igfbp7
Share
  • Official Full Name
  • insulin-like growth factor binding protein 7
  • Background
  • This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
  • Synonyms
  • IGFBP7; insulin-like growth factor binding protein 7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1; insulin-like growth factor-binding protein 7; IGFBP-rP1; angiomodulin; IGF-binding protein 7; PGI2-stimulating factor; tumor-derived adhesion factor; prostacyclin-stimulating factor;
Cat.#:IGFBP7-529HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP7 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:IGFBP7-208HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP7 Protein
+Inquiry
Cat.#:IGFBP7-2483HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human IGFBP7, His-tagged
+Inquiry
Cat.#:IGFBP7-5054HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor Binding Protein 7
+Inquiry
Cat.#:IGFBP7-5165HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP7, Fc tagged
+Inquiry
Cat.#:IGFBP7-55HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGFBP7
+Inquiry
Cat.#:IGFBP7-6957HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP7, His tagged
+Inquiry
Cat.#:Igfbp7-1786MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Igfbp7 protein, His & T7-tagged
+Inquiry
Cat.#:Igfbp7-5645MTag:His
Source (Host):S. frugiperdaSpecies:Mouse
Product nameRecombinant Mouse Insulin-Like Growth Factor Binding Protein 7, His-tagged
+Inquiry
Cat.#:Igfbp7-971MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Igfbp7 Protein, Fc-tagged
+Inquiry
Cat.#:Igfbp7-1787RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igfbp7 protein, His-tagged
+Inquiry
Cat.#:IGFBP7-12177ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IGFBP7
+Inquiry
Cat.#:IGFBP7-1630HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human IGFBP7, His-tagged
+Inquiry
Cat.#:IGFBP7-1694HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGFBP7 cell lysate
+Inquiry

Involved Pathway

IGFBP7 involved in several pathways and played different roles in them. We selected most pathways IGFBP7 participated on our site, such as Cellular Senescence, Cellular responses to stress, Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular Senescence
TINF2; HIST1H1E; H1F0; HIST1H1B; POT1A; E2F3; KAT5; BMI1A; TERF2; SUZ12A
Cellular responses to stress
HIST1H1B; KIAA1967; TNIK; EGLN3; CBX8; BMI1B; WIPI2; ASF1A; CHMP4C; CDKN2A
Senescence and Autophagy
AMBRA1; UVRAG; RSL1D1; MAP1LC3C; RB1CC1; COL10A1; GABARAPL2; CREG1; IGFBP7; ING2
Senescence-Associated Secretory Phenotype (SASP)
IGFBP7

Protein Function

IGFBP7 has several biochemical functions, for example, insulin-like growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP7 itself. We selected most functions IGFBP7 had, and list some proteins which have the same functions with IGFBP7. You can find most of the proteins on our site.
Function
Related Protein
Function insulin-like growth factor binding
Related Protein HTRA4; NOV; DEFB126; IGF2R; IGFBP7; CYR61; IGFBP1B; IGFBP2B; HTRA3A; WISP1A
Function protein binding
Related Protein GATA1A; NFYC; CA1; KSR1; FBXO11; HPS6; RPL10A; GOLGA7; CSNK1A1; C5orf30

Interacting Protein

IGFBP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP7.
ST14; asnB; q81l39_bacan; dacA; glnK; clcA; hldE; RBBP8; q9r8c5_yerpe

IGFBP7 Related Articles

Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
Chugh, S; Ouzounian, M; et al. Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PROTEOMICS 13:2324-2334(2013).