HPD Protein, 4-hydroxyphenylpyruvate dioxygenase


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Official Full Name 4-hydroxyphenylpyruvate dioxygenase
Background The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms HPD; 4-hydroxyphenylpyruvate dioxygenase; PPD; 4 HPPD; 4HPPD; GLOD3; glyoxalase domain containing 3; 4 hydroxyphenylpyruvate dioxygenase; 4 hydroxyphenylpyruvic acid oxidase; HPPDase; OTTHUMP00000240051; OTTHUMP00000240052; 4-hydroxyphenylpyruvic acid oxidase; 4-HPPD
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Hpd-1163M Recombinant Mouse Hpd Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HPD-13920H Recombinant Human HPD, GST-tagged E.coli GST
    Human HPD-1705H Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase, His-tagged Human His
    Human HPD-2842H Recombinant Human HPD, His-tagged E.coli His
    Human HPD-28754TH Recombinant Human HPD N/A
    Human HPD-5006H Recombinant Human HPD Protein, GST-tagged Wheat Germ GST
    Human HPD-5404HCL Recombinant Human HPD 293 Cell Lysate HEK293 N/A
    Mouse HPD-7827M Recombinant Mouse HPD Protein Mammalian Cell His
    Rat HPD-2900R Recombinant Rat HPD Protein Mammalian Cell His
    Chicken HPD-4884C Recombinant Chicken HPD Mammalian Cell His

    HPD involved in several pathways and played different roles in them. We selected most pathways HPD participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquinone and other terpenoid-quinone biosynthesis HPD; VKORC1L1; COQ5; GGCX; COQ7; COQ6; TAT; COQ3; HPDA; COQ2
    Tyrosine metabolism PNMT; AOX3L1; FAH; GOT2A; TYRP1; TAT; ALDH3B1; COMTA; MAOA; ADH2-1
    Phenylalanine metabolism HPDB; ALDH3A1; ALDH1A3; GOT2; MIF; MAOA; AOC2; HPDA; GOT2A; ALDH3B1
    Metabolic pathways GPAA1; IPPK; PTGES3B; CYP4F3; ACAT1; GUK1; PET112L; ASL2; BDH2; HAO1

    HPD has several biochemical functions, for example, 4-hydroxyphenylpyruvate dioxygenase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPD itself. We selected most functions HPD had, and list some proteins which have the same functions with HPD. You can find most of the proteins on our site.

    Function Related Protein
    4-hydroxyphenylpyruvate dioxygenase activity HPDA; HPDB; HPDL; HPD
    metal ion binding GALNT4; ZEB2B; GTF3A; IKZF2; GRIN2A; ZNF581; ZBTB43; CPPED1; TRMT44; IMPDH1B

    HPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPD here. Most of them are supplied by our site. Hope this information will be useful for your research of HPD.


    Martinelli, M; Frati, ER; et al. Phylogeny and population dynamics of respiratory syncytial virus (Rsv) A and B. VIRUS RESEARCH 189:293-302(2014).
    da Silva, RM; et al. Anti-PD-1 monoclonal antibody Cancer immunotherapy. DRUGS OF THE FUTURE 39:15-24(2014).

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