; HHL; HRY; HES-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HES1-289H Recombinant Human HES1, His-tagged E.coli His
Human HES1-141H Recombinant Human HES1 Protein, His-tagged E.coli His
Human HES1-4699H Recombinant Human HES1 Protein, GST-tagged Wheat Germ GST
Human HES1-26539TH Recombinant Human HES1 Wheat Germ N/A 80 amino acids
Human HES1-27078TH Recombinant Human HES1 Wheat Germ N/A 107 amino acids
Human HES1-5582HCL Recombinant Human HES1 293 Cell Lysate HEK293 N/A
Human HES1-3515HF Recombinant Full Length Human HES1 Protein, GST-tagged In Vitro Cell Free System GST 277 amino acids
Human HES1-500H Recombinant Human HES1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HES1-1062H Recombinant Human HES1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HES1-2972H Recombinant Human HES1 protein, His-tagged E.coli His 1-277 aa
Human HES1-1831HFL Recombinant Full Length Human HES1 Protein, C-Flag-tagged Mammalian cells Flag
Human HES1-1062H-B Recombinant Human HES1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HES1-7586M Recombinant Mouse HES1 Protein Mammalian Cell His
Mouse HES1-4131M-B Recombinant Mouse HES1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HES1-4131M Recombinant Mouse HES1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hes1-1111M Recombinant Mouse Hes1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HES1-2829R Recombinant Rat HES1 Protein Mammalian Cell His
Rat HES1-2484R Recombinant Rat HES1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HES1-2484R-B Recombinant Rat HES1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HES1 Related Articles
  • HES1 Related Signal Pathway

HES1 involved in several pathways and played different roles in them. We selected most pathways HES1 participated on our site, such as Fanconi anemia pathway, Notch signaling pathway, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fanconi anemia pathwayDCLRE1A;C19orf40;RAD51C;FANCI;FANCA;FANCD2;ZBTB32;USP36;BLM
Notch signaling pathwayDTX4;HDAC2;DVL3A;LNX1;MFNG;KAT2A;KAT2B;DVL1B;DLB
Maturity onset diabetes of the youngMNX1;ONECUT1;PAX6;SLC2A2;BHLHA15;INS1;IAPP;NEUROD1;INS2

HES1 has several biochemical functions, for example, DNA binding, N-box binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HES1 itself. We selected most functions HES1 had, and list some proteins which have the same functions with HES1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingFOXG1C;ZNF670;RPS15;SCML2;NKX2.1;CERS4;ZNF230;SCXB;KCNH7
N-box binding
chaperone bindingHSPA5;DNAJB7;BAG3;SOD1;TFRC;BAG2;BIRC5;AHSA2;DNAJB8
histone deacetylase bindingGMNN;HDAC4;SP2;RBBP4;HDAC5;PARK2;HEY2;MEF2D;GCM1
protein bindingKRTAP5-6;ITGA6;Ctsl;ZNF703;RNF4;SH2D2A;VHL;SELENBP1;MATN2
protein homodimerization activityPON1;SYNDIG1;USF1;CD8A;LILRB1;PVALB;BIRC5;VEGFB;SMAD3
sequence-specific DNA bindingAr;HOXD11A;SP1;FOXO6;RHOXF1;MNX2A;DBPB;DLX2A;ATF4
transcription factor activity, sequence-specific DNA bindingHOXD10;NPAS1;ZNF302;STAT2;FOXB1A;ALS2CR8;RORCB;PTTG1;ZBTB14
transcription factor bindingSRY;SMAD2;MAPK1;DOT1L;TFAP2A;SMARCD3;BCOR;HDAC7;HDAC3
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingNFE2L3;NFIL3-4;MLXIPL;NACC2;HINFP;ASCL1;NKX6-1;BCL11AA;ZNF148

HES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HES1.

SIRT1; NUDT3; APCS; GAPDH; ASGR2; NR4A1; YWHAB; HMGCL; LTBR; CSNK1E; PTK2; FHL1; q7cl30_yerpe; moeA2; APH1A; HDAC6

Otti, GR; Saleh, L; et al. Notch2 Controls Prolactin and Insulin-Like Growth Factor Binding Protein-1 Expression in Decidualizing Human Stromal Cells of Early Pregnancy. PLOS ONE 9:-(2014).
Yan, B; Liu, L; et al. Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells. WORLD JOURNAL OF GASTROENTEROLOGY 20:13105-13118(2014).
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