hsd17b8
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  • Official Full Name
  • hydroxysteroid (17-beta) dehydrogenase 8
  • Background
  • Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) as
  • Synonyms
  • HSD17B8; hydroxysteroid (17-beta) dehydrogenase 8; FabG (beta ketoacyl [acyl carrier protein] reductase, E coli) like (E. coli) , FABGL; estradiol 17-beta-dehydrogenase 8; D6S2245E; H2 KE6; HKE6; KE6; RING2; SDR30C1; short chain dehydrogenase/reductase fa
Cat.#:HSD17B8-5076HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HSD17B8 Protein, GST-tagged
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Cat.#:HSD17B8-13964HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSD17B8, GST-tagged
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Cat.#:HSD17B8-29342THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSD17B8, His-tagged
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Cat.#:HSD17B8-3499HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSD17B8, His-tagged
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Cat.#:HSD17B8-2931RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HSD17B8 Protein
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Cat.#:HSD17B8-603CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus HSD17B8 Protein, His-tagged
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Cat.#:HSD17B8-2157RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HSD17B8 Protein, His-tagged
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Cat.#:HSD17B8-1393ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HSD17B8
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Cat.#:HSD17B8-5371HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HSD17B8 293 Cell Lysate
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Involved Pathway

HSD17B8 involved in several pathways and played different roles in them. We selected most pathways HSD17B8 participated on our site, such as Steroid hormone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Steroid hormone biosynthesis
UGT1A6; AKR1C3; PPP1R2; CYP2C45; HSD11B1; HSD17B12; COMTA; CYP2B19; HSD3B4; HSD3B6
Metabolic pathways
PTGESL; DHRS9; ALDH4A1; GBA2; UQCR10; ASMT; IVD; FDFT1; B3GNT5B; Cel

Protein Function

HSD17B8 has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity, estradiol 17-beta-dehydrogenase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B8 itself. We selected most functions HSD17B8 had, and list some proteins which have the same functions with HSD17B8. You can find most of the proteins on our site.
Function
Related Protein
Function 3-hydroxyacyl-CoA dehydrogenase activity
Related Protein EHHADH; HADHA; HADHAB; HADHB; H2-KE6; HADHAA; HSD17B4; HSD17B10; HADH; HSD17B8
Function estradiol 17-beta-dehydrogenase activity
Related Protein HSD17B7; HSD17B1; HSD17B12B; HSD17B8; HSD17B12A; HSD17B11; HSD17B14; HSD17B10; HSD17B6; RDH8
Function protein binding
Related Protein KCNN4; ARPC3; CEP55; CELSR1; ADI1; IFI16; BBS2; CCDC68; ARF1; TMED2
Function testosterone dehydrogenase (NAD+) activity
Related Protein AKR1C3; DHRS9; HSD17B2; HSD17B8; HSD17B6; H2-KE6; HSD17B1

Interacting Protein

HSD17B8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B8.
ssrna_ac

HSD17B8 Related Articles

Yang, FQ; Priester, S; et al. Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 301:G981-G991(2011).
Motohara, K; Tashiro, H; et al. Immunohistochemical analysis of 17 beta-hydroxysteroid dehydrogenase isozymes in human ovarian surface epithelium and epithelial ovarian carcinoma. MEDICAL MOLECULAR MORPHOLOGY 43:197-203(2010).