HNF4A Protein, HNF4A hepatocyte nuclear factor 4, alpha


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Official Full Name HNF4A hepatocyte nuclear factor 4, alpha
Synonyms HNF4A; hepatocyte nuclear factor 4, alpha; MODY, MODY1, TCF14; hepatocyte nuclear factor 4-alpha; HNF4; NR2A1; TCF-14; HNF-4-alpha; HNF4alpha10/11/12; transcription factor 14; transcription factor-14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1; TCF; MODY; MODY1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha; FLJ39654;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Hnf4a-1147M Recombinant Mouse Hnf4a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HNF4A-28507TH Recombinant Human HNF4A Wheat Germ N/A
    Human HNF4A-4895H Recombinant Human HNF4A Protein, GST-tagged Wheat Germ GST
    Human HNF4A-5456HCL Recombinant Human HNF4A 293 Cell Lysate HEK293 N/A
    Human HNF4A-5457HCL Recombinant Human HNF4A 293 Cell Lysate HEK293 N/A
    Human HNF4A-5458HCL Recombinant Human HNF4A 293 Cell Lysate HEK293 N/A
    Human HNF4A-5459HCL Recombinant Human HNF4A 293 Cell Lysate HEK293 N/A
    Human HNF4A-630H Recombinant Human HNF4A Protein, His-tagged E.coli His
    Mouse HNF4A-7752M Recombinant Mouse HNF4A Protein Mammalian Cell His
    Chicken HNF4A-2550C Recombinant Chicken HNF4A Mammalian Cell His
    Zebrafish HNF4A-9719Z Recombinant Zebrafish HNF4A Mammalian Cell His

    HNF4A involved in several pathways and played different roles in them. We selected most pathways HNF4A participated on our site, such as AMPK signaling pathway, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AMPK signaling pathway CREB3L3; ACACB; PPP2R5D; PPARGC1A; PPP2R3C; RAB11B; PDPK1; AKT1; PPP2CA; SCD
    Maturity onset diabetes of the young HNF1A; HNF4A; HES1; PDX1; MAFA; PAX6; INS2; MNX1; HHEX; HNF1B

    HNF4A has several biochemical functions, for example, DNA binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF4A itself. We selected most functions HNF4A had, and list some proteins which have the same functions with HNF4A. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZNF701; ZNF436; POLM; BCLAF1; HNF1B; TOX4; TOMM20A; MCM9; ZNF559; PRM1
    RNA polymerase II activating transcription factor binding POU1F1; ISL1; BEX1; EGR2; EP300; CREBBP; HIPK2; TBX3; HEY2; MAD2L2
    RNA polymerase II core promoter sequence-specific DNA binding HOXB3; SPI1; SP3; PAX6; HNF4A; SP1; IRF7; EP300; TCF7L2; TP53
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR5A2; NR1H4; RORA; PPARA; RORB; PPARDB; RORCA; ESRRA; NR2F6; NR2F2
    fatty acid binding APOC1; HNF4A; FABP4; CYP4A14; GPR120; ADH5; Alb; FABP1B.1; ACOX2; FABP7B
    protein binding PPIL2; WBP1; LATS2; EFNA4; LAMP2; RBCK1; CC10; PHF16; RET; CAV1
    protein homodimerization activity ADRA2C; IKZF3; IL6R; GPD1B; NPR3; ABCD1; DEM1; BOKB; GCH1; PTPRO
    receptor binding HLA-B; CAT; PLXNC1; TYROBP; GIPC1; CADM2; WIPI1; FGF12B; MATK; FKBP1B
    steroid hormone receptor activity NR6A1A; OLFR78; RXRG; NR0B2A; NR1D2; NR2F6B; NR5A1B; RORA; NR2F6A; PPARDB
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding HIF1A; ATF1; GATA4; NR5A1; MEF2A; SNAI2; FOXC2; NKX2-5; JUN; SOX7
    transcription factor activity, sequence-specific DNA binding NFYB; ZFY2; TCF19; HIVEP2; T; NKX6-1; EGR1; HNF4G; ZNF192; STAT6
    transcription regulatory region DNA binding THRA; SOX6; TAL1; HIVEP2; RELA; TBL1X; ZFP161; H2AFY2; SALL1A; H2AFY
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HLTF; TFAP2B; MTF1; RUNX2; TRP53; GRHL1; TLX1; CEBPA; TP73; SIX2
    zinc ion binding SLC30A8; CBLL1; ADAMTS12; GTF2H2C; SHANK3; MMEL1; CXXC5; PNMA3; LMO7B; SETMAR

    HNF4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF4A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF4A.

    PPARGC1A; st2a1_human_hnf4a-6160-site_dna-probe

    Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).
    Pihoker, C; Gilliam, LK; et al. Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98:4055-4062(2013).

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