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HUWE1

  • Official Full Name

    HECT, UBA and WWE domain containing 1

  • Overview

    This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.
  • Synonyms

    HUWE1; HECT, UBA and WWE domain containing 1; E3 ubiquitin-protein ligase HUWE1; Ib772; KIAA0312; UREB1; UBA and WWE domain-containing protein 1; ARF binding protein 1; ARF BP1; ARF-binding protein 1; ARF-BP1; E3 ubiquitin protein ligase HUWE1; HECT; HECT UBA and WWE domain containing protein 1; HectH9; Homologous to E6AP carboxyl terminus homologous protein 9; HUWE; HUWE1_HUMAN; KIAA1578; Large structure of UREB1; LASU1; Mcl 1 ubiquitin ligase E3; Mcl-1 ubiquitin ligase E3; MULE; Upstream regulatory element-binding protein 1; URE B1; URE-B1; URE-binding protein 1; UREB 1; OTTHUMP00000023356; OTTHUMP00000023357; BJ-HCC-24 tumor antigen; HECT domain protein LASU1; HECT, UBA; HSPC272;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HUWE1-14016H Recombinant Human HUWE1, GST-tagged E.coli GST C-term-392a.a.
Human HUWE1-136H Recombinant Human HUWE1, GST-tagged E.coli GST
Human HUWE1-14015H Recombinant Human HUWE1, GST-tagged Wheat Germ GST
Rhesus Macaque HUWE1-2179R Recombinant Rhesus monkey HUWE1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HUWE1-2000R Recombinant Rhesus Macaque HUWE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HUWE1-2000R-B Recombinant Rhesus Macaque HUWE1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HUWE1 involved in several pathways and played different roles in them. We selected most pathways HUWE1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HUWE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemCREB1;KIF5B;ACTR1B;DTX3L;TREML2;CD300LD;KIF18A;HUWE1;CD207
Antigen processing: Ubiquitination &ampASB7;GAN;TRIM41;MKRN1;DZIP3;ARIH2;RNF144B;ASB14;RNF138
Proteasome degradationFBXO27;UFL1;UBE2J2;RNF41;RNF4;SPSB4;SPSB2;TRAF7;RNF123
Class I MHC mediated antigen processing &ampSTUB1;SEC23A;RNF123;ASB4;UBE2U;UBE2V2;CTSS;RNF14;TPP2
presentationRNF4;CYBA;DTX3L;RNF14;ASB18;UBE2L6;NPEPPS;RNF41;LRR1
Immune SystemTAX1BP1;FBXO3;UBE2E3;SH3RF1;OSBPL1A;KLRG1;TANK;RIPK3;BTR02
Ubiquitin mediated proteolysisUBE2D1B;RFWD2;UBE3A;HERC2;FANCL;BRCA1;CBLC;SMURF1;SOCS1
Validated targets of C-MYC transcriptional activationMTDH;HUWE1;SERPINI1;NDUFAF2;MYCT1;MINA;CDCA7;LIN28B;IREB2
p53 pathwayKAT8;HUWE1;DYRK2;CSNK1G3;NEDD8;PPP1R13L;TRIM28;FBXO11;E4F1

HUWE1 has several biochemical functions, for example, DNA binding, ligase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HUWE1 itself. We selected most functions HUWE1 had, and list some proteins which have the same functions with HUWE1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingCARF;HOXC12A;ZNF800;HIST1H2AD;UNCX4.1;PPARD;RAD54B;HNF1A;OASL1
ligase activityUBE2KA;NEDD4L;RNF125;TRAIP;NEURL3;MARCH8;MIB2;HECW1B;IRF2BP1
poly(A) RNA bindingRPS17;RBMS1;SRSF3;MRPL13;HIST1H47;DHX34;CCDC124;PPIE;GTPBP1
protein bindingGSTO2;OIT3;TSPAN1;SDCCAG3;NCAPH;PTPN11A;FAM131C;DDX47;RBKS
ubiquitin protein ligase activityITCHA;RNF139;HERC5;MED23;RNF217;CDC42;FBXO6;UBE2V1;FLJ11011L
ubiquitin-protein transferase activityZER1;UBE2R2;IRAK1;RNF31;ZYG11;TRAF2;PDZRN3B;CBL;TRIM2

HUWE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HUWE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HUWE1.

MCL1; CDKN2A; USP7; TP53; HSPB1; vif

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