KCNIP2
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Official Full Name
Kv channel interacting protein 2
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Overview
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. -
Synonyms
KCNIP2; Kv channel interacting protein 2; Kv channel-interacting protein 2; KCHIP2; potassium channel-interacting protein 2; A-type potassium channel modulatory protein 2; cardiac voltage-gated potassium channel modulatory subunit; MGC17241; DKFZp566L1246;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
KCNIP2 involved in several pathways and played different roles in them. We selected most pathways KCNIP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNIP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
KCNIP2 has several biochemical functions, for example, contributes_to A-type (transient outward) potassium channel activity, A-type (transient outward) potassium channel activity, ER retention sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNIP2 itself. We selected most functions KCNIP2 had, and list some proteins which have the same functions with KCNIP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to A-type (transient outward) potassium channel activity | KCND3;KCNIP2 |
| A-type (transient outward) potassium channel activity | KCNIP2;KCND2 |
| ER retention sequence binding | KDELR2B;KDELR2A;KIAA1199;KCNIP2;KDELR3 |
| calcium ion binding | HMCN1;PCDH2AA15;KCNIP3B;DCHS1;EFHA1;PCDH1G1;CDH15;SYT5A;F2 |
| identical protein binding | SCUBE1;CRYAB;KCTD17;TP63;ALDOA;BCL2;BCL2L1;LDHA;UAP1 |
| ion channel binding | KCNQ3;RYR2;S100A10;ACTN2;DLG1;CALM2;KCNE1L;KCNB1;PACS1 |
| potassium channel regulator activity | KCNMB2;PIAS3;SGK1;KCNV1;KCNIP2;KCNAB1;SGK3;LRRC26;KCNAB3 |
| protein N-terminus binding | PPP1CC;KCNIP2;ZWINT;STX1A;GTF2H3;PHB2;VPS25;SLC6A3;TGFB1 |
| protein binding | TDRKH;DNAJC15;HPGDS;WBP2;CD82;PPP4R2;KRT2;KLK6;CD164 |
KCNIP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNIP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNIP2.
KCND2; KCNIP4
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