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HLA-DQA1

  • Official Full Name

    major histocompatibility complex, class II, DQ alpha 1

  • Overview

    HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
  • Synonyms

    CD; GSE; DQ-A1; CELIAC1; HLA-DQA; FLJ27088; FLJ27328; MGC149527; HLA-DQA1; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; DC-alpha; DC-1 alpha chain; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II antigen; leucocyte antigen DQA1; MHC class II HLA-DQ-alpha-1; leukocyte antigen alpha chain; MHC class II surface glycoprotein; MHC class II HLA-D alpha glycoprotein; HLA class II histocompatibility antigen, DQ(W3) alpha chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DQA1-13819H Recombinant Human HLA-DQA1, GST-tagged E.coli GST 24-220a.a.
Human HLA-DQA1-29328TH Recombinant Human HLA-DQA1 Wheat Germ N/A 87 amino acids
Human HLA-DQA1-13815H Recombinant Human HLA-DQA1 protein, His-tagged E.coli His 24-220 aa
Human HLA-DQA1-4844H Recombinant Human HLA-DQA1 Protein, GST-tagged Wheat Germ GST
Human HLA-DQA1-5507HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-DQA1-1075H Recombinant Human HLA-DQA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HLA-DQA1-5291H Recombinant Human HLA-DQA1 protein, His-tagged E.coli His 24-213aa
Human HLA-DQA1-5284H Recombinant Human HLA-DQA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HLA-DQA1-973HFL Recombinant Full Length Human HLA-DQA1 Protein, C-Flag-tagged Mammalian cells Flag
Human HLA-DQA1-1075H-B Recombinant Human HLA-DQA1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HLA-DQA1-2102R Recombinant Rhesus monkey HLA-DQA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HLA-DQA1-1923R Recombinant Rhesus Macaque HLA-DQA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HLA-DQA1-1923R-B Recombinant Rhesus Macaque HLA-DQA1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DQA1 Related Articles
  • HLA-DQA1 Related Gene Family

HLA-DQA1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTHBS1;ATP6V1A;C1R;HLA-DQA2;RAB7A;ATP6V1G1;ACTB1;TUBB2;ATP6V1E1
Cell adhesion molecules (CAMs)CNTN2;PECAM1;ITGB2L;Ntng2;NRXN3A;ESAM;NCAM1A;CD22;NLGN1
Antigen processing and presentationHLA-DOB;HLA-DQA2;HLA-DOA;PSME2;KLRC2;HSPA6;H2-AA;KIR2DS3;TAPBP
Intestinal iHLA-DRB4;HLA-DQB1;IL4;HLA-DOB;MAP3K14;BLB2;ICOS;HLA-DMB;Il2
ne network for IgA productionIl2;IL5;CCR9A;HLA-DMA;MADCAM1;MHC2DEB;HLA-DRA;CCL25;IL15
Type I diabetes mellitusHLA-A;H2-AA;Fasl;INS2;HLA-C;HSPD1;GAD2;FAS;PTPRN
LeishmaniasisFCGR3;PTGS2;FCGR1A;IL12A;HLA-DRB1;HLA-DRA;ITGB1;H2-AA;NCF1
ToxoplasmosisPIK3R2;LAMB3;SOCS1;LAMC1;STAT3;IRAK1;GNAI3;MAPK3;HLA-DQB1
Staphylococcus aureus infectionC3;FCGR1;FCGR2B;PTAFR;FCGR3B;ICAM1;HLA-DOA;HLA-DMB;HLA-DQA2
TuberculosisATP6AP1;TRAF6;TLR4;Casp3;HLA-DOB;EP300;RAB5B;TNF;ATP6V0A2
Influenza AIFNG;HLA-DRA;PIK3CA;TLR3;PIK3R2;TNFRSF10B;IL8L2;HLA-DQA2;IFNB
HTLV-I infectionHLA-DQA2;NFATC3;PRKACG;NFYB;H2-AB1;CCNB2;FZD8;DLG1;PIK3R2
Herpes simplex infectionCCL5;JAK2B;HLA-DRB1;Ifna15;IFNPHI1;IL6;NFKBIA;IFNB;MAPK10
Epstein-Barr virus infectionEIF2AK4;POLR1D;SYK;TAB1;YWHAB;MAPK8;PSMD8;HLA-DQA1;TYK2
AsthmaH2-AB1;IL9;TNF;HLA-DQA1;HLA-DMB;CCL11;HLA-DOB;IL3;HLA-DQA2
AutoiHLA-DMA;IFNA10;FASLG;H2-AB1;IFNA6;HLA-C;HLA-DQA1;CD40;CD86
ne thyroid diseaseIl2;CD40;HLA-C;HLA-DPB1;HLA-DMA;HLA-A;H2-Q10;HLA-DOA;HLA-DQA2
Inflammatory bowel disease (IBD)TGFB1;TLR4;SMAD2;TBX21;IL6;Il23a;HLA-DMA;IL4R;HLA-DQA2
Systemic lupus erythematosusHLA-DRB4;H3F3B;HLA-DRA;HIST1H4A;HIST1H3F;HIST1H2AM;HIST1H2BH;C8A;HIST1H2AE
Rheumatoid arthritisTNFSF13B;ATP6V1C2;TGFB1;ATP6V1B2;ATP6V1D;TEK;H2-AB1;HLA-DRB3;ITGB2
Allograft rejectionHLA-F;HLA-DOA;HLA-DPB1;IL5;H2-AB1;Fasl;PRF1;CD28;HLA-DQB1
Graft-versus-host diseaseHLA-E;IL1A;HLA-DOB;HLA-DRB5;HLA-B;CD28;CD86;TNF;HLA-DOA
Viral myocarditisH2-Q10;CASP9;H2-AA;H2-AB1;HLA-DRB5;RAC3;EIF4G3;ACTB;HLA-A

HLA-DQA1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA1 itself. We selected most functions HLA-DQA1 had, and list some proteins which have the same functions with HLA-DQA1. You can find most of the proteins on our site.

Function Related Protein
MHC class II receptor activityHLA-DOA;HLA-DQA2;HLA-DRB3;HLA-DRB1;HLA-DRA;HLA-DRB4;HLA-DQA1;HLA-DQB1;HLA-DOB
peptide antigen bindingHLA-DRB4;HLA-DRA;MHC1ZDA;HLA-DQB1;MHC1ZE;MHC1UXA2;CLEC4M;H2-AA;MHC1UKA

HLA-DQA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA1.

HLA-DQB1; CD74; HCRT; CDK7; APLP1; TLE1; UNC119; q5ngv3_fratt; RIF1; SH3GL2; IKBKG

Akoglu, G; Metin, A; et al. Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. INTERNATIONAL JOURNAL OF DERMATOLOGY 54:174-178(2015).
Lemin, AJ; Johnson, J; et al. A group-specific sequence-based typing approach for HLA-DQA1. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 42:15-18(2015).
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