HRK
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Official Full Name
harakiri, BCL2 interacting protein (contains only BH3 domain)
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Overview
Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL -
Synonyms
HRK; DP5; HARAKIRI; harakiri, BCL2 interacting protein (contains only BH3 domain); activator of apoptosis hara-kiri; activator of apoptosis Hrk; Neuronal death protein DP5; BCL2-interacting protein; BH3-interacting domain-containing protein 3; death protein 5; harakiri, BCL2-interacting protein (contains only BH3 domain); BID3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- HRK Related Articles
- HRK Related Research Area
HRK involved in several pathways and played different roles in them. We selected most pathways HRK participated on our site, such as ATF-2 transcription factor network, Apoptosis, Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ATF-2 transcription factor network | ATF2;DUSP1;DUSP5;GADD45A;CSRP2;DDIT3;DUSP10;HRK;KCNA3 |
Apoptosis | DIABLOB;PIK3R2;PIK3CD;CAPN2;IL1RAP;JUN;TNFRSF10A;BNIP3L;IL3RA |
Apoptosis Modulation and Signaling | BLK;DFFA;CAPNS1;DIABLO;CASP2;HRK;HN1;BAG3;PTPN13 |
HRK has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HRK itself. We selected most functions HRK had, and list some proteins which have the same functions with HRK. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | TRAF3IP3;SNX32;PRH1;BNIPL;CORO1C;MECP2;VPS45;CTNNBL1;PEX5 |
HRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRK here. Most of them are supplied by our site. Hope this information will be useful for your research of HRK.
BCL2L1; C1QBP; Bcl2a1; BCL2L1; BCL2L2; Bcl2l1; C1QBP; MCL1
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