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IGLL1

Official Full Name

immunoglobulin lambda-like polypeptide 1
Overview

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

IGLL1; immunoglobulin lambda-like polypeptide 1; lambda 5; ig lambda-5; immunoglobulin lambda chain 5; CD179 antigen-like family member B; Igll; Igl-5; Lambda5; BB139905;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Mammalian cells

Tag

C
His
His (Fc)
Avi
His|T7
N/A
N
T7|His

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IGLL1-107H	Recombinant Human IGLL1 protein, T7/His-tagged	E.coli	T7/His		Inquiry
Human	IGLL1-7554H	Recombinant Human IGLL1, His-tagged	E.coli	His	38-213aa	Inquiry
Human	IGLL1-5258HCL	Recombinant Human IGLL1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	IGLL1-1205H	Recombinant Human IGLL1 Protein (Leu29-Ser201), N-His tagged	E.coli	N-His	Leu29-Ser201	Inquiry
Human	IGLL1-4264H	Recombinant Human IGLL1 Protein (Met1-Ser213), C-His tagged	Mammalian cells	C-His	Met1-Ser213	Inquiry
Mouse	IGLL1-8082M	Recombinant Mouse IGLL1 Protein	Mammalian Cell	His		Inquiry
Mouse	Igll1-5647M	Recombinant Mouse Igll1 protein, His & T7-tagged	E.coli	His/T7	Val112~Ala206 (Accession # P20764)	Inquiry
Mouse	IGLL1-4475M	Recombinant Mouse IGLL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	IGLL1-4475M-B	Recombinant Mouse IGLL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	IGLL1-5410C	Recombinant Chicken IGLL1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
IGLL1 Related Articles
IGLL1 Related Research Area

IGLL1 involved in several pathways and played different roles in them. We selected most pathways IGLL1 participated on our site, such as Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGLL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Primary i	CD40LG;CD8A;RFX5;CD4;TNFRSF13B;ORAI1;CD79A;LCK;CD19
nodeficiency	IL7R;AIRE;CD40;UNG;RAG1;AICDA;TNFRSF13B;CD8B1;RFXAP

IGLL1 has several biochemical functions, for example, antigen binding, immunoglobulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGLL1 itself. We selected most functions IGLL1 had, and list some proteins which have the same functions with IGLL1. You can find most of the proteins on our site.

Function	Related Protein
antigen binding	IgG3;Ighg2a;MHC1UKA;TGFB1;IGKV1-5;KIR2DL3;TSPAN4;IGKC;LILRA2
immunoglobulin receptor binding	IGLC2;FGR;Ighg2a;CLEC4D;IgG3;FES;IGLL1;Ighg2b;Ighg

IGLL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGLL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGLL1.

ltp_ebvg; q9wmx2-pro_0000037551; IGHG1; MME; CD9

Luo, T; Kuriakose, JA; et al. Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization. INFECTION AND IMMUNITY 79:4382-4391(2011).

Wang, Y; Kanegane, H; et al. Novel Ig alpha (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia. AMERICAN JOURNAL OF MEDICAL GENETICS 108:333-336(2002).

B Cell CD Antigen