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KIR2DL1

  • Official Full Name

    killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1

  • Overview

    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
  • Synonyms

    KIR2DL1; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; killer cell immunoglobulin-like receptor 2DL1; 47.11; CD158A; cl 42; nkat1; p58.1; NKAT-1; killer Ig receptor; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; killer inhibitory receptor 2-2-1; CD158 antigen-like family member A; natural killer-associated transcript 1; p58 NK cell inhibitory receptor NKR-K6; p58.1 MHC class-I-specific NK receptor; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11; NKAT; KIR221; KIR-K64;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Homo sapiens (Human)
  • Human
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • His|GST
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KIR2DL1-495H Recombinant Human KIR2DL1 Protein, His-tagged HEK293 His
Human KIR2DL1-6967H Recombinant Human KIR2DL1, Fc tagged Human Cell Fc
Human KIR2DL1-28651TH Recombinant Human KIR2DL1 E.coli N/A
Human KIR2DL1-145H Recombinant Human KIR2DL1 E.coli N/A
Human KIR2DL1-7063H Recombinant Human KIR2DL1 protein, His & GST-tagged E.coli His/GST His22~Pro348
Human KIR2DL1-1701HCL Recombinant Human KIR2DL1 cell lysate Human Cell N/A
Human KIR2DL1-1657HCL Recombinant Human KIR2DL1 cell lysate Human Cell N/A
Human KIR2DL1-496H Recombinant Human KIR2DL1 protein, His-Avi-tagged HEK293 His-Avi His22-Arg242
Human KIR2DL1-626HB Recombinant Human KIR2DL1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi His22-Arg242
Human KIR2DL1-080H Recombinant Human KIR2DL1 Protein, C-His-tagged E.coli C-His
Human KIR2DL1-3336H Recombinant Human KIR2DL1 protein, His-tagged E.coli His His22~His245
Human KIR2DL1-1906H Active Recombinant Human KIR2DL1 protein, Fc-tagged HEK293 Fc His 22 - Arg 242
Human KIR2DL1-4335H Recombinant Human KIR2DL1 Protein (Met1-His245), C-His tagged Mammalian cells C-His Met1-His245
Homo sapiens (Human) RFL27193HF Recombinant Full Length Human Killer Cell Immunoglobulin-Like Receptor 2Dl1(Kir2Dl1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-348)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KIR2DL1 Related Articles
  • KIR2DL1 Related Research Area

KIR2DL1 involved in several pathways and played different roles in them. We selected most pathways KIR2DL1 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antigen processing and presentationTAP2;HLA-F;RFXANK;TAP1;CTSS;HSPA5;HLA-DRB5;HLA-DPA1;CTSB
Natural killer cell mediated cytotoxicityKLRD1;TNFRSF10C;KLRC1;KLRA8;TNF;IFNA7;KIR2DL1;VAV1;RAET1L
Graft-versus-host diseaseHLA-DMA;PRF1;KLRD1;IL1A;Fasl;HLA-DMB;KIR3DL1;HLA-DQB1;CD28

KIR2DL1 has several biochemical functions, for example, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DL1 itself. We selected most functions KIR2DL1 had, and list some proteins which have the same functions with KIR2DL1. You can find most of the proteins on our site.

Function Related Protein
protein bindingPTGDR;TSPAN4;TACC3;RNF41;ALKBH8;NSUN4;SUPT6H;POP7;KL
receptor activityGRIA3A;ICAM1;KLRB1F;ADIPOR1A;CADM2;SIGLEC7;CLEC4E;NLGN2;XPR1

KIR2DL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DL1.

PIK3R1; PTPN11; PTPN6

He, YM; Tao, SD; et al. Allelic polymorphism, mRNA and antigen expression of KIR2DL1 in the Chinese Han population. HUMAN IMMUNOLOGY 75:245-249(2014).
Czaja, K; Borer, AS; et al. A comprehensive analysis of the binding of anti-MR antibodies to activating KIRs. GENES AND IMMUNITY 15:33-37(2014).
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