hsd17b4
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  • Official Full Name
  • hydroxysteroid (17-beta) dehydrogenase 4
  • Background
  • The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.
  • Synonyms
  • HSD17B4; hydroxysteroid (17-beta) dehydrogenase 4; peroxisomal multifunctional enzyme type 2; 3 alpha; 7 alpha; 12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase 4; 17beta estradiol dehydrogena
Cat.#:HSD17B4-1417HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human HSD17B4 Protein (1-736 aa), His-tagged
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Cat.#:HSD17B4-109HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human HSD17B4, His-tagged
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Cat.#:HSD17B4-110HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HSD17B4 protein, MYC/DDK-tagged
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Cat.#:HSD17B4-111HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HSD17B4 protein, GST-tagged
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Cat.#:HSD17B4-13960HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSD17B4, GST-tagged
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Cat.#:HSD17B4-7879MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HSD17B4 Protein
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Cat.#:HSD17B4-2928RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HSD17B4 Protein
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Cat.#:HSD17B4-6503CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HSD17B4
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Cat.#:HSD17B4-10487ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HSD17B4
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Cat.#:HSD17B4-5373HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HSD17B4 293 Cell Lysate
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Involved Pathway

HSD17B4 involved in several pathways and played different roles in them. We selected most pathways HSD17B4 participated on our site, such as Primary bile acid biosynthesis, Metabolic pathways, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Primary bile acid biosynthesis
CYP7B1; HSD3B7; AMACR; CYP7A1A; CH25H; CYP46A1.3; CH25HL2; AKR1C4; CYP39A1; BRSK2
Metabolic pathways
PRPS1L1; MGAT2; GCLC; ALDH3B1; SPHK2; COX4I1; NDUFA4L2; LIAS; ITPKA; NAMPTB
Peroxisome
ACOX3; SLC27A2; AMACR; CROT; AGXTB; DAO.3; PEX13; CRATA; ACSL1A; PAOX

Protein Function

HSD17B4 has several biochemical functions, for example, 17-beta-hydroxysteroid dehydrogenase (NAD+) activity, 3-hydroxyacyl-CoA dehydrogenase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B4 itself. We selected most functions HSD17B4 had, and list some proteins which have the same functions with HSD17B4. You can find most of the proteins on our site.
Function
Related Protein
Function 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
Related Protein HSD17B4
Function 3-hydroxyacyl-CoA dehydrogenase activity
Related Protein EHHADH; H2-KE6; HSD17B8; HADHB; HADHAB; HSD17B4; HADHAA; HADHA; HSD17B10; HADH
Function 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
Related Protein HSD17B4
Function isomerase activity
Related Protein PPIAB; FKBP1AB; PTGESL; PGAM1; ENOSF1; PGAM1B; GPIB; PBLD1; TOP1L; TSTA3
Function long-chain-enoyl-CoA hydratase activity
Related Protein HADHA; HSD17B4
Function protein homodimerization activity
Related Protein GRPEL1; NCR3; TENM3; BCL2A; UGT1A9; BMPR1A; EIF2AK1; IKZF2; CHMP1A; IDE
Function receptor binding
Related Protein CAPRIN2; AMACR; ABL1; TGFB2; FGF12A; PVR; DECR2; TAC4; RSPO3; NPPC

Interacting Protein

HSD17B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B4.
PLEK; GSK3B; RELB; NDRG1; UBA5; MAPK8; CDK7; CASP9; BAK1; q74yg8_yerpe; midostaurin; ssrna_ag