IRS2
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Official Full Name
insulin receptor substrate 2 -
Overview
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin,;insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine;kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase;upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. -
Synonyms
IRS2;insulin receptor substrate 2;IRS-2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IRS2-1051H | Recombinant Human IRS2 protein, His & T7-tagged | E.coli | Human | His&T7 | Ser985~Ala1255 |
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| IRS2-8314M | Recombinant Mouse IRS2 Protein | Mammalian Cells | Mouse | His |
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| IRS2-3213H | Recombinant Human IRS2 Protein (Ser985-Ala1255), N-His tagged | E.coli | Human | His | Ser985-Ala1255 |
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| IRS2-4611M | Recombinant Mouse IRS2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| IRS2-4611M-B | Recombinant Mouse IRS2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| IRS2-5029H | Recombinant Human IRS2 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
IRS2 involved in several pathways and played different roles in them. We selected most pathways IRS2 participated on our site, such as cGMP-PKG signaling pathway,FoxO signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | NDUFB1,GSK3B,NDUFC2,PIK3CB,ADIPOR1,UQCR11,NDUFS5,PIK3R5,NDUFB4,PRKAG2 |
| Insulin resistance | AKT2,PRKAB1B,PYGL,NFKBIA,SLC27A5,SLC27A1A,GYS2,OGT.1,GFPT2,CREB3L1 |
| Insulin signaling pathway | HK1,TSC1A,PPP1R3A,PHKA2,MKNK2A,IKBKB,SOCS3,HK3,SHC1,MAPK10 |
| Type II diabetes mellitus | INS2,MTOR,PIK3R1,PRKCD,MAPK3,PKM2,PIK3CG,PRKCZ,SLC2A4,MAPK10 |
| Regulation of lipolysis in adipocytes | PIK3CB,PIK3R1,PIK3R2,TSHB,INS1,INS,IRS1,LOC100328615,GNAI1,INSR |
| AMPK signaling pathway | PFKL,CCNA1,CPT1C,RPTOR,PFKFB2,PFKP,RAB14,SIRT1,PPP2R1A,PRKAG2 |
| FoxO signaling pathway | GADD45B,G6PC,PIK3R3,KRAS,MAPK3,INS1,BNIP4,HRAS,MDM2,PRKAA1 |
| Adipocytokine signaling pathway | RELA,ADIPOQB,ADIPOR2,RXRBA,PRKAB1,AKT3A,RXRGA,LEPA,MAPK10,PTPN11A |
| MicroRNAs in cancer | PIK3R2,TP63,VEGFA,ZEB2,MARCKS,MDM2,Casp3,DNMT3A,CYP24A1,CCND2 |
Protein Function
IRS2 has several biochemical functions, for example, 14-3-3 protein binding,insulin receptor binding,phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS2 itself. We selected most functions IRS2 had, and list some proteins which have the same functions with IRS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | RAPGEF3,PPP3R1,GABRR2,ARHGEF4,STAMBP,PLXND1,HIST1H4D,YWHAB,IPCEF1,TADA3 |
| insulin receptor binding | PTPN11,SHC1,FRS2,DOK2,SNX1,SNX4,IGF1R,DOK6,IGF2,PHIP |
| phosphatidylinositol 3-kinase binding | CALM2,IGF1RB,INSRR,INSR,IGF1R,DAB1,PDGFRB,IRS1,FLT3,TYRO3 |
| protein phosphatase binding | GNB2L1,PIK3R2,ANAPC7,RPA2,FGF19,RPA3,CTNNB1,PPP1R3G,JAK1,VCAN |
| protein kinase binding | AP1B1,MAML1,EEF1A1,LSM2,CACNB4,PIWIL1,CCNT2B,ATP1A1,KCNH1,PRC1 |
| protein binding | C1QTNF3,CSF2,OLFM2,LGALS14,CRP,DAB1,RING1,VPS37B,HSPBP1,SYT11 |
| 14-3-3 protein binding | SRPK2,YWHAQ,PPP1R12A,ZFP36,ARRB2,DDIT4,TSC2,AKT1,AANAT,PRKCE |
Interacting Protein
IRS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS2.
Ncl;Znf592;Lonp1;TP53BP2;Insr;Phip;Sirt1;SIRT1;Lyn
Resources
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References
- Hancer, NJ; Qiu, W; et al. Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:12467-12484(2014).
- Zerzaihi, O; Chriett, S; et al. Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 92:61-67(2014).
