irf6
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  • Official Full Name
  • interferon regulatory factor 6
  • Background
  • This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
  • Synonyms
  • IRF6; interferon regulatory factor 6; LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1;
Cat.#:IRF6-5035HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF6 Protein, GST-tagged
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Cat.#:IRF6-2017HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF6 protein, His & T7-tagged
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Cat.#:IRF6-28727THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IRF6
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Cat.#:Irf6-2018MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irf6 protein, His & T7-tagged
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Cat.#:IRF6-8304MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRF6 Protein
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Cat.#:IRF6-2299RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF6 Protein, His-tagged
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Cat.#:IRF6-10876ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRF6
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Cat.#:IRF6-5161HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF6 293 Cell Lysate
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Involved Pathway

IRF6 involved in several pathways and played different roles in them. We selected most pathways IRF6 participated on our site, such as Apoptosis, Cytokine Signaling in Immune system, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
TNFRSF10D; BIDA; PPP3R2; IRF4A; STK24A; NFKBIA; BOKA; Casp3; CSF2RB; CASP9
Cytokine Signaling in Immune system
TRIM22; TRIM26; EIF4A2; EDAR; IFIT10; FGF18B; FRS3; UBE2V1; EGR1; RASGEF1A
Immune System
CTLA4; TREM1; NA; TRIM22; TRIM62; SEC23A; TNIP2; TRIM2; CTSK; TREML4
Interferon Signaling
IFIT14; TRIM22; EIF4G2; GBP6; SAMHD1; XAF1; TRIM68; IRF2; TRIM38; GBP4
Interferon alpha/beta signaling
IRF6; IRF9; IFIT2; ISG20; USP18; IRF2; IFITM3; XAF1; SAMHD1; IFITM2
Interferon gamma signaling
FCGR1B; IRF6; TRIM17; TRIM3; TRIM45; TRIM62; TRIM31; OASL; TRIM38; IFI30

Protein Function

IRF6 has several biochemical functions, for example, DNA binding, protein binding, regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF6 itself. We selected most functions IRF6 had, and list some proteins which have the same functions with IRF6. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFP488; ZNF711; ZNF433; IRF1; MCMDC2; ZEB1B; ZNF319; IRF7; HIST1H47; ARX
Function protein binding
Related Protein CRYAB; TMPRSS2; MAP3K11; MED25; ABCD3; SPATA22; SELL; MAGI1; MYH11; TBC1D19
Function regulatory region DNA binding
Related Protein IRF1A; IRF8; IRF1B; IRF2A; NFKB1; IRF3; HMGA2; IRF5; IRF6; IRF4A
Function transcription factor activity, sequence-specific DNA binding
Related Protein DMRT2; FOXL2; POU4F3; LMX1B; ATF7; FOXP3A; KCNA3; PURBA; YEATS4; FOXP4

Interacting Protein

IRF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF6.
IRF8; IRF5; BNC2

IRF6 Related Articles

Koelsch, KA; Webb, R; et al. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. JOURNAL OF AUTOIMMUNITY 41:168-174(2013).

IRF6 Related Gene Family

Cytokines