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HSPBP1

  • Official Full Name

    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

  • Overview

    Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
  • Synonyms

    HSPBP1; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1; hsp70-binding protein 1; FES1; Hsp70 binding protein 1; hsp70 interacting protein; 1500019G21Rik; Heat shock protein 70 binding protein; Heat shock protein 70 interacting protein; Heat shock protein binding protein 1; Heat shock protein-binding protein 1; Heat-shock 70-KD protein-binding protein 1; HPBP1_HUMAN; Hsp 70 binding protein; Hsp 70 interacting protein; Hsp70 binding protein 2; Hsp70 interacting protein 1; Hsp70 interacting protein 2; Hsp70-binding protein 2; Hsp70-interacting protein 1; Hsp70-interacting protein 2; HSPA-binding protein 1; HSPBP; HspBP2; PP1845;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPBP1-26541TH Recombinant Human HSPBP1 E.coli N/A
Human HSPBP1-8061H Recombinant Human HSPBP1 protein, His & GST-tagged E.coli His/GST Asn136~Ser354 (Accession # Q9NZL4)
Human HSPBP1-2408H Recombinant Human HSPBP1, His-tagged E.coli His
Human HSPBP1-29408TH Recombinant Human HSPBP1, T7 -tagged E.coli T7
Human HSPBP1-5126H Recombinant Human HSPBP1 Protein, GST-tagged Wheat Germ GST
Human HSPBP1-5041H Recombinant Human HSPA (Heat Shock 70 KDa) Binding Protein, Cytoplasmic Cochaperone 1, His-tagged Human His
Human HSPBP1-1540H Recombinant Human HSPBP1, T7-tagged E.coli T7
Human HSPBP1-5342HCL Recombinant Human HSPBP1 293 Cell Lysate HEK293 N/A
Human HSPBP1-0567H Recombinant Human HSPBP1 Protein (R84-R359), Tag Free E.coli No tag R84-R359
Human HSPBP1-3972HF Recombinant Full Length Human HSPBP1 Protein, GST-tagged In Vitro Cell Free System GST 359 amino acids
Human HSPBP1-0568H Recombinant Human HSPBP1 Protein (R84-R359), His tagged E.coli His R84-R359
Human HSPBP1-2733H Recombinant Human HSPBP1 Protein (Asn133-Ser351), N-GST tagged E.coli N-GST Asn133-Ser351
Mouse HSPBP1-7922M Recombinant Mouse HSPBP1 Protein Mammalian Cell His
Mouse Hspbp1-8062M Recombinant Mouse Hspbp1 protein, His-tagged E.coli His Ala209~Ser354 (Accession # Q99P31)
Mouse HSPBP1-4368M Recombinant Mouse HSPBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HSPBP1-4368M-B Recombinant Mouse HSPBP1 Protein Pre-coupled Magnetic Beads HEK293
Rat HSPBP1-2956R Recombinant Rat HSPBP1 Protein Mammalian Cell His
Rat Hspbp1-8063R Recombinant Rat Hspbp1 protein, His-tagged E.coli His Ser198~Asp352 (Accession # Q6IMX7)
Rat HSPBP1-2611R-B Recombinant Rat HSPBP1 Protein Pre-coupled Magnetic Beads HEK293
Rat HSPBP1-2611R Recombinant Rat HSPBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HSPBP1-10429Z Recombinant Zebrafish HSPBP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPBP1 Related Articles
  • HSPBP1 Related Research Area

HSPBP1 involved in several pathways and played different roles in them. We selected most pathways HSPBP1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumUBE2D2A;STT3B;TXNDC5;BCAP31;HSPBP1;SEC23B;CAPN2A;HSP70L;BCL2

HSPBP1 has several biochemical functions, for example, adenyl-nucleotide exchange factor activity, enzyme inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPBP1 itself. We selected most functions HSPBP1 had, and list some proteins which have the same functions with HSPBP1. You can find most of the proteins on our site.

Function Related Protein
adenyl-nucleotide exchange factor activityPFN2;SIL1;PFN1;HSPBP1;GRPEL2;GRPEL1
enzyme inhibitor activityPLN;CD46;UGT1A9;SCG5;DGKZ;PDE6G;ANGPTL3;KIAA1967;TXNIP
protein bindingMBD3;HIPK4;ABLIM3;ABCG1;ORAI1;CALM1;PTPN11;SLC25A23;USP2

HSPBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPBP1.

HSPA8; HSPA2; NOTCH2NL; HSPA8

Hromadnikova, I; Dvorakova, L; et al. Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels. MOLECULAR BIOLOGY REPORTS 42:625-637(2015).
Solodkov, AP; Lazuko, SS; et al. Changes in the Profile of NO Synthases Affect Coronary Blood Flow Autoregulation and Myocardial Contractile Activity during Restraint Stress in Rats. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:200-205(2014).
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