ibtk
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  • Official Full Name
  • inhibitor of Bruton agammaglobulinemia tyrosine kinase
  • Background
  • Brutons tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains a pleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell devel
  • Synonyms
  • IBTK; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Bruton agammaglobulinemia tyrosine kinase inhibitor , BTKI; inhibitor of Bruton tyrosine kinase; DKFZP564B116; BTK-binding protein; inhibitor of Brutons tyrosine kinase; inhibitor of Brutons ty
Cat.#:IBTK-7967MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IBTK Protein
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Cat.#:IBTK-608CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IBTK Protein, His-tagged
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Cat.#:IBTK-1370HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BTK (Active), His-tagged
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Cat.#:IBTK-5317HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IBTK 293 Cell Lysate
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Involved Pathway

IBTK involved in several pathways and played different roles in them. We selected most pathways IBTK participated on our site, such as BCR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IBTK were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BCR signaling pathway
POU2F2; MAP4K1; MALT1; CSK; PAG1; CSNK2A1; DOK1; NETO2; IBTK

Protein Function

IBTK has several biochemical functions, for example, protein kinase binding, protein tyrosine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IBTK itself. We selected most functions IBTK had, and list some proteins which have the same functions with IBTK. You can find most of the proteins on our site.
Function
Related Protein
Function protein kinase binding
Related Protein PKD1; CDH2; PPP1R12B; TPX2; KIF14; NPR1; CCNYL1; CDK5; MAPKAP1; TP53
Function protein tyrosine kinase inhibitor activity
Related Protein IBTK; FGFR1OP; GNB2L1

Interacting Protein

IBTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IBTK here. Most of them are supplied by our site. Hope this information will be useful for your research of IBTK.
BTK; CD2BP2; RGS2; SNRPN; EIF4A2; PPP1CA; hemC; LAMTOR3; POP7; MSL1; NOP56; SRP72; RPLP1; RPLP0; RPS3; Sars; RFC4; RFC1; RFC3

IBTK Related Articles

Spatuzza, C; Schiavone, M; et al. Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. NUCLEIC ACIDS RESEARCH 36:4402-4416(2008).