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HSD17B4

  • Official Full Name

    hydroxysteroid (17-beta) dehydrogenase 4

  • Overview

    The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.
  • Synonyms

    HSD17B4; hydroxysteroid (17-beta) dehydrogenase 4; peroxisomal multifunctional enzyme type 2; 3 alpha; 7 alpha; 12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase 4; 17beta estradiol dehydrogena;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSD17B4-109H Recombinant Human HSD17B4, His-tagged HEK293 His
Human HSD17B4-13960H Recombinant Human HSD17B4, GST-tagged E.coli GST 436-736a.a.
Human HSD17B4-110H Recombinant Human HSD17B4 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HSD17B4-111H Recombinant Human HSD17B4 protein, GST-tagged Wheat Germ GST 1 a.a. - 736 a.a.
Human HSD17B4-5373HCL Recombinant Human HSD17B4 293 Cell Lysate HEK293 N/A
Human HSD17B4-429HFL Recombinant Full Length Human HSD17B4 Protein, C-Flag-tagged Mammalian cells Flag
Human HSD17B4-1417H Recombinant Human HSD17B4 Protein (1-736 aa), His-tagged Yeast His 1-736 aa
Human HSD17B4-1106H Recombinant Human HSD17B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSD17B4-712HF Recombinant Full Length Human HSD17B4 Protein, GST-tagged In Vitro Cell Free System GST 736 amino acids
Human HSD17B4-1106H-B Recombinant Human HSD17B4 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSD17B4-7879M Recombinant Mouse HSD17B4 Protein Mammalian Cell His
Mouse HSD17B4-4336M Recombinant Mouse HSD17B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HSD17B4-4336M-B Recombinant Mouse HSD17B4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Hsd17b4-1180M Recombinant Mouse Hsd17b4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HSD17B4-2928R Recombinant Rat HSD17B4 Protein Mammalian Cell His
Rat HSD17B4-2583R-B Recombinant Rat HSD17B4 Protein Pre-coupled Magnetic Beads HEK293
Rat HSD17B4-2583R Recombinant Rat HSD17B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HSD17B4-10487Z Recombinant Zebrafish HSD17B4 Mammalian Cell His
Chicken HSD17B4-6503C Recombinant Chicken HSD17B4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HSD17B4 involved in several pathways and played different roles in them. We selected most pathways HSD17B4 participated on our site, such as Primary bile acid biosynthesis, Metabolic pathways, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Primary bile acid biosynthesisBAAT;HSD3B7;SCP2;SCP2A;CH25HL2;CYP7A1A;AKR1C4;CH25H;CYP46A1
Metabolic pathwaysDHRS13L1;GALNT11;GRHPRA;ASL2;CYP2C39;MTMR14;IMPDH1B;CYP19A1;PPCS
PeroxisomeECH1;IDH2;ACSL4;HACL1;PEX5;ACSL1;ACOX2;PEX11A;FAR1

HSD17B4 has several biochemical functions, for example, 17-beta-hydroxysteroid dehydrogenase (NAD+) activity, 3-hydroxyacyl-CoA dehydrogenase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B4 itself. We selected most functions HSD17B4 had, and list some proteins which have the same functions with HSD17B4. You can find most of the proteins on our site.

Function Related Protein
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
3-hydroxyacyl-CoA dehydrogenase activityHADHB;HADHAA;HADHAB;HADH;H2-KE6;HADHA;EHHADH;HSD17B8;HSD17B10
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
isomerase activityPGAM1A;TPI1A;TOP1L;GPIB;GSBP9;PDIA5;FKBP10B;ECI2;BPGM
long-chain-enoyl-CoA hydratase activityHADHA;HSD17B4
protein homodimerization activityASNS;USH1G;LILRB1;BHLHE40;PAFAH1B2;CTBP2;RENBP;WHRN;MAOB
receptor bindingPICK1;SNX17;NUDT7;RIPK2;FGF8A;CXCL1;CADM2;ACOX3;EPHX2

HSD17B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B4.

PLEK; GSK3B; RELB; NDRG1; UBA5; MAPK8; CDK7; CASP9; BAK1; q74yg8_yerpe; midostaurin; ssrna_ag

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