ihh
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  • Official Full Name
  • indian hedgehog
  • Background
  • This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]
  • Synonyms
  • IHH; indian hedgehog; BDA1; HHG2; indian hedgehog protein; HHG-2; Indian hedgehog homolog;
Cat.#:IHH-1673HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IHH protein, His & T7-tagged
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Cat.#:IHH-656HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IHH protein
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Cat.#:IHH-7884HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IHH protein, His-tagged
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Cat.#:IHH-6516CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IHH
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Cat.#:Ihh-1892MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Indian Hedgehog
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Involved Pathway

Ihh involved in several pathways and played different roles in them. We selected most pathways Ihh participated on our site, such as Hedgehog signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ihh were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hedgehog signaling pathway
WNT4; PRKACAA; WNT5B; LRP2; PTCH2; PRKACAB; CSNK1G1; WNT7A; DYRK1A; DYRK1AA

Protein Function

Ihh has several biochemical functions, for example, calcium ion binding, patched binding, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ihh itself. We selected most functions Ihh had, and list some proteins which have the same functions with Ihh. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein VIL1; CANX; MACF1; PCDH18B; SULF1; EFCAB5; PCDHB14; HMCN1; CD97; S100A13
Function patched binding
Related Protein DHH; BBS1; CAV1; PTCH1; Shh; IHH; SMO; CCNB1; SETD6
Function peptidase activity
Related Protein LGMN; Shh; IWS1; PSD; ZMPSTE24; SHHA; ST14A; PROCA; HM13; PSMB9B

Interacting Protein

Ihh has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ihh here. Most of them are supplied by our site. Hope this information will be useful for your research of Ihh.
RHOD

Ihh Related Articles

Kebenko, M; Drenckhan, A; et al. ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts. CELLULAR SIGNALLING 27:373-381(2015).
Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).