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HTR1A

  • Official Full Name

    5-hydroxytryptamine (serotonin) receptor 1A

  • Overview

    This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the;5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and;pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and;stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic;fevers.
  • Synonyms

    HTR1A; 5-hydroxytryptamine (serotonin) receptor 1A; 5-hydroxytryptamine receptor 1A; 5 HT1A receptor; 5 HT 1A; 5 HT receptor 1A; 5 HT1A; 5 hydroxytryptamine (serotonin) receptor 1A; 5 hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; 5HT 1A; 5HT 1A receptor; 5HT receptor 1A; 5HT1A_HUMAN; ADRB2RL1; ADRBRL1; G 21; G protein coupled receptor; G-21; Gpcr 18; Gpcr18; Guanine nucleotide binding regulatory protein-coupled receptor; Serotonin 1A receptor; Serotonin 5HT1A receptor; Serotonin receptor 1A; 5HT1A; RAT5HT1A;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Equus caballus (Horse)
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Pongo pygmaeus (Bornean orangutan)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Vulpes vulpes (Red fox)
  • Xenopus laevis (African clawed frog)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTR1A-148H Recombinant Human HTR1A Mammalian Cell His
Human HTR1A-25H Recombinant Human HTR1A protein Wheat Germ N/A
Human HTR1A-26H Recombinant Human HTR1A protein, GST-tagged Wheat Germ GST
Human HTR1A-27H Recombinant Human HTR1A protein, GST-tagged Wheat Germ GST
Human HTR1A-2261H Recombinant Human HTR1A Protein, His-tagged E.coli N-His Met1-Gln422
Human HTR1A-1085HFL Recombinant Human HTR1A protein, His&Flag-tagged HEK293 His&Flag 1-422 aa
Human HTR1A-657HF Recombinant Full Length Human HTR1A Protein In Vitro Cell Free System 422 amino acids
Human HTR1A-659HF Recombinant Full Length Human HTR1A Protein, GST-tagged In Vitro Cell Free System GST 422 amino acids
Human HTR1A-3130H Recombinant Human HTR1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HTR1A-3130H-B Recombinant Human HTR1A Protein Pre-coupled Magnetic Beads HEK293
Rat HTR1A-2959R Recombinant Rat HTR1A Protein Mammalian Cell His
Rat HTR1A-2614R-B Recombinant Rat HTR1A Protein Pre-coupled Magnetic Beads HEK293
Rat HTR1A-2614R Recombinant Rat HTR1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canis lupus familiaris (Dog) (Canis familiaris) RFL20727CF Recombinant Full Length Dog 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-423)
Equus caballus (Horse) RFL5482EF Recombinant Full Length Horse 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Gorilla gorilla gorilla (Western lowland gorilla) RFL3027GF Recombinant Full Length Gorilla Gorilla Gorilla 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Homo sapiens (Human) RFL22134HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Mus musculus (Mouse) RFL28633MF Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-421)
Pan troglodytes (Chimpanzee) RFL4180PF Recombinant Full Length Pan Troglodytes 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Pongo pygmaeus (Bornean orangutan) RFL27507PF Recombinant Full Length Pongo Pygmaeus 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Rattus norvegicus (Rat) RFL15325RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Rhesus Macaque HTR1A-2173R Recombinant Rhesus monkey HTR1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque HTR1A-1994R Recombinant Rhesus Macaque HTR1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HTR1A-1994R-B Recombinant Rhesus Macaque HTR1A Protein Pre-coupled Magnetic Beads HEK293
Vulpes vulpes (Red fox) RFL8368VF Recombinant Full Length Vulpes Vulpes 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-423)
Xenopus laevis (African clawed frog) RFL33317XF Recombinant Full Length Xenopus Laevis 5-Hydroxytryptamine Receptor 1A(Htr1A) Protein, His-Tagged E.coli expression system His Full Length (1-408)
Chicken HTR1A-4048C Recombinant Chicken HTR1A Mammalian Cell His
Kit-0995 Total Collagen Assay Kit (Perchlorate-Free) N/A
Kit-1349 HTR1A CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HTR1A Related Articles
  • HTR1A Related Research Area

HTR1A involved in several pathways and played different roles in them. We selected most pathways HTR1A participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayHTR1B;ATP2B4;RAC3;FSHR;NPY;CNGA3;FOS;PLD1;GLI3
Neuroactive ligand-receptor interactionTAAR12H;TAAR14G;GRIK1;GPR50;PTGER4;CHRNA4B;FPR1;TAAR1;ADRB3A
Serotonergic synapseHTR1E;PLCB2;HTR3A;GNG8;MAP2K1;MAPK3;GNG11;GNAI1;PRKCB

HTR1A has several biochemical functions, for example, protein binding, serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR1A itself. We selected most functions HTR1A had, and list some proteins which have the same functions with HTR1A. You can find most of the proteins on our site.

Function Related Protein
protein bindingMBD3;RPS6KA5;RIPPLY3;PSMC6;HLA-DRB3;ICAM5;AKR7A3;PSIP1;RNF43
serotonin receptor activityHTR3C;HTR1AB;HTR4;HTR2CL1;HTR2B;HTR2C;HTR5A;HTR1E;HTR1A

HTR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR1A.

Matthews, PR; Harrison, PJ; et al. A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide. JOURNAL OF AFFECTIVE DISORDERS 137:125-134(2012).
Xu, J; Zhang, GL; et al. Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus. LUPUS 20:678-689(2011).
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