hspbp1
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  • Official Full Name
  • HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
  • Background
  • Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
  • Synonyms
  • HSPBP1; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1; hsp70-binding protein 1; FES1; Hsp70 binding protein 1; hsp70 interacting protein; 1500019G21Rik; Heat shock protein 70 binding protein; Heat shock protein 70 interacting protein; Heat shock protein binding protein 1; Heat shock protein-binding protein 1; Heat-shock 70-KD protein-binding protein 1; HPBP1_HUMAN; Hsp 70 binding protein; Hsp 70 interacting protein; Hsp70 binding protein 2; Hsp70 interacting protein 1; Hsp70 interacting protein 2; Hsp70-binding protein 2; Hsp70-interacting protein 1; Hsp70-interacting protein 2; HSPA-binding protein 1; HSPBP; HspBP2; PP1845
Cat.#:HSPBP1-5126HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HSPBP1 Protein, GST-tagged
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Cat.#:HSPBP1-2408HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPBP1, His-tagged
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Cat.#:HSPBP1-1540HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPBP1, T7-tagged
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Cat.#:HSPBP1-26541THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPBP1
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Cat.#:HSPBP1-29408THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPBP1, T7 -tagged
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Cat.#:HSPBP1-5041HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPA (Heat Shock 70 KDa) Binding Protein, Cytoplasmic Cochaperone 1, His-tagged
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Cat.#:HSPBP1-8061HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPBP1 protein, His & GST-tagged
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Cat.#:HSPBP1-7922MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HSPBP1 Protein
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Cat.#:Hspbp1-8062MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hspbp1 protein, His-tagged
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Cat.#:HSPBP1-2956RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HSPBP1 Protein
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Cat.#:Hspbp1-8063RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hspbp1 protein, His-tagged
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Cat.#:HSPBP1-10429ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HSPBP1
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Cat.#:HSPBP1-5342HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HSPBP1 293 Cell Lysate
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Involved Pathway

HSPBP1 involved in several pathways and played different roles in them. We selected most pathways HSPBP1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
CALRL2; PDIA6; ATXN3L; CAPN1A; ATF4B1; HSP90AA1.1; HSPA1A; UBE2D2L; SEC24C; TUSC3

Protein Function

HSPBP1 has several biochemical functions, for example, adenyl-nucleotide exchange factor activity, enzyme inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPBP1 itself. We selected most functions HSPBP1 had, and list some proteins which have the same functions with HSPBP1. You can find most of the proteins on our site.
Function
Related Protein
Function adenyl-nucleotide exchange factor activity
Related Protein GRPEL2; GRPEL1; PFN1; SIL1; PFN2; HSPBP1
Function enzyme inhibitor activity
Related Protein APOV1; CALU; DGKZ; CSN2; ANGPTL4; WDTC1; ATPIF1A; PPP1R12A; ARRB1; SCG5
Function protein binding
Related Protein NPBWR2; ZNF473; LIN28A; NSF; CDCP1; PBRM1; GPS1; CDC25C; ADARB1; KIF7

Interacting Protein

HSPBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPBP1.
HSPA8; HSPA2; NOTCH2NL; HSPA8

HSPBP1 Related Articles

Hromadnikova, I; Dvorakova, L; et al. Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels. MOLECULAR BIOLOGY REPORTS 42:625-637(2015).
Solodkov, AP; Lazuko, SS; et al. Changes in the Profile of NO Synthases Affect Coronary Blood Flow Autoregulation and Myocardial Contractile Activity during Restraint Stress in Rats. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:200-205(2014).