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HPD

  • Official Full Name

    4-hydroxyphenylpyruvate dioxygenase

  • Overview

    The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HPD; 4-hydroxyphenylpyruvate dioxygenase; PPD; 4 HPPD; 4HPPD; GLOD3; glyoxalase domain containing 3; 4 hydroxyphenylpyruvate dioxygenase; 4 hydroxyphenylpyruvic acid oxidase; HPPDase; OTTHUMP00000240051; OTTHUMP00000240052; 4-hydroxyphenylpyruvic acid oxidase; 4-HPPD;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HPD-1705H Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase, His-tagged Human His
Human HPD-5006H Recombinant Human HPD Protein, GST-tagged Wheat Germ GST
Human HPD-2842H Recombinant Human HPD, His-tagged E.coli His
Human HPD-28754TH Recombinant Human HPD N/A
Human HPD-13920H Recombinant Human HPD, His-tagged E.coli His 1-393 aa
Human HPD-5404HCL Recombinant Human HPD 293 Cell Lysate HEK293 N/A
Human HPD-3621HF Recombinant Full Length Human HPD Protein, GST-tagged In Vitro Cell Free System GST 393 amino acids
Human HPD-01H Recombinant Human HPD Protein, His-tagged Human Cells His
Human HPD-4257H Recombinant Human HPD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HPD-3050H Recombinant Human HPD protein, His-tagged E.coli His 2-393aa
Human HPD-0404H Recombinant Human HPD Protein (Met1-Met393), N-His-tagged E.coli N-His Met1-Met393
Human HPD-2841H Recombinant Human HPD Protein (Thr2-Met393), His tagged E.coli His Thr2-Met393
Mouse HPD-7827M Recombinant Mouse HPD Protein Mammalian Cell His
Mouse HPD-4305M-B Recombinant Mouse HPD Protein Pre-coupled Magnetic Beads HEK293
Mouse HPD-4305M Recombinant Mouse HPD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hpd-1163M Recombinant Mouse Hpd Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HPD-2900R Recombinant Rat HPD Protein Mammalian Cell His
Rat HPD-2555R Recombinant Rat HPD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HPD-2555R-B Recombinant Rat HPD Protein Pre-coupled Magnetic Beads HEK293
Chicken HPD-4884C Recombinant Chicken HPD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HPD Related Articles

HPD involved in several pathways and played different roles in them. We selected most pathways HPD participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquinone and other terpenoid-quinone biosynthesisAMOTL1;HPDA;GGCX;VKORC1;HPDB;COQ5;TAT;COQ2;VKORC1L1
Tyrosine metabolismHGD;ADH2-1;COMTA;PNMT;AOX3L1;HPDB;TYRP1;GOT2A;AOC2
Phenylalanine metabolismKEG1;GM4952;HPDA;IL4I1;PAH;AOC3;ALDH3B2;TAT;GOT2A
Metabolic pathwaysCDO1;NADKD1;CYP27A1;SORD;IL4I1;AK5;NDUFS6;AGK;ATP5J2

HPD has several biochemical functions, for example, 4-hydroxyphenylpyruvate dioxygenase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPD itself. We selected most functions HPD had, and list some proteins which have the same functions with HPD. You can find most of the proteins on our site.

Function Related Protein
4-hydroxyphenylpyruvate dioxygenase activityHPDL;HPDB;HPD;HPDA
metal ion bindingDNMT3B;ZNF10;FOXP1;POLA1;CA5;CNDP1;ZNF100;PRKCBA;ATP13A5

HPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPD here. Most of them are supplied by our site. Hope this information will be useful for your research of HPD.

HIVEP1; CDKN1A; HRSP12; IKBKG

Martinelli, M; Frati, ER; et al. Phylogeny and population dynamics of respiratory syncytial virus (Rsv) A and B. VIRUS RESEARCH 189:293-302(2014).
da Silva, RM; et al. Anti-PD-1 monoclonal antibody Cancer immunotherapy. DRUGS OF THE FUTURE 39:15-24(2014).
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