kir2dl1
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  • Official Full Name
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
  • Background
  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
  • Synonyms
  • KIR2DL1; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; killer cell immunoglobulin-like receptor 2DL1; 47.11; CD158A; cl 42; nkat1; p58.1; NKAT-1; killer Ig receptor; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; killer inhibitory receptor 2-2-1; CD158 antigen-like family member A; natural killer-associated transcript 1; p58 NK cell inhibitory receptor NKR-K6; p58.1 MHC class-I-specific NK receptor; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11; NKAT; KIR221; KIR-K64
Cat.#:KIR2DL1-145HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIR2DL1
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Cat.#:KIR2DL1-28651THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIR2DL1
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Cat.#:KIR2DL1-495HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL1 Protein, His-tagged
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Cat.#:KIR2DL1-6967HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL1, Fc tagged
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Cat.#:KIR2DL1-7063HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KIR2DL1 protein, His & GST-tagged
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Cat.#:KIR2DL1-1657HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL1 cell lysate
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Cat.#:KIR2DL1-1701HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human KIR2DL1 cell lysate
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Involved Pathway

KIR2DL1 involved in several pathways and played different roles in them. We selected most pathways KIR2DL1 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
HSP90AA1; KIR3DL2; HLA-DRA; KIR2DS5; HSPA5; CD8B1; KLRC2; KIR2DS4; HSPA8; HLA-DQA1
Natural killer cell mediated cytotoxicity
HCST; Ifna11; CD48; ITGAL; RAC3; TNF; PTK2B; PPP3R1; TNFRSF10C; KIR3DL1
Graft-versus-host disease
CD28; HLA-A; TNF; HLA-DOB; KLRD1; HLA-F; HLA-E; HLA-DPB1; KLRC1; CD86

Protein Function

KIR2DL1 has several biochemical functions, for example, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DL1 itself. We selected most functions KIR2DL1 had, and list some proteins which have the same functions with KIR2DL1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein CITED1; FHL2; SIPA1L2; KRT79; TBC1D20; ZNF398; NUP155; UBXN6; NFKBIA; MLF1IP
Function receptor activity
Related Protein GFRA4A; NPR2; SLC1A5; CD244; IL10RB; LYVE1; XPR1; CSF2RA; TREM2; NOTCH2

Interacting Protein

KIR2DL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DL1.
PIK3R1; PTPN11; PTPN6

KIR2DL1 Related Articles

He, YM; Tao, SD; et al. Allelic polymorphism, mRNA and antigen expression of KIR2DL1 in the Chinese Han population. HUMAN IMMUNOLOGY 75:245-249(2014).
Czaja, K; Borer, AS; et al. A comprehensive analysis of the binding of anti-MR antibodies to activating KIRs. GENES AND IMMUNITY 15:33-37(2014).