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HLA-A

  • Official Full Name

    major histocompatibility complex, class I, A

  • Overview

    HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
  • Synonyms

    HLA-A; major histocompatibility complex, class I, A; HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; HLAA; FLJ26655;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • E.coli
  • HEK
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian cells
  • Wheat Germ
  • Avi
  • C
  • His
  • Flag
  • GST
  • Myc
  • B2M
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-A-938H Recombinant Human HLA-A protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HLA-A-4832H Recombinant Human HLA-A Protein, GST-tagged Wheat Germ GST
Human HLA-A-5503HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-A-573HB Recombinant Human HLA-A*0201 NY-ESO-1 (SLLMWITQC) complex protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and SLLMWITQC peptide.
Human HLA-A-732H Recombinant Human HLA-A0201 gp100 (YLEPGPVTA) complex protein, His-Avi-tagged HEK293 His-Avi It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and YLEPGPVTA peptide design.
Human HLA-A-3396H Recombinant Human HLA-A protein, His-tagged E.coli His 28-303 aa
Human HLA-A-068H Recombinant HLA-A*0201 WT-1 (RMFPNAPYL) complex protein, His-Avi-tagged HEK293 His-Avi It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and RMFPNAPYL peptide design
Human HLA-A-2390H Recombinant Human HLA-A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HLA-A-733H Recombinant Human HLA-A0201 MAGE-A4 (GVYDGREHTV) complex protein, His-Avi-tagged HEK293 His-Avi It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and GVYDGREHTV peptide design
Human HLA-A-3958H Recombinant Human HLA-A protein, His-tagged E.coli His 25-308aa
Human HLA-A-069H Recombinant Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein (tetramer), His-Avi-tagged HEK293 His-Avi It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and RMFPNAPYL peptide design.
Human HLA-A-3557HF Recombinant Full Length Human HLA-A Protein, GST-tagged In Vitro Cell Free System GST 24-365 amino acids
Human HLA-A-4302H Recombinant Human HLA-A protein, His-B2M-tagged E.coli His-B2M 25-299aa
Human HLA-A-1448H Recombinant Human HLA-A protein, His-tagged Insect Cell His 25-308aa
Human HLA-A-2242H Recombinant Human HLA-A Protein, His-tagged E.coli N-His Tyr83-Ser352
Human HLA-A-01H Recombinant Human HLA-A Protein, C-His tagged HEK C-His
Human HLA-A-2623HFL Recombinant Full Length Human HLA-A protein, Flag-tagged Mamanlian cells Flag
Human HLA-A-730HP Recombinant Human HLA-A complex Protein (tetramer), His-Avi-tagged, PE-Labeled HEK293 His-Avi Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M) and SLLMWITQC peptide
Human HLA-A-1500H Recombinant Human HLA-A protein, His&Myc-tagged E.coli His&Myc 25-308aa
Human HLA-A-2935H Recombinant Human HLA-A Protein (Gly25-Trp298), N-His tagged E.coli N-His Gly25-Trp298
Human HLA-A-2936H Recombinant Human HLA-A Protein (Gly25-Leu300), N-His tagged E.coli N-His Gly25-Leu300
Human HLA-A-2937H Recombinant Human HLA-A Protein (Full Length), Avi tagged E.coli Avi Full Length
Human HLA-A-2938H Recombinant Human HLA-A Protein (Met1-Pro304), C-His and Avi tagged Mammalian cells C-His and Avi Met1-Pro304
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-A Related Articles
  • HLA-A Related Gene Family
  • HLA-A Related Research Area

HLA-A involved in several pathways and played different roles in them. We selected most pathways HLA-A participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisIL2RGB;IQSEC1;CLINT1A;CXCR1;SMAD3A;LDLRA;SPG20A;SNX6;ARF3
PhagosomeRAB5AA;cgr2b;CD14;TUBA1C;LAMP2;VAMP3;MSR1;CD36;HLA-E
Cell adhesion molecules (CAMs)SELP;CTLA4;CD34;MPZL1L;SDC4;ITGA4;CLDN5A;CD80;CADM1
Antigen processing and presentationHLA-DPA1;IFI30;TAP2;KLRD1;HLA-DRB5;PSME1;HLA-B;HLA-DPB1;LGMN
Natural killer cell mediated cytotoxicityNFATC2;Casp3;ITGB2;MICB;RAC3;NRAS;NCR3;KRAS;PIK3CA
Type I diabetes mellitusCPE;HLA-DQA1;PRF1;HLA-C;HLA-DPA1;IL12A;HLA-DMB;INS1;HLA-DQB1
HTLV-I infectionPOLB;CREM;NFKB1;HLA-DMA;TGFB1;SLC2A1;LTA;WNT9A;TRP53INP1
Herpes simplex infectionSRSF7B;SRSF5B;IFNG1-2;Fasl;NXF1;PPP1CB;TNFRSF14;OAS2;PER1
Epstein-Barr virus infectionCD40;PIK3CA;HSPA1A;PSMC3;HLA-DQB1;RBPJL;RB1;POLR3D;HSPA6
Viral carcinogenesisHIST1H4G;Casp3;MAPKAPK2;ATP6V0D1;HDAC9;BAK1;CREB3L2;RANBP1;CREB3L1
AutoiIFNA10;IFNA2;CD40LG;CD86;IFNA8;HLA-DQA1;IFNA5;Il2;HLA-DMB
ne thyroid diseaseFASLG;IFNA4;HLA-DRB4;FAS;HLA-B;IFNA6;HLA-DOA;IFNA12;IFNA8
Allograft rejectionH2-AB1;HLA-C;HLA-DPA1;MICA;FAS;IL10;Fasl;HLA-B;HLA-DRB3
Graft-versus-host diseaseHLA-F;KIR2DL1;HLA-DMA;HLA-DPB1;IL1A;H2-Q10;HLA-A;PRF1;HLA-B
Viral myocarditisSGCA;HLA-G;MYH7;CD40LG;HLA-A;SGCG;RAC3;SGCD;ACTG1

HLA-A has several biochemical functions, for example, T cell receptor binding, TAP binding, beta-2-microglobulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-A itself. We selected most functions HLA-A had, and list some proteins which have the same functions with HLA-A. You can find most of the proteins on our site.

Function Related Protein
T cell receptor bindingDOCK2;H2-Q10;HLA-A;EPS8L1;FYN;CD3G;CD3E;CD1d1
TAP bindingHLA-A;HLA-C;HLA-B;H2-Q10
beta-2-microglobulin bindingCD1D2;H2-Q10;CD1d1;CD1C;CD1A;CD1B;HFE;HLA-A;HLA-E
peptide antigen bindingMHC1UHA;H2-AB1;CLEC4M;CD209;MHC1UBA;MHC1UEA;HLA-DPB1;HLA-G;HLA-DRA
poly(A) RNA bindingUBE2I;CCDC124;RPL26;MKI67;MAK16;PYDC3;MBNL1;PEBP1;ZCCHC7
protein bindingNSMCE1;ZBTB8A;KRTAP8-1;SYT2;ADAM23;GSG1L;PPM1A;CYB561;PELI2
receptor bindingNOS2;FGF20A;UFD1L;HRG;EDA;MATK;DHRS4;TAC1;FRK

HLA-A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-A here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-A.

B2M; ganglioside_gm1; Cep85l; Bmpr1a; ATXN3; Arhgef17; PCDHB15

Olvera, A; Perez-Alvarez, S; et al. The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression. AIDS 29:507-517(2015).
Kusnierczyk, P; Mozer-Lisewska, I; et al. Contribution of genes for killer cell immunoglobulin-like receptors (KIR) to the susceptibility to chronic hepatitis C virus infection and to viremia. HUMAN IMMUNOLOGY 76:102-108(2015).
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