hmga1
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  • Official Full Name
  • high mobility group AT-hook 1
  • Synonyms
  • HMGA1; high mobility group AT-hook 1; high mobility group (nonhistone chromosomal) protein isoforms I and Y , HMGIY; high mobility group protein HMG-I/HMG-Y; HMG-I(Y); high mobility group protein R; high mobility group protein A1; nonhistone chromosomal h
Cat.#:HMGA1-3597HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA1, His-tagged
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Cat.#:HMGA1-4435HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA1 Protein, His-tagged
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Cat.#:HMGA1-4437HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA1 Protein, His-tagged
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Cat.#:HMGA1-4863HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HMGA1 Protein, GST-tagged
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Cat.#:Hmga1-174MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hmga1 Protein, His-tagged
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Cat.#:Hmga1-175RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hmga1 Protein, His-tagged
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Cat.#:HMGA1-7725MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HMGA1 Protein
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Cat.#:HMGA1-2865RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HMGA1 Protein
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Cat.#:HMGA1-2107RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HMGA1 Protein, His-tagged
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Cat.#:HMGA1-5939CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HMGA1
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Cat.#:HMGA1-5479HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HMGA1 293 Cell Lysate
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Cat.#:HMGA1-5480HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HMGA1 293 Cell Lysate
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Involved Pathway

HMGA1 involved in several pathways and played different roles in them. We selected most pathways HMGA1 participated on our site, such as 2-LTR circle formation, APOBEC3G mediated resistance to HIV-1 infection, Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
2-LTR circle formation
BANF1; HMGA1; gag; PSIP1
APOBEC3G mediated resistance to HIV-1 infection
PPIA; APOBEC3G; BANF1; PSIP1; gag; HMGA1
Adipogenesis
KLF6; GDF10; KCNA3; BMP1; EPAS1B; GTF3AA; RETN; HMGA1; CNTFR; PLIN2
Autointegration results in viral DNA circles
gag; HMGA1; BANF1; PSIP1
Cellular Senescence
HIST1H1B; SUZ12A; EP400; ACD; POT1; EHMT2; HIST2H3C; BMI1A; HIST3H2BB; CEBPB
Cellular responses to stress
CDKN2C; TNIK; RPS19BP1; MINK1; HSBP1A; DPF1; DYNLL2; CDKN2B; TXN; CBX6
DNA Damage/Telomere Stress Induced Senescence
CABIN1; HIST1H1A; HIST1H1C; HIST1H1E; POT1A; HMGA1; HIST1H1D; H1F0; TINF2; ASF1A
Disease
NA; TRIM24; RCC1; STRA6; DPF1; HEYL; RPL35; KREMEN1; CTBP1; LRRFIP1

Protein Function

HMGA1 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity, AT DNA binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGA1 itself. We selected most functions HMGA1 had, and list some proteins which have the same functions with HMGA1. You can find most of the proteins on our site.
Function
Related Protein
Function 5-deoxyribose-5-phosphate lyase activity
Related Protein XRCC6; HMGA2; HMGA1; HMGA1-RS1
Function AT DNA binding
Related Protein HMGA1; CRIP1; HMGA2; POU3F4; MEF2C
Function DNA binding
Related Protein ASH2L; PML; PHC2; SRY; RORAA; NUCB1; ASXL3; ETV5A; ABI2; MEF2CA
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein NEIL1; HMGA1; HMGA1A; ALKBH1; HMGA1B; APEX1; RPS3; APLF; NEIL2; NEIL3
Function chromatin binding
Related Protein MSL1; TICRR; HDGF2; PDX1; GLI2; GATA2A; MCM5; CENPB; DNAJC2; SSRP1A
Function enzyme binding
Related Protein CAV1; CD40; DNM2; BTG1; MAP2K7; KDM4C; BCHE; Il6ra; PLCB1; ESR2
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein MED30; MED4; MED14; LRP2BP; MED1; PKN1; MED17; ZCCHC18; ACTN1; AASS
Function peroxisome proliferator activated receptor binding
Related Protein PPARGC1A; PRMT2; ASXL2; MED1; IKBKG; NR0B2; HMGA1-RS1; HMGA1; NFATC4; CREBBP
Function protein binding
Related Protein DNA2; CD5; ADAM17; NOP58; NPDC1; FXYD7; TNIP1; ZP3; PFN2; YRDC
Function retinoic acid receptor binding
Related Protein PRAMEF10; LRIF1; PRAMEF1; MED1; SNW1; CTBP2; MED25; RXRA; AASS; ACTN4
Function retinoid X receptor binding
Related Protein FUS; NSD1; NRIP1; VDR; NCOR1; NCOA1; MED25; RARB; NR4A2; HMGA1-RS1
Function transcription factor activity, sequence-specific DNA binding
Related Protein IKZF3; MTA3; SALL1A; RORAB; JUN; TAF13; ZNF584; SCAND3; FOXQ1B; FOXO4
Function transcription factor binding
Related Protein HDAC3; H2-AB1; JUNBA; BCOR; HOXA7; RNF222; GNPTAB; CEBPB; BCL10; UBE2I
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein PBX3; POU4F1; FUBP1; MIXL1; SPI1; BACH1; ARID3B; SFPI1; ZEB2; NFKB1

Interacting Protein

HMGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGA1.
SP1; CEBPB; il2ra_human_gene; il2ra_human_+3317/+3478_dna-probe; Stag2; HSP90AB1; HTT; EWSR1; Kifc5b; ssdna_dadts

HMGA1 Related Articles

Chieffi, P; Chieffi, S; et al. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview. JOURNAL OF CELLULAR PHYSIOLOGY 228:1641-1646(2013).
Chieffi, P; et al. New Prognostic Markers and Potential Therapeutic Targets in Human Testicular Germ Cell Tumors. CURRENT MEDICINAL CHEMISTRY 18:5033-5040(2011).