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Official Full Name 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Synonyms HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) , HMGCS; hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3 hydroxy 3 methylglutaryl coenzyme A (HMG CoA) synthase; cytoplasmic; 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble); 3-hydroxy-3-methylglutaryl coenzyme A synthase; EC; HMCS1_HUMAN; HMG CoA synthase; HMG-CoA synthase; HMGCS; Hydroxymethylglutaryl CoA synthase, cytoplasmic; Hydroxymethylglutaryl-CoA synthase; MGC90332; 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse HMGCS1-1691M Recombinant Mouse HMGCS1 Protein (1-520 aa), His-tagged Yeast His
    Human HMGCS1-171H Recombinant Human HMGCS1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Hmgcs1-3414M Recombinant Mouse Hmgcs1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HMGCS1-6503H Recombinant Human HMGCS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HMGCS1-29335TH Recombinant Human HMGCS1 Wheat Germ N/A
    Human HMGCS1-45H Recombinant Human HMGCS1 protein, His-tagged E.coli His
    Human HMGCS1-4876H Recombinant Human HMGCS1 Protein, GST-tagged Wheat Germ GST
    Human HMGCS1-59H Recombinant Human HMGCS1, His-tagged E.coli His
    Human HMGCS1-803HCL Recombinant Human HMGCS1 cell lysate N/A
    Mouse Hmgcs1-1756M Recombinant Mouse Hmgcs1 protein, His & T7-tagged E.coli His/T7
    Rat HMGCS1-2869R Recombinant Rat HMGCS1 Protein Mammalian Cell His
    Rhesus Macaque HMGCS1-2109R Recombinant Rhesus monkey HMGCS1 Protein, His-tagged Mammalian Cell His
    Chicken HMGCS1-6962C Recombinant Chicken HMGCS1 Mammalian Cell His
    Zebrafish HMGCS1-11309Z Recombinant Zebrafish HMGCS1 Mammalian Cell His

    HMGCS1 involved in several pathways and played different roles in them. We selected most pathways HMGCS1 participated on our site, such as Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Synthesis and degradation of ketone bodies HMGCS1; BDH2; OXCT1; BDH1; OXCT1A; HMGCS2; OXCT1B; ACAT1; HMGCL; OXCT2
    Valine, leucine and isoleucine degradation ALDH2.1; BCKDHA; MCCC2; HSD17B10; ALDH9A1; HMGCS1; BCAT2; OXCT1; ALDH9A1A.1; AOX2P
    Butanoate metabolism ACAT2; OXCT2A; OXCT2; ACSM2B; ACSM1; ACAT1; BDH1; GAD2; EHHADH; L2HGDH
    Terpenoid backbone biosynthesis GGPS1; ACAT1; HMGCR; DHDDS; HMGCRA; HMGCRB; IDI2; PMVK; ZMPSTE24; PDSS2
    Metabolic pathways NT5E; PRODH; DHRS13L1; GLUD1; GART; QDPRB2; NADKD1; PTGES3B; NDUFA8; EXTL3

    HMGCS1 has several biochemical functions, for example, drug binding, hydroxymethylglutaryl-CoA synthase activity, isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCS1 itself. We selected most functions HMGCS1 had, and list some proteins which have the same functions with HMGCS1. You can find most of the proteins on our site.

    Function Related Protein
    drug binding HTR2B; CYP4B1; Alb; TYMS; HMGCS1; FOLR1; CHKA; ACE; PDXK; TLR7
    hydroxymethylglutaryl-CoA synthase activity HMGCS1; HMGCS2
    isomerase activity PDIP5; GPR19; PPIAA; FKBP1AB; ECH1; PGAM1; FKBP1AA; TOP1L; TPI1A; ENOSF1
    organic acid binding HMGCS1; HBA-A2
    protein homodimerization activity TIGIT; FGFR2; ABCB9; MTERFD3; BMP7A; MZF1; ANO6; UGT1A1; NKX2-5; BHLHA15

    HMGCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCS1.

    IKBKE; sdhA; nrdD; polg_hcvjf_rna

    Nakamura, T; Iwase, A; et al. CYP51A1 Induced by Growth Differentiation Factor 9 and Follicle-Stimulating Hormone in Granulosa Cells Is a Possible Predictor for Unfertilization. REPRODUCTIVE SCIENCES 22:377-384(2015).
    Oishi, K; Yamamoto, S; et al. Wheat Alkylresorcinols Suppress High-Fat, High-Sucrose Diet-Induced Obesity and Glucose Intolerance by Increasing Insulin Sensitivity and Cholesterol Excretion in Male Mice. JOURNAL OF NUTRITION 145:199-206(2015).

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