hs2st1
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  • Official Full Name
  • heparan sulfate 2-O-sulfotransferase 1
  • Background
  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
  • Synonyms
  • HS2ST1; heparan sulfate 2-O-sulfotransferase 1; KIAA0448; 2OST; 2-O-sulfotransferase; dJ604K5.2; FLJ11317; MGC131986
Cat.#:HS2ST1-5047HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HS2ST1 Protein, GST-tagged
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Cat.#:HS2ST1-105HTag:HIS
Source (Host):CHOSpecies:Human
Product nameRecombinant Human HS2ST1, His-tagged
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Cat.#:HS2ST1-1591HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HS2ST1 protein, His & T7-tagged
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Cat.#:HS2ST1-7855MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HS2ST1 Protein
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Cat.#:HS2ST1-2145RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HS2ST1 Protein, His-tagged
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Cat.#:HS2ST1-6051CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HS2ST1
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Cat.#:HS2ST1-5388HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HS2ST1 293 Cell Lysate
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Involved Pathway

HS2ST1 involved in several pathways and played different roles in them. We selected most pathways HS2ST1 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, which may be useful for your reference. Also, other proteins which involved in the same pathway with HS2ST1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
EXT1A; HS6ST3; HS3ST3B1; HS6ST2; HS3ST5; HS6ST1A; EXT1C; NDST1; XYLT2; EXTL1

Protein Function

HS2ST1 has several biochemical functions, for example, heparan sulfate 2-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HS2ST1 itself. We selected most functions HS2ST1 had, and list some proteins which have the same functions with HS2ST1. You can find most of the proteins on our site.
Function
Related Protein
Function heparan sulfate 2-O-sulfotransferase activity
Related Protein CHST2A; SULT1ST7; CHST3A; SULT1ST1; HS3ST1L1; SULT2ST1; SULT3ST3; GAL3ST3; HS3ST3B1A; CHST2

Interacting Protein

HS2ST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HS2ST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HS2ST1.
ssrna_ag

HS2ST1 Related Articles

Nakayama, F; Hagiwara, A; et al. Hydrogen peroxide as a potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes. CELLULAR & MOLECULAR BIOLOGY LETTERS 13:475-492(2008).