hnf4a
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  • Official Full Name
  • HNF4A hepatocyte nuclear factor 4, alpha
  • Synonyms
  • HNF4A; hepatocyte nuclear factor 4, alpha; MODY, MODY1, TCF14; hepatocyte nuclear factor 4-alpha; HNF4; NR2A1; TCF-14; HNF-4-alpha; HNF4alpha10/11/12; transcription factor 14; transcription factor-14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1; TCF; MODY; MODY1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha; FLJ39654;
Cat.#:HNF4A-4895HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HNF4A Protein, GST-tagged
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Cat.#:HNF4A-28507THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HNF4A
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Cat.#:HNF4A-630HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HNF4A Protein, His-tagged
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Cat.#:HNF4A-7752MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HNF4A Protein
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Cat.#:HNF4A-2550CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HNF4A
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Cat.#:HNF4A-9719ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HNF4A
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Cat.#:HNF4A-5456HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HNF4A 293 Cell Lysate
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Cat.#:HNF4A-5457HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HNF4A 293 Cell Lysate
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Cat.#:HNF4A-5458HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HNF4A 293 Cell Lysate
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Cat.#:HNF4A-5459HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HNF4A 293 Cell Lysate
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Involved Pathway

HNF4A involved in several pathways and played different roles in them. We selected most pathways HNF4A participated on our site, such as AMPK signaling pathway, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF4A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AMPK signaling pathway
PIK3R3; PRKAB1; CD36; PCK1; TSC1; INSR; PPP2R5D; CAMKK2; IRS4; HNF4A
Maturity onset diabetes of the young
HHEX; PAX4; PAX6; NR5A2; SLC2A2; MNX1; HNF4A; ONECUT1; FOXA3; MAFA

Protein Function

HNF4A has several biochemical functions, for example, DNA binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF4A itself. We selected most functions HNF4A had, and list some proteins which have the same functions with HNF4A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein DDX3Y; ZNF35; LCORL; C14orf43; HNF1BA; MYCN; FOXO4; LIG4; JUNBA; ZFP287
Function RNA polymerase II activating transcription factor binding
Related Protein NEUROD1; DUSP26; CTNNB1; NHLH2; SMAD3; EOMES; TBX20; CREBBP; HIPK2; HNF4A
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein SP3; NSD1; TP53; SPI1; H3F3A; WBP2; SOX3; SMAD1; NLRC5; PAX8
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein PPARD; PPARAB; NR1D2; NR2F6; ESR2; STAT3; PPARG; NR5A2; NR5A5; HNF4G
Function fatty acid binding
Related Protein FABP7A; O3far1; FABP1A; FABP7B; ACOX2; FABP1B.1; FABP10A; FABP4; FABP5; PMP2
Function protein binding
Related Protein CDH1; WDTC1; UNC45B; SOCS1; VPS45; SH3GL2; TSPAN6; MYH11; RNF4; PAFAH1B1
Function protein homodimerization activity
Related Protein PRPS1; BHLHE40; KCNK3; HNF4A; TPR; VOX; PKD2; NPM1; NAGA; BHLHB9
Function receptor binding
Related Protein WNT7A; HLA-E; DIAPH1; LAMA3; CD2; PRDX5; FGF20A; F7; WIPI1; PLA2G1B
Function steroid hormone receptor activity
Related Protein GPR30; ESR2; RARGA; NR2C2; NR5A1; NR5A1A; NR4A2B; NR5A5; RARG; THRA
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein GATA4; RFX1; IRF8; MYF6; SOX17; SFPI1; NKX2-5; TLE4; OLIG2; PAX3
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZFY1; MYCB; NR2F2; ZNF263; ZNF26; MYRFL; RCOR2; DMBX1; ZNF354B; INSM1A
Function transcription regulatory region DNA binding
Related Protein BRD7; CTCFL; ZFP821; FOS; RCOR1; GATA6; BCL11AB; XRCC6; ZBTB14; JUN
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein OTX1; FUBP3; ARID3B; STK16; FOXA1; POU4F1; MTF1; NFIA; CREB3L2; WT1
Function zinc ion binding
Related Protein AIRE; QPCTLA; ADAM10; PGLYRP1; TRIM11; ZYX; NR1I3; RNF20; LMO7; GRIN2B

Interacting Protein

HNF4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF4A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF4A.
PPARGC1A; st2a1_human_hnf4a-6160-site_dna-probe

HNF4A Related Articles

Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).
Pihoker, C; Gilliam, LK; et al. Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98:4055-4062(2013).