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HSD3B1

  • Official Full Name

    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

  • Overview

    3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.
  • Synonyms

    HSD3B1; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; HSD3B, HSDB3; 3 beta-hydroxysteroid dehydrogenase/Delta 5--> 4-isomerase type 1; SDR11E1; short chain dehydrogenase/reductase family 11E; member 1; 3 beta-hydroxystero;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mesocricetus auratus (Golden hamster)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSD3B1-5078H Recombinant Human HSD3B1 Protein, GST-tagged Wheat Germ GST
Human HSD3B1-5370HCL Recombinant Human HSD3B1 293 Cell Lysate HEK293 N/A
Human HSD3B1-1110H Recombinant Human HSD3B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSD3B1-1110H-B Recombinant Human HSD3B1 Protein Pre-coupled Magnetic Beads HEK293
Human HSD3B1-4934H Recombinant Human HSD3B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSD3B1-22H Recombinant Human HSD3B1 protein, Myc/DDK-tagged HEK293 Myc/DDK
Human HSD3B1-5862H Recombinant Human HSD3B1 protein, His&Myc-tagged E.coli His&Myc 2-237aa
Human HSD3B1-3882HF Recombinant Full Length Human HSD3B1 Protein, GST-tagged In Vitro Cell Free System GST 373 amino acids
Human HSD3B1-1705HFL Recombinant Full Length Human HSD3B1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse HSD3B1-7882M Recombinant Mouse HSD3B1 Protein Mammalian Cell His
Mouse HSD3B1-4339M Recombinant Mouse HSD3B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hsd3b1-1182M Recombinant Mouse Hsd3b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HSD3B1-4339M-B Recombinant Mouse HSD3B1 Protein Pre-coupled Magnetic Beads HEK293
Rat HSD3B1-2933R Recombinant Rat HSD3B1 Protein Mammalian Cell His
Rat HSD3B1-2588R-B Recombinant Rat HSD3B1 Protein Pre-coupled Magnetic Beads HEK293
Rat HSD3B1-2588R Recombinant Rat HSD3B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL30251HF Recombinant Full Length Human 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1(Hsd3B1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-373)
Macaca mulatta (Rhesus macaque) RFL12014MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1(Hsd3B1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-373)
Mesocricetus auratus (Golden hamster) RFL6400MF Recombinant Full Length Mesocricetus Auratus 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1(Hsd3B1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-373)
Mus musculus (Mouse) RFL4903MF Recombinant Full Length Mouse 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1(Hsd3B1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-373)
Rattus norvegicus (Rat) RFL1550RF Recombinant Full Length Rat 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1(Hsd3B1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-373)
Zebrafish HSD3B1-12064Z Recombinant Zebrafish HSD3B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSD3B1 Related Articles

HSD3B1 involved in several pathways and played different roles in them. We selected most pathways HSD3B1 participated on our site, such as Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD3B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid hormone biosynthesisUGT1A4;SRD5A2A;UGT1A6B;H2-KE6;CYP3A7;HSD17B12B;CYP3A41B;HSD11B2;UGT5G1
Metabolic pathwaysPOLR2A;TM7SF2;ALG2;CYP1A;HADHAB;C1GALT1C1;POLR2D;GANAB;GBGT1
Ovarian steroidogenesisPLA2G4C;HSD3B6;IGF1R;LHB;HSD17B1;HSD3B4;HSD17B7;INS;STAR
Aldosterone synthesis and secretionPRKCA;CAMK4;CREB3L3;ATF4;AKR1C1;PLCB2;PLCB4;ADCY9;CAMK2B

HSD3B1 has several biochemical functions, for example, 3-beta-hydroxy-delta5-steroid dehydrogenase activity, steroid delta-isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD3B1 itself. We selected most functions HSD3B1 had, and list some proteins which have the same functions with HSD3B1. You can find most of the proteins on our site.

Function Related Protein
3-beta-hydroxy-delta5-steroid dehydrogenase activityHSD3B5;HSD3B4;HSD3B7;HSD3B6;SDR42E1;NSDHL;HSD3B1;HSD3B2
steroid delta-isomerase activityHSD3B1;HSD3B6;HSD3B2;EBP

HSD3B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD3B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD3B1.

Doi, M; Satoh, F; et al. Isoform-Specific Monoclonal Antibodies Against 3 beta-Hydroxysteroid Dehydrogenase/Isomerase Family Provide Markers for Subclassification of Human Primary Aldosteronism. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E257-E262(2014).
Chou, YY; Jeng, YM; et al. HSD3B1 Is a Specific Trophoblast-Associated Marker Not Expressed in a Wide Spectrum of Tumors. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 23:343-347(2013).
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