KLC1

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KLC1

Official Full Name kinesin light chain 1
Background Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various;cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains;bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy;chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in;binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as;adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the;kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms;with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or;biological validity of most of these variants have not been determined.
Synonyms KLC1; kinesin light chain 1; Kinesin 2 60/70kDa; Kinesin2; KLC 1; KLC; KLC1_HUMAN; KNS 2; KNS 2A; KNS2; KNS2A; Medulloblastoma antigen MU MB 2.50; MGC15245; kinesin 2
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Bence Jones Urine
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KLC1-27879TH Recombinant Human KLC1, His-tagged E.coli His
    Human KLC1-4935HCL Recombinant Human KLC1 293 Cell Lysate HEK293 N/A
    Human KLC1-5355H Native Human Kinesin Light Chain 1 Human Bence Jones Urine N/A
    Human KLC1-5849H Recombinant Human KLC1 protein, GST-tagged E.coli GST
    Human KLC1-7881H Recombinant Human KLC1 protein, His & T7-tagged E.coli His/T7
    Rat KLC1-3267R Recombinant Rat KLC1 Protein Mammalian Cell His

    KLC1 involved in several pathways and played different roles in them. We selected most pathways KLC1 participated on our site, such as Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Salmonella infection TLR4; CDC42L2; PFN2L; CXCL1; KLC4; PFN2; RELA; NOS2A; CCL4L2; FLNA

    KLC1 has several biochemical functions, for example, microtubule motor activity, motor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLC1 itself. We selected most functions KLC1 had, and list some proteins which have the same functions with KLC1. You can find most of the proteins on our site.

    Function Related Protein
    microtubule motor activity KIF15; KLC1A; KIF3CB; KIFC1; DNAH11; KLC1B; DNAIC2; DNAHC8; DYNC1I1; KIF3B
    motor activity DCTN2; DYNLL2; MYHZ2; MYO1C; MYO5C; MYL6; MYO1EB; KIF2A; MYH1; DYNC2LI1
    protein binding SCN11A; ACTL8; MZT1; CYB561; CASP10; LCK; KIF14; MIER1; BCL2L14; DENND2D

    KLC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLC1.

    YWHAB; BNIP2; KRT31; CCDC114; SFN; YWHAG; YWHAZ; RUSC1; HSPB1; MAPK6; LRSAM1; d-mannose; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate

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