igf2bp1
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  • Official Full Name
  • insulin-like growth factor 2 mRNA binding protein 1
  • Background
  • This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IGF2BP1; insulin-like growth factor 2 mRNA binding protein 1; insulin-like growth factor 2 mRNA-binding protein 1; IGF II mRNA binding protein 1; IMP 1; ZBP-1; VICKZ family member 1; zipcode-binding protein 1; IGF2 mRNA-binding protein 1; IGF-II mRNA-bind
Cat.#:IGF2BP1-106HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF2BP1, MYC/DDK-tagged
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Cat.#:IGF2BP1-526HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IGF2BP1 protein, GST-tagged
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Cat.#:IGF2BP1-7698HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2BP1, His-tagged
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Cat.#:IGF2BP1-8066MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IGF2BP1 Protein
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Cat.#:IGF2BP1-2217RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IGF2BP1 Protein, His-tagged
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Cat.#:IGF2BP1-6628CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGF2BP1
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Cat.#:IGF2BP1-4467ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IGF2BP1
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Cat.#:IGF2BP1-5265HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IGF2BP1 293 Cell Lysate
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Involved Pathway

IGF2BP1 involved in several pathways and played different roles in them. We selected most pathways IGF2BP1 participated on our site, such as BDNF signaling pathway, Gene Expression, Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
DOK5; CDKL5; JAK2; FRS2; EGR2; SIRPA; EIF4EBP1; CNR1; GRIP1; DPYSL2
Gene Expression
SNAPC5; GTF3C4; DNMT3B; ZNF493; HNRNPL; MED20; CCNC; POP1; SNAPC3; MED13B
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
IGF2BP1; IGF2BP3; IGF2BP2
MAPK family signaling cascades
CDC42EP2; CDC42EP3; CDC42EP5; MAPK4; CDC42EP1B; SEPT7; IGF2BP1; MAPK6
MAPK6/MAPK4 signaling
CDC42EP1B; CDC42EP2; MAPK4; CDC42EP3; SEPT7; MAPK6; CDC42EP5; IGF2BP1
MicroRNAs in cancer
TP53; WNT3; EFNA3; CDCA5; CCND1; PDGFRB; TRP63; ITGA5; THBS1; CCNG1
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
CDX4; TLE4; ZCCHC12; CYR61; SALL4; T; BCL9; TNIK; HBP1; MYOG
Signal Transduction
NET1; CLPS; RDH14A; ADH8B; DLC1; NMU; LRP10; IQCE; AKAP13; OXGR1A.1

Protein Function

IGF2BP1 has several biochemical functions, for example, mRNA 3-UTR binding, mRNA 5-UTR binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP1 itself. We selected most functions IGF2BP1 had, and list some proteins which have the same functions with IGF2BP1. You can find most of the proteins on our site.
Function
Related Protein
Function mRNA 3-UTR binding
Related Protein IGF2BP2; IGF2BP3; YBX2; AUH; ELAVL1; PPP1R2P9; SECISBP2; ZNF385A; KHSRP; CPEB4
Function mRNA 5-UTR binding
Related Protein DDX3X; MRPS11; IGF2BP1; RPS14; IGF2BP2; LARP1; IGF2BP3
Function mRNA binding
Related Protein CELF1; NUDT16; ITM2B; RBFOX1; FXR2; CSTF3; LUC7L; KIAA0020; IGF2BP1; DHFR
Function nucleotide binding
Related Protein MKNK2A; PCXA; SYNJ2; SPATA5; NCL; CPSF6; POLA1; ATP8A1; DQX1; PABPC5
Function poly(A) RNA binding
Related Protein GLTSCR2; PRPF6; HADHB; RPL35A; RPL21; ZNF622; POP7; HSP90AA1; PPIG; S100A16
Function protein binding
Related Protein ITGA6; JAK2; RNF4; IGFL1; MYL2; TSG101; ZNF550; QRICH1; SNX8; CD24
Function translation regulator activity
Related Protein IGF2BP1; AIRE; RPS9; RPS14; IGF2BP2; YBX2; IGF2BP3

Interacting Protein

IGF2BP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP1.
PRKRA; HLA-B; GSK3B; ARHGDIA; CNBP; Ybx1; PSPH; ILK; IKBKE; SMYD2; LYAR; FTSJ1; PUF60; midostaurin; NS1; pre-let-7a

IGF2BP1 Related Articles

Lederer, M; Bley, N; et al. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. SEMINARS IN CANCER BIOLOGY 29:3-12(2014).